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Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect…

Flow cytometry mainly used for detecting the characteristics of a number of biochemical substances based on the expression of specific markers in cells. It is particularly useful for detecting membrane surface receptors, antigens, ions, or…

Machine Learning · Computer Science 2023-03-17 Yanhua Xu

Accurate classification of blood cells plays a key role in improving automated blood analysis for both medical and veterinary applications. This work presents a two-stage deep clustering method for classifying blood cells from…

Quantitative Methods · Quantitative Biology 2025-09-25 Mihaela Macarie-Ancau , Adrian Groza

Human immune system contains white blood cells (WBC) that are good indicator of many diseases like bacterial infections, AIDS, cancer, spleen, etc. White blood cells have been sub classified into four types: monocytes, lymphocytes,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Rabia Asghar , Arslan Shaukat , Usman Akram , Rimsha Tariq

Circulating tumor cells (CTCs) are crucial biomarkers in liquid biopsy, offering a noninvasive tool for cancer patient management. However, their identification remains particularly challenging due to their limited number and heterogeneity.…

Image and Video Processing · Electrical Eng. & Systems 2025-11-24 Martina Russo , Giulia Bertolini , Vera Cappelletti , Cinzia De Marco , Serena Di Cosimo , Petra Paiè , Nadia Brancati

Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer…

Image and Video Processing · Electrical Eng. & Systems 2019-12-17 Wei Qiu , Jiaming Guo , Xiang Li , Mengjia Xu , Mo Zhang , Ning Guo , Quanzheng Li

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Sai Sukruth Bezugam

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Flow cytometry (FC) is a single-cell profiling platform for measuring the phenotypes of individual cells from millions of cells in biological samples. FC employs high-throughput technologies and generates high-dimensional data, and hence…

Quantitative Methods · Quantitative Biology 2015-01-16 Ariful Azad

Human blood primarily comprises plasma, red blood cells, white blood cells, and platelets. It plays a vital role in transporting nutrients to different organs, where it stores essential health-related data about the human body. Blood cells…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Rabia Asghar , Sanjay Kumar , Paul Hynds , Abeera Mahfooz

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

Computer-aided methods for analyzing white blood cells (WBC) have become widely popular due to the complexity of the manual process. Recent works have shown highly accurate segmentation and detection of white blood cells from microscopic…

Image and Video Processing · Electrical Eng. & Systems 2019-10-03 Changhun Jung , Mohammed Abuhamad , Jumabek Alikhanov , Aziz Mohaisen , Kyungja Han , DaeHun Nyang

The flow dynamics of red blood cells in vivo in blood capillaries and in vitro in microfluidic channels is complex. Cells can obtain differnet shapes such as discoid, parachute, slipper-like shapes and various intermediate states depending…

Biological Physics · Physics 2023-04-17 Andreas Link , a Irene Luna Pardo , Bernd Porr , Thomas Franke

A mixed suspension of red blood cells (RBCs) and microparticles flows through a cylindrical channel with a constriction mimicking a stenosed blood vessel. Our three-dimensional Lattice-Boltzmann simulations show that the RBCs are depleted…

Fluid Dynamics · Physics 2017-02-01 Christian Bächer , Lukas Schrack , Stephan Gekle

This paper proposes a novel automatic classification framework for the recognition of five types of white blood cells. Segmenting complete white blood cells from blood smears images and extracting advantageous features from them remain…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Na Dong , Meng-die Zhai , Jian-fang Chang , Chun-ho Wu

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monitoring. However, real-world WBC datasets present substantial appearance variations caused…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Luu Le , Hoang-Loc Cao , Ha-Hieu Pham , Thanh-Huy Nguyen , Ulas Bagci

We consider the use of the Joint Clustering and Matching (JCM) procedure for the supervised classification of a flow cytometric sample with respect to a number of predefined classes of such samples. The JCM procedure has been proposed as a…

Quantitative Methods · Quantitative Biology 2014-11-12 Sharon X. Lee , Geoffrey J. McLachlan , Saumyadipta Pyne

Automated red blood cell (RBC) classification on blood smear images helps hematologists to analyze RBC lab results in a reduced time and cost. However, overlapping cells can cause incorrect predicted results, and so they have to be…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Korranat Naruenatthanaset , Thanarat H. Chalidabhongse , Duangdao Palasuwan , Nantheera Anantrasirichai , Attakorn Palasuwan

Circulating Tumor Cells (CTCs) bear great promise as biomarkers in tumor prognosis. However, the process of identification and later enumeration of CTCs require manual labor, which is error-prone and time-consuming. The recent developments…

Computer Vision and Pattern Recognition · Computer Science 2022-08-08 Elena Alexander , Kam W. Leong , Andrew F. Laine

We present a method for a real time visualization and automatic processing for detection and classification of untouched cancer cells in blood during stain free imaging flow cytometry using digital holographic microscopy and machine…

Biological Physics · Physics 2021-06-15 Noga Nissim , Matan Dudaie , Itay Barnea. , Natan T. Shaked
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