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Variant calling is a fundamental task in genomic research, essential for detecting genetic variations such as single nucleotide polymorphisms (SNPs) and insertions or deletions (indels). This paper presents an enhancement to DeepChem, a…

Quantitative Methods · Quantitative Biology 2025-07-29 Ankita Vaishnobi Bisoi , Shreyas V , Jose Siguenza , Bharath Ramsundar

Incorporating group symmetries via equivariance into neural networks has emerged as a robust approach for overcoming the efficiency and data demands of modern deep learning. While most existing approaches, such as group convolutions and…

Machine learning force fields show great promise in enabling more accurate molecular dynamics simulations compared to manually derived ones. Much of the progress in recent years was driven by exploiting prior knowledge about physical…

Machine Learning · Computer Science 2025-09-11 Andreas Burger , Luca Thiede , Alán Aspuru-Guzik , Nandita Vijaykumar

The translation equivariance of convolutions can make convolutional neural networks translation equivariant or invariant. Equivariance to other transformations (e.g. rotations, affine transformations, scalings) may also be desirable as soon…

Signal Processing · Electrical Eng. & Systems 2021-05-05 Mateus Sangalli , Samy Blusseau , Santiago Velasco-Forero , Jesus Angulo

Despite their widespread success in various domains, Transformer networks have yet to perform well across datasets in the domain of 3D atomistic graphs such as molecules even when 3D-related inductive biases like translational invariance…

Machine Learning · Computer Science 2023-03-01 Yi-Lun Liao , Tess Smidt

Learning policies for multi-entity systems in 3D environments is far more complicated against single-entity scenarios, due to the exponential expansion of the global state space as the number of entities increases. One potential solution of…

Machine Learning · Computer Science 2024-07-18 Runfa Chen , Ling Wang , Yu Du , Tianrui Xue , Fuchun Sun , Jianwei Zhang , Wenbing Huang

Representation learning has become increasingly important, especially as powerful models have shifted towards learning latent representations before fine-tuning for downstream tasks. This approach is particularly valuable in leveraging the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-17 Shizhe He , Magdalini Paschali , Jiahong Ouyang , Adnan Masood , Akshay Chaudhari , Ehsan Adeli

In recent years the use of convolutional layers to encode an inductive bias (translational equivariance) in neural networks has proven to be a very fruitful idea. The successes of this approach have motivated a line of research into…

Subsampling is used in convolutional neural networks (CNNs) in the form of pooling or strided convolutions, to reduce the spatial dimensions of feature maps and to allow the receptive fields to grow exponentially with depth. However, it is…

Machine Learning · Computer Science 2021-06-11 Jin Xu , Hyunjik Kim , Tom Rainforth , Yee Whye Teh

Monocular 3D object parsing is highly desirable in various scenarios including occlusion reasoning and holistic scene interpretation. We present a deep convolutional neural network (CNN) architecture to localize semantic parts in 2D image…

Computer Vision and Pattern Recognition · Computer Science 2017-04-24 Chi Li , M. Zeeshan Zia , Quoc-Huy Tran , Xiang Yu , Gregory D. Hager , Manmohan Chandraker

We investigate Siamese networks for learning related embeddings for augmented samples of molecular conformers. We find that a non-contrastive (positive-pair only) auxiliary task aids in supervised training of Euclidean neural networks…

Machine Learning · Computer Science 2023-02-16 Michael Maser , Ji Won Park , Joshua Yao-Yu Lin , Jae Hyeon Lee , Nathan C. Frey , Andrew Watkins

The rapid progress of machine learning interatomic potentials over the past couple of years produced a number of new architectures. Particularly notable among these are the Atomic Cluster Expansion (ACE), which unified many of the earlier…

Rotation equivariance is a desirable property in many practical applications such as motion forecasting and 3D perception, where it can offer benefits like sample efficiency, better generalization, and robustness to input perturbations.…

Computer Vision and Pattern Recognition · Computer Science 2023-01-26 Serge Assaad , Carlton Downey , Rami Al-Rfou , Nigamaa Nayakanti , Ben Sapp

Molecular dynamic simulations are important in computational physics, chemistry, material, and biology. Machine learning-based methods have shown strong abilities in predicting molecular energy and properties and are much faster than DFT…

Molecular Networks · Quantitative Biology 2023-02-03 Zheng Yuan , Yaoyun Zhang , Chuanqi Tan , Wei Wang , Fei Huang , Songfang Huang

By folding into particular 3D structures, proteins play a key role in living beings. To learn meaningful representation from a protein structure for downstream tasks, not only the global backbone topology but the local fine-grained…

Biomolecules · Quantitative Biology 2025-02-05 Jiahan Li , Shitong Luo , Congyue Deng , Chaoran Cheng , Jiaqi Guan , Leonidas Guibas , Jian Peng , Jianzhu Ma

We describe generalizations of the universal approximation theorem for neural networks to maps invariant or equivariant with respect to linear representations of groups. Our goal is to establish network-like computational models that are…

Neural and Evolutionary Computing · Computer Science 2018-04-30 Dmitry Yarotsky

Molecular representation pretraining is critical in various applications for drug and material discovery due to the limited number of labeled molecules, and most existing work focuses on pretraining on 2D molecular graphs. However, the…

Machine Learning · Computer Science 2023-03-02 Shengchao Liu , Hongyu Guo , Jian Tang

Recent work has shown the utility of developing machine learning models that respect the structure and symmetries of eigenvectors. These works promote sign invariance, since for any eigenvector v the negation -v is also an eigenvector.…

Machine Learning · Computer Science 2023-12-06 Derek Lim , Joshua Robinson , Stefanie Jegelka , Haggai Maron

Carbohydrates, vital components of biological systems, are well-known for their structural diversity. Nuclear Magnetic Resonance (NMR) spectroscopy plays a crucial role in understanding their intricate molecular arrangements and is…

Machine Learning · Computer Science 2023-11-22 Maria Bånkestad , Keven M. Dorst , Göran Widmalm , Jerk Rönnols

Many theoretical results in deep learning can be traced to symmetry or equivariance of neural networks under parameter transformations. However, existing analyses are typically problem-specific and focus on first-order consequences such as…

Machine Learning · Computer Science 2025-12-29 Yongyi Yang , Liu Ziyin