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Here we introduce Partially Observed Structural Causal Models (POSCMs) that formalize causal systems where latent contexts co-determine both the interaction structure and downstream mechanisms on observed variables. POSCMs provide an…

Machine Learning · Computer Science 2026-05-06 Turan Orujlu , Jordan Matelsky , Martin V. Butz , Charley M. Wu , Konrad P. Kording

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Zero-inflated continuous data ubiquitously appear in many fields, in which lots of exactly zero-valued data are observed while others distribute continuously. Due to the mixed structure of discreteness and continuity in its distribution,…

Methodology · Statistics 2024-10-28 Keita Hamamoto

This paper provides a comprehensive review of deep structural causal models (DSCMs), particularly focusing on their ability to answer counterfactual queries using observational data within known causal structures. It delves into the…

Machine Learning · Statistics 2025-02-04 Audrey Poinsot , Alessandro Leite , Nicolas Chesneau , Michèle Sébag , Marc Schoenauer

Differential equations are a ubiquitous tool to study dynamics, ranging from physical systems to complex systems, where a large number of agents interact through a graph with non-trivial topological features. Data-driven approximations of…

Statistical Mechanics · Physics 2024-04-26 Vaiva Vasiliauskaite , Nino Antulov-Fantulin

The ability to conduct interventions plays a pivotal role in learning causal relationships among variables, thus facilitating applications across diverse scientific disciplines such as genomics, economics, and machine learning. However, in…

Machine Learning · Statistics 2024-11-04 Abhinav Kumar , Kirankumar Shiragur , Caroline Uhler

Addressing missing data in complex datasets including electronic health records (EHR) is critical for ensuring accurate analysis and decision-making in healthcare. This paper proposes dynamically adaptable structural equation modeling (SEM)…

Machine Learning · Computer Science 2024-04-26 Ou Deng , Qun Jin

The original development of Shapley values for prediction explanation relied on the assumption that the features being described were independent. If the features in reality are dependent this may lead to incorrect explanations. Hence,…

Methodology · Statistics 2021-02-15 Kjersti Aas , Thomas Nagler , Martin Jullum , Anders Løland

Deep structured models are widely used for tasks like semantic segmentation, where explicit correlations between variables provide important prior information which generally helps to reduce the data needs of deep nets. However, current…

Machine Learning · Computer Science 2018-11-02 Colin Graber , Ofer Meshi , Alexander Schwing

Copulas are a fundamental tool for modelling multivariate dependencies in data, forming the method of choice in diverse fields and applications. However, the adoption of existing models for multimodal and high-dimensional dependencies is…

Machine Learning · Statistics 2026-05-20 David Huk , Theodoros Damoulas

Graphical models are an important tool in exploring relationships between variables in complex, multivariate data. Methods for learning such graphical models are well developed in the case where all variables are either continuous or…

Machine Learning · Statistics 2024-02-15 Konstantin Göbler , Anne Miloschewski , Mathias Drton , Sach Mukherjee

Causal diagrams are logic and graphical tools that depict assumptions about presumed causal relations. Such diagrams have proven effective in tackling a variety of problems in social sciences and epidemiology research yet remain foreign to…

Applications · Statistics 2023-06-29 M. Z. Naser

Copula models have become one of the most widely used tools in the applied modelling of multivariate data. Similarly, Bayesian methods are increasingly used to obtain efficient likelihood-based inference. However, to date, there has been…

Methodology · Statistics 2015-10-13 Michael Stanley Smith

Copulas, generalized estimating equations, and generalized linear mixed models promote the analysis of grouped data where non-normal responses are correlated. Unfortunately, parameter estimation remains challenging in these three…

Methodology · Statistics 2024-10-16 Sarah S. Ji , Benjamin B. Chu , Hua Zhou , Kenneth Lange

We develop estimation for potentially high-dimensional additive structural equation models. A key component of our approach is to decouple order search among the variables from feature or edge selection in a directed acyclic graph encoding…

Methodology · Statistics 2014-12-02 Peter Bühlmann , Jonas Peters , Jan Ernest

Summary statistics of genome-wide association studies (GWAS) teach causal relationship between millions of genetic markers and tens and thousands of phenotypes. However, underlying biological mechanisms are yet to be elucidated. We can…

Machine Learning · Statistics 2019-01-25 Yongjin Park , Abhishek Sarkar , Khoi Nguyen , Manolis Kellis

Analyses of causal mediation often involve exposure-induced confounders or, relatedly, multiple mediators. In such applications, researchers aim to estimate a variety of different quantities, including interventional direct and indirect…

Methodology · Statistics 2025-06-18 Jesse Zhou , Geoffrey T. Wodtke

Dynamic Bayesian networks provide a compact and natural representation for complex dynamic systems. However, in many cases, there is no expert available from whom a model can be elicited. Learning provides an alternative approach for…

Artificial Intelligence · Computer Science 2013-01-30 Xavier Boyen , Nir Friedman , Daphne Koller

We propose and demonstrate a joint model of anatomical shapes, image features and clinical indicators for statistical shape modeling and medical image analysis. The key idea is to employ a copula model to separate the joint dependency…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 Bernhard Egger , Markus D. Schirmer , Florian Dubost , Marco J. Nardin , Natalia S. Rost , Polina Golland

Structural equation modeling (SEM) is a statistical method for analyzing relationships among latent variables. Since SEM is a confirmatory method, the model needs to be specified in advance. In practice, however, statisticians have several…

Statistics Theory · Mathematics 2026-04-15 Shogo Kusano , Masayuki Uchida