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Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

This study evaluated the performance of a YOLOv8-based segmentation model for detecting and segmenting wrinkles in facial images.

Computer Vision and Pattern Recognition · Computer Science 2025-05-19 Rana Poureskandar , Shiva Razzagzadeh

For a long time, bone marrow cell morphology examination has been an essential tool for diagnosing blood diseases. However, it is still mainly dependent on the subjective diagnosis of experienced doctors, and there is no objective…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Dehao Huang , Jintao Cheng , Rui Fan , Zhihao Su , Qiongxiong Ma , Jie Li

Morphology based analysis of cell types has been an area of great interest to the neuroscience community for several decades. Recently, high resolution electron microscopy (EM) datasets of the mouse brain have opened up opportunities for…

In voltage imaging, where the membrane potentials of individual neurons are recorded at from hundreds to thousand frames per second using fluorescence microscopy, data processing presents a challenge. Even a fraction of a minute of…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Yosuke Bando , Ramdas Pillai , Atsushi Kajita , Farhan Abdul Hakeem , Yves Quemener , Hua-an Tseng , Kiryl D. Piatkevich , Changyang Linghu , Xue Han , Edward S. Boyden

The automated analysis of microscopy images is a challenge in the context of single-cell tracking and quantification. This work has as goals the study of the performance of deep learning for segmenting microscopy images and the improvement…

Quantitative Methods · Quantitative Biology 2022-10-05 André O. Françani

Cell instance segmentation in fluorescence microscopy images is becoming essential for cancer dynamics and prognosis. Data extracted from cancer dynamics allows to understand and accurately model different metabolic processes such as…

The shape and connectivity of a neuron determine its function. Modern imaging methods have proven successful at extracting such information. However, in order to analyze this type of data, neuronal morphology needs to be encoded in a…

Neurons and Cognition · Quantitative Biology 2019-03-07 Tamal Batabyal , Barry Condron , Scott T. Acton

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

Deep learning has revolutionized medical and biological imaging, particularly in segmentation tasks. However, segmenting biological cells remains challenging due to the high variability and complexity of cell shapes. Addressing this…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Tianhao Zhang , Heather J. McCourty , Berardo M. Sanchez-Tafolla , Anton Nikolaev , Lyudmila S. Mihaylova

Recent studies have demonstrated the superiority of deep learning in medical image analysis, especially in cell instance segmentation, a fundamental step for many biological studies. However, the excellent performance of the neural networks…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Huaqian Wu , Nicolas Souedet , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

In this paper, we present a novel use of an anisotropic diffusion model for automatic detection of neurons in histological sections of the adult human brain cortex. We use a partial differential equation model to process high resolution…

Computer Vision and Pattern Recognition · Computer Science 2018-12-20 Andrija Štajduhar , Domagoj Džaja , Miloš Judaš , Sven Lončarić

Fluorescence microscopy allows for a detailed inspection of cells, cellular networks, and anatomical landmarks by staining with a variety of carefully-selected markers visualized as color channels. Quantitative characterization of…

Computer Vision and Pattern Recognition · Computer Science 2021-08-26 Alvaro Gomariz , Tiziano Portenier , Patrick M. Helbling , Stephan Isringhausen , Ute Suessbier , César Nombela-Arrieta , Orcun Goksel

The current neuron reconstruction pipeline for electron microscopy (EM) data usually includes automatic image segmentation followed by extensive human expert proofreading. In this work, we aim to reduce human workload by predicting…

Computer Vision and Pattern Recognition · Computer Science 2024-01-09 Qihua Chen , Xuejin Chen , Chenxuan Wang , Yixiong Liu , Zhiwei Xiong , Feng Wu

Neurofibromatosis Type 1 is a genetic disorder characterized by the development of neurofibromas (NFs), which exhibit significant variability in size, morphology, and anatomical location. Accurate and automated segmentation of these tumors…

Image and Video Processing · Electrical Eng. & Systems 2025-11-18 Georgii Kolokolnikov , Marie-Lena Schmalhofer , Lennart Well , Said Farschtschi , Victor-Felix Mautner , Inka Ristow , Rene Werner

Instance segmentation is an important image processing operation for agricultural automation, providing precise delineation of individual objects within images and enabling tasks such as selective harvesting and precision pruning. This…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Ranjan Sapkota , Dawood Ahmed , Manoj Karkee

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

The increasing prevalence of thyroid cancer globally has led to the development of various computer-aided detection methods. Accurate segmentation of thyroid nodules is a critical first step in the development of AI-assisted clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Mahmoud El Hussieni

Neuroanatomical segmentation in magnetic resonance imaging (MRI) of the brain is a prerequisite for volume, thickness and shape measurements. This work introduces a new highly accurate and versatile method based on 3D convolutional neural…

Quantitative Methods · Quantitative Biology 2019-02-07 Philip Novosad , Vladimir Fonov , D. Louis Collins

Recent technological advances in cutting-edge ultrasensitive fluorescence microscopy have allowed single-molecule imaging experiments in living cells across all three domains of life to become commonplace. Single-molecule live-cell data is…

Biomolecules · Quantitative Biology 2015-04-15 Mark Leake