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Deformable medical image registration is an essential task in computer-assisted interventions. This problem is particularly relevant to oncological treatments, where precise image alignment is necessary for tracking tumor growth, assessing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Stefano Fogarollo , Gregor Laimer , Reto Bale , Matthias Harders

Deformable registration is one of the most challenging task in the field of medical image analysis, especially for the alignment between different sequences and modalities. In this paper, a non-rigid registration method is proposed for 3D…

Computer Vision and Pattern Recognition · Computer Science 2020-02-27 Xiaoyue Zhang , Weijian Jian , Yu Chen , Shihting Yang

The importance of regularization has been well established in image reconstruction -- which is the computational inversion of imaging forward model -- with applications including deconvolution for microscopy, tomographic reconstruction,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Sanjay Viswanath , Manu Ghulyani , Muthuvel Arigovindan

Multi-contrast image registration is a challenging task due to the complex intensity relationships between different imaging contrasts. Conventional image registration methods are typically based on iterative optimizations for each input…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Yinsong Wang , Siyi Du , Shaoming Zheng , Xinzhe Luo , Chen Qin

Deformable image registration is a fundamental problem in the field of medical image analysis. During the last years, we have witnessed the advent of deep learning-based image registration methods which achieve state-of-the-art performance,…

Image and Video Processing · Electrical Eng. & Systems 2020-02-03 Lucas Mansilla , Diego H. Milone , Enzo Ferrante

Deep learning has achieved significant advancements in medical image segmentation, but existing models still face challenges in accurately segmenting lesion regions. The main reason is that some lesion regions in medical images have unclear…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Lexin Fang , Yunyang Xu , Xiang Ma , Xuemei Li , Caiming Zhang

Along with the successful deployment of deep neural networks in several application domains, the need to unravel the black-box nature of these networks has seen a significant increase recently. Several methods have been introduced to…

Machine Learning · Computer Science 2023-07-06 Adam Ivankay , Mattia Rigotti , Pascal Frossard

Conventional deformable registration methods aim at solving an optimization model carefully designed on image pairs and their computational costs are exceptionally high. In contrast, recent deep learning based approaches can provide fast…

Computer Vision and Pattern Recognition · Computer Science 2021-10-01 Risheng Liu , Zi Li , Xin Fan , Chenying Zhao , Hao Huang , Zhongxuan Luo

Nonlinear image registration continues to be a fundamentally important tool in medical image analysis. Diagnostic tasks, image-guided surgery and radiotherapy as well as motion analysis all rely heavily on accurate intra-patient alignment.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-26 Mattias P. Heinrich

Medical image segmentation has been widely recognized as a pivot procedure for clinical diagnosis, analysis, and treatment planning. However, the laborious and expensive annotation process lags down the speed of further advances.…

Computer Vision and Pattern Recognition · Computer Science 2022-05-02 Zhuowei Li , Zihao Liu , Zhiqiang Hu , Qing Xia , Ruiqin Xiong , Shaoting Zhang , Dimitris Metaxas , Tingting Jiang

We present deformable unsupervised medical image registration using a randomly-initialized deep convolutional neural network (CNN) as regularization prior. Conventional registration methods predict a transformation by minimizing…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Large deformations of organs, caused by diverse shapes and nonlinear shape changes, pose a significant challenge for medical image registration. Traditional registration methods need to iteratively optimize an objective function via a…

Image and Video Processing · Electrical Eng. & Systems 2022-05-03 Ziwei Luo , Jing Hu , Xin Wang , Shu Hu , Bin Kong , Youbing Yin , Qi Song , Xi Wu , Siwei Lyu

In this paper, we present a novel unsupervised domain adaptation (UDA) method, named Domain Adaptive Relational Reasoning (DARR), to generalize 3D multi-organ segmentation models to medical data collected from different scanners and/or…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Shuhao Fu , Yongyi Lu , Yan Wang , Yuyin Zhou , Wei Shen , Elliot Fishman , Alan Yuille

In recent years, conditional image synthesis has attracted growing attention due to its controllability in the image generation process. Although recent works have achieved realistic results, most of them have difficulty handling…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Yueming Lyu , Peibin Chen , Jingna Sun , Bo Peng , Xu Wang , Jing Dong

Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans essential. Conventional DIR methods are often too slow for…

Image registration aims to establish spatial correspondence across pairs, or groups of images, and is a cornerstone of medical image computing and computer-assisted-interventions. Currently, most deep learning-based registration methods…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Xiang Chen , Nishant Ravikumar , Yan Xia , Alejandro F Frangi

Image registration is an ill-posed inverse problem which often requires regularisation on the solution space. In contrast to most of the current approaches which impose explicit regularisation terms such as smoothness, in this paper we…

Image and Video Processing · Electrical Eng. & Systems 2020-07-09 Chen Qin , Shuo Wang , Chen Chen , Huaqi Qiu , Wenjia Bai , Daniel Rueckert

Medical image registration is a challenging task involving the estimation of spatial transformations to establish anatomical correspondence between pairs or groups of images. Recently, deep learning-based image registration methods have…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Xiang Chen , Yan Xia , Nishant Ravikumar , Alejandro F Frangi

Regularization is essential in deformable image registration (DIR) to ensure that the estimated Deformation Vector Field (DVF) remains smooth, physically plausible, and anatomically consistent. However, fine-tuning regularization parameters…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Sidaty El Hadramy , Oumeymah Cherkaoui , Philippe C. Cattin

Reinforcement learning improves the reasoning ability of large language models but remains costly and sample-inefficient, as many rollouts provide weak learning signals. Difficulty-aware data selection methods attempt to address this by…

Machine Learning · Computer Science 2026-05-12 Yang Zhou , Can Jin , Zihan Dong , Zhepeng Wang , Yanting Yang , Shiyu Zhao , Lei Li , Runxue Bao , Yaochen Xie , Dimitris N. Metaxas