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Diffusion models have achieved promising results for Structure-Based Drug Design (SBDD). Nevertheless, high-quality protein subpocket and ligand data are relatively scarce, which hinders the models' generation capabilities. Recently, Direct…

Biomolecules · Quantitative Biology 2026-02-11 Xiwei Cheng , Xiangxin Zhou , Yuwei Yang , Yu Bao , Quanquan Gu

We present Diffusion-KTO, a novel approach for aligning text-to-image diffusion models by formulating the alignment objective as the maximization of expected human utility. Since this objective applies to each generation independently,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Shufan Li , Konstantinos Kallidromitis , Akash Gokul , Yusuke Kato , Kazuki Kozuka

Recent progress in generative diffusion models has greatly advanced text-to-video generation. While text-to-video models trained on large-scale, diverse datasets can produce varied outputs, these generations often deviate from user…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Runtao Liu , Haoyu Wu , Zheng Ziqiang , Chen Wei , Yingqing He , Renjie Pi , Qifeng Chen

This paper studies Distributionally Robust Optimization (DRO), a fundamental framework for enhancing the robustness and generalization of statistical learning and optimization. An effective ambiguity set for DRO must involve distributions…

Machine Learning · Computer Science 2025-10-28 Jiaqi Wen , Jianyi Yang

Preference learning is a key technology for aligning language models with human values. Reinforcement Learning from Human Feedback (RLHF) is a model-based algorithm to optimize preference learning, which first fits a reward model for…

Machine Learning · Computer Science 2024-03-26 Zaifan Jiang , Xing Huang , Chao Wei

Sequential recommendation (SR) models are typically trained on user-item interactions which are affected by the system exposure bias, leading to the user preference learned from the biased SR model not being fully consistent with the true…

Information Retrieval · Computer Science 2023-12-13 Jiyuan Yang , Yue Ding , Yidan Wang , Pengjie Ren , Zhumin Chen , Fei Cai , Jun Ma , Rui Zhang , Zhaochun Ren , Xin Xin

Reinforcement learning from human feedback (RLHF) plays a crucial role in aligning language models with human preferences. While the significance of dataset quality is generally recognized, explicit investigations into its impact within the…

Machine Learning · Computer Science 2024-12-04 Tetsuro Morimura , Mitsuki Sakamoto , Yuu Jinnai , Kenshi Abe , Kaito Ariu

Large language models in the past have typically relied on some form of reinforcement learning with human feedback (RLHF) to better align model responses with human preferences. However, because of oft-observed instabilities when…

Computation and Language · Computer Science 2024-07-15 Xiangkun Hu , Tong He , David Wipf

Diffusion models have achieved remarkable progress in text-to-image generation, yet aligning them with human preference remains challenging due to the presence of multiple, sometimes conflicting, evaluation metrics (e.g., semantic…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Dipesh Tamboli , Souradip Chakraborty , Aditya Malusare , Biplab Banerjee , Amrit Singh Bedi , Vaneet Aggarwal

Single-trajectory reinforcement learning (RL) methods aim to optimize policies from datasets consisting of (prompt, response, reward) triplets, where scalar rewards are directly available. This supervision format is highly practical, as it…

Machine Learning · Computer Science 2025-12-23 Bilal Faye , Hanane Azzag , Mustapha Lebbah

Recent advancements in human preference optimization, originally developed for Large Language Models (LLMs), have shown significant potential in improving text-to-image diffusion models. These methods aim to learn the distribution of…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Amir Saeidi , Yiran Luo , Agneet Chatterjee , Shamanthak Hegde , Bimsara Pathiraja , Yezhou Yang , Chitta Baral

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Machine Learning · Computer Science 2026-01-22 Yuhui Sun , Xiyao Wang , Zixi Li , YiTian Ding , Tianyang Ling , Jialuo Chen , Tianyi Yu , Zhenlong Yuan , Jinman Zhao

While large-scale unsupervised language models (LMs) learn broad world knowledge and some reasoning skills, achieving precise control of their behavior is difficult due to the completely unsupervised nature of their training. Existing…

Machine Learning · Computer Science 2024-07-31 Rafael Rafailov , Archit Sharma , Eric Mitchell , Stefano Ermon , Christopher D. Manning , Chelsea Finn

Direct alignment methods typically train large language models (LLMs) by contrasting the likelihoods of preferred and dispreferred responses. While effective at capturing relative preferences, these methods are widely observed to suppress…

Computation and Language · Computer Science 2025-12-04 Kaiyang Guo , Yinchuan Li , Zhitang Chen

We present Anchored Direct Preference Optimization (ADPO), a policy alignment method derived from first principles of KL-regularized reinforcement learning. Unlike standard approaches that treat the reference policy merely as a regularizer,…

Machine Learning · Computer Science 2026-01-13 Wang Zixian

We introduce a novel alignment method for diffusion models from distribution optimization perspectives while providing rigorous convergence guarantees. We first formulate the problem as a generic regularized loss minimization over…

Machine Learning · Computer Science 2025-03-07 Ryotaro Kawata , Kazusato Oko , Atsushi Nitanda , Taiji Suzuki

Direct Preference Optimization (DPO), which derives reward signals directly from pairwise preference data, has shown its effectiveness on aligning Large Language Models (LLMs) with human preferences. Despite its widespread use across…

Computation and Language · Computer Science 2024-04-09 Duanyu Feng , Bowen Qin , Chen Huang , Zheng Zhang , Wenqiang Lei

Recently, there has been significant interest in replacing the reward model in Reinforcement Learning with Human Feedback (RLHF) methods for Large Language Models (LLMs), such as Direct Preference Optimization (DPO) and its variants. These…

Computation and Language · Computer Science 2024-09-27 Jian Li , Haojing Huang , Yujia Zhang , Pengfei Xu , Xi Chen , Rui Song , Lida Shi , Jingwen Wang , Hao Xu

Neural retrieval models excel in Web search, but their training requires substantial amounts of labeled query-document pairs, which are costly to obtain. With the widespread availability of Web document collections like ClueWeb22, synthetic…

Information Retrieval · Computer Science 2025-05-27 João Coelho , Bruno Martins , João Magalhães , Chenyan Xiong

A critical component of the current generation of language models is preference alignment, which aims to precisely control the model's behavior to meet human needs and values. The most notable among such methods is Reinforcement Learning…

Artificial Intelligence · Computer Science 2024-10-22 Oh Joon Kwon , Daiki E. Matsunaga , Kee-Eung Kim
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