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We introduce and analyze a within-host dynamical model of the coevolution between rapidly mutating pathogens and the adaptive immune response. Pathogen mutation and a homeostatic constraint on lymphocytes both play a role in allowing the…

Populations and Evolution · Quantitative Biology 2014-08-06 Kimberly J. Schlesinger , Sean P. Stromberg , Jean M. Carlson

Interaction patterns among individuals play vital roles in spreading infectious diseases. Understanding these patterns and integrating their impact in modeling diffusion dynamics of infectious diseases are important for epidemiological…

Social and Information Networks · Computer Science 2018-04-02 Md Shahzamal , Raja Jurdak , Bernard Mans , Ahmad El Shoghri , Frank De Hoog

Background: Human behavior shapes infectious disease dynamics, yet its integration into transmission models remains fragmented. Recent epidemics, particularly COVID-19, highlight the need for models capturing adaptation to perceived risk,…

Populations and Evolution · Quantitative Biology 2026-02-19 Youngji Jo , Sileshi Sintayehu Sharbayta , Bruno Buonomo

To what extent are effectiveness estimates of nonpharmaceutical interventions (NPIs) against COVID-19 influenced by the assumptions our models make? To answer this question, we investigate 2 state-of-the-art NPI effectiveness models and…

In recent years, there has been growing interest in studying games on multiplex networks that account for interactions across linked social contexts. However, little is known about how potential cross-context interference, or spillover, of…

Physics and Society · Physics 2017-10-11 Tommy Khoo , Feng Fu , Scott Pauls

We study the spreading of cooperative infections in an empirical temporal network of contacts between people, including health care workers and patients, in a hospital. The system exhibits a phase transition leading to one or several…

Physics and Society · Physics 2018-02-08 Jorge P. Rodríguez , Fakhteh Ghanbarnejad , Víctor M. Eguíluz

Between pandemics, the influenza virus exhibits periods of incremental evolution via a process known as antigenic drift. This process gives rise to a sequence of strains of the pathogen that are continuously replaced by newer strains,…

Populations and Evolution · Quantitative Biology 2020-08-18 Adam Griffin , Simon E. F. Spencer , Gareth O. Roberts

A key scientific challenge during the outbreak of novel infectious diseases is to predict how the course of the epidemic changes under different countermeasures that limit interaction in the population. Most epidemiological models do not…

Physics and Society · Physics 2023-01-25 Mansi Sood , Anirudh Sridhar , Rashad Eletreby , Chai Wah Wu , Simon A. Levin , H. Vincent Poor , Osman Yagan

We propose a network behavioral-feedback Susceptible-Infected-Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model…

Dynamical Systems · Mathematics 2025-07-08 Martina Alutto , Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani

By incorporating segregated spatial domain and individual-based linkage into the SIS (susceptible-infected-susceptible) model, we investigate the coupled effects of random walk and intragroup interaction on contagion. Compared with the…

Physics and Society · Physics 2015-05-05 Li-Xin Zhong , Wen-Juan Xu , Rong-Da Chen , Tian Qiu , Chen-Yang Zhong

The impact that information diffusion has on epidemic spreading has recently attracted much attention. As a disease begins to spread in the population, information about the disease is transmitted to others, which in turn has an effect on…

Physics and Society · Physics 2015-06-15 Xiu-Xiu Zhan , Chuang Liu , Ge Zhou , Zi-Ke Zhang , Gui-Quan Sun , Jonathan J. H. Zhu

Human behavior plays a critical role in shaping epidemic trajectories. During health crises, people respond in diverse ways in terms of self-protection and adherence to recommended measures, largely reflecting differences in how individuals…

Physics and Society · Physics 2026-01-30 Fabio Mazza , Gabriele Ricci , Francesca Colaiori , Stefano Guarino , Sandro Meloni , Fabio Saracco

After the recent COVID-19 outbreaks, it became increasingly evident that individuals' thoughts and beliefs can have a strong impact on disease transmission. It becomes therefore important to understand how information and opinions on…

Physics and Society · Physics 2024-09-27 Giacomo Albi , Elisa Calzola , Giacomo Dimarco , Mattia Zanella

In some systems, the behavior of the constituent units can create a `context' that modifies the direct interactions among them. This mechanism of indirect modification inspired us to develop a minimal model of context-dependent spreading.…

Physics and Society · Physics 2023-06-13 Giulio Burgio , Sergio Gómez , Alex Arenas

Changs in individual behavior often entangles with the dynamic interaction of individuals, which complicates the epidemic process and brings great challenges for the understanding and control of the epidemic. In this work, we consider three…

Physics and Society · Physics 2021-10-27 Bing Wang , Zeyang Xie , Yuexing Han

This position paper discusses emerging behavioral, social, and economic dynamics related to the COVID-19 pandemic and puts particular emphasis on two emerging issues: First, delayed effects (or second strikes) of pandemics caused by dread…

Physics and Society · Physics 2020-09-04 Stephan Leitner

When an infectious disease propagates throughout society, the incidence function may rise at first due to an increase in pathogenicity and then decrease due to inhibitory effects until it reaches saturation. Effective vaccination and…

Dynamical Systems · Mathematics 2023-07-11 Sushil Pathak , G. Shirisha , K. Venkata Ratnam

As pathogens spread in a population of hosts, immunity is built up and the pool of susceptible individuals is depleted. This generates selective pressure, to which many human RNA viruses, such as influenza virus or SARS-CoV-2, respond with…

Populations and Evolution · Quantitative Biology 2024-08-29 Pierre Barrat-Charlaix , Richard A. Neher

Diseases spread through host populations over the networks of contacts between individuals, and a number of results about this process have been derived in recent years by exploiting connections between epidemic processes and bond…

Statistical Mechanics · Physics 2007-05-23 M. E. J. Newman

Infectious diseases are a significant threat to human society which was over sighted before the incidence of COVID-19, although according to the report of the World Health Organisation (WHO) about 4.2 million people die annually due to…

Physics and Society · Physics 2021-02-05 Md Shahzamal , Saeed Khan
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