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Baseline covariates in randomized experiments are often used in the estimation of treatment effects, for example, when estimating treatment effects within covariate-defined subgroups. In practice, however, covariate values may be missing…

Methodology · Statistics 2023-08-29 Gauri Kamat , Jerome P. Reiter

The imputation of the Multivariate time series (MTS) is particularly challenging since the MTS typically contains irregular patterns of missing values due to various factors such as instrument failures, interference from irrelevant data,…

Machine Learning · Computer Science 2025-04-04 Ye Su , Hezhe Qiao , Di Wu , Yuwen Chen , Lin Chen

Patients often discontinue treatment in a clinical trial because their health condition is not improving. Consequently, the patients still in the study at the end of the trial have better health outcomes on average than the initial patient…

Methodology · Statistics 2022-06-06 Alex Ocampo , Heinz Schmidli , Peter Quarg , Francesca Callegari , Marcello Pagano

Objective: Researchers often use model-based multiple imputation to handle missing at random data to minimize bias while making the best use of all available data. However, there are sometimes constraints within the data that make…

Methodology · Statistics 2020-11-03 Chinchin Wang , Tyrel Stokes , Russell Steele , Niels Wedderkopp , Ian Shrier

Missing data imputation is a fundamental problem in data analysis, and many studies have been conducted to improve its performance by exploring model structures and learning procedures. However, data augmentation, as a simple yet effective…

Machine Learning · Computer Science 2023-04-07 Yufeng Wang , Dan Li , Cong Xu , Min Yang

Targeted Maximum Likelihood Estimation (TMLE) is increasingly used for doubly robust causal inference, but how missing data should be handled when using TMLE with data-adaptive approaches is unclear. Based on the Victorian Adolescent Health…

Cost-Effectiveness Analyses (CEAs) alongside randomised controlled trials (RCTs) are increasingly often designed to collect resource use and preference-based health status data for the purpose of healthcare technology assessment. However,…

Applications · Statistics 2016-07-22 Andrea Gabrio , Alexina Mason , Gianluca Baio

Partially recorded data are frequently encountered in many applications and usually clustered by first removing incomplete cases or features with missing values, or by imputing missing values, followed by application of a clustering…

Methodology · Statistics 2021-10-20 Emily M. Goren , Ranjan Maitra

We evaluate the performance of targeted maximum likelihood estimation (TMLE) for estimating the average treatment effect in missing data scenarios under varying levels of positivity violations. We employ model- and design-based simulations,…

Methodology · Statistics 2026-05-12 Christoph Wiederkehr , Christian Heumann , Michael Schomaker

Multiple imputation (MI) is a popular method for handling missing data. Auxiliary variables can be added to the imputation model(s) to improve MI estimates. However, the choice of which auxiliary variables to include in the imputation model…

Although data may be abundant, complete data is less so, due to missing columns or rows. This missingness undermines the performance of downstream data products that either omit incomplete cases or create derived completed data for…

Machine Learning · Computer Science 2020-06-26 Haw-minn Lu , Giancarlo Perrone , José Unpingco

Datasets with missing values are very common in real world applications. GAIN, a recently proposed deep generative model for missing data imputation, has been proved to outperform many state-of-the-art methods. But GAIN only uses a…

Machine Learning · Computer Science 2021-04-07 Yufeng Wang , Dan Li , Xiang Li , Min Yang

This paper presents a new methodology to solve problems resulting from missing data in large-scale item performance behavioral databases. Useful statistics corrected for missing data are described, and a new method of imputation for missing…

Methodology · Statistics 2011-02-21 Pierre Courrieu , Arnaud Rey

Multiple imputation (MI) is a method for repairing and analyzing data with missing values. MI replaces missing values with a sample of random values drawn from an imputation model. The most popular form of MI, which we call posterior draw…

Methodology · Statistics 2019-11-18 Paul T. von Hippel , Jonathan Bartlett

In various biomedical studies, analysis often focuses on data magnitudes, particularly when algebraic signs are irrelevant or lost. For repeated measures studies involving magnitude outcomes, incorporating random effects is essential as…

Methodology · Statistics 2025-07-16 Wen Teng , Niall D. Ferguson , Ewan C. Goligher , Anna Heath

Missing data imputation remains a fundamental challenge in modern data science, especially when uncertainty quantification is essential. In this work, we propose MissBGM, an AI-powered missing data imputation method via Bayesian generative…

Machine Learning · Statistics 2026-05-05 Qiao Liu

A multivariate mixed-effects model seems to be the most appropriate for gene expression data collected in a crossover trial. It is, however, difficult to obtain reliable results using standard statistical inference when some responses are…

Methodology · Statistics 2023-09-12 Savita Pareek , Kalyan Das , Siuli Mukhopadhyay

Marginal structural models (MSMs) are commonly used to estimate causal intervention effects in longitudinal non-randomised studies. A common issue when analysing data from observational studies is the presence of incomplete confounder data,…

Methodology · Statistics 2019-12-02 Clemence Leyrat , James R Carpenter , Sebastien Bailly , Elizabeth J Willamson

Generative models play an important role in missing data imputation in that they aim to learn the joint distribution of full data. However, applying advanced deep generative models (such as Diffusion models) to missing data imputation is…

Machine Learning · Computer Science 2025-05-27 Hengrui Zhang , Liancheng Fang , Qitian Wu , Philip S. Yu

We propose a multiple imputation method to deal with incomplete categorical data. This method imputes the missing entries using the principal components method dedicated to categorical data: multiple correspondence analysis (MCA). The…

Methodology · Statistics 2015-06-01 Vincent Audigier , François Husson , Julie Josse
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