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Existing machine learning methods for molecular (e.g., gene) embeddings are restricted to specific tasks or data modalities, limiting their effectiveness within narrow domains. As a result, they fail to capture the full breadth of gene…

Artificial intelligence for graphs has achieved remarkable success in modeling complex systems, ranging from dynamic networks in biology to interacting particle systems in physics. However, the increasingly heterogeneous graph datasets call…

Machine Learning · Computer Science 2023-01-25 Yasha Ektefaie , George Dasoulas , Ayush Noori , Maha Farhat , Marinka Zitnik

Recent advances in vision-language models have significantly expanded the frontiers of automated image analysis. However, applying these models in safety-critical contexts remains challenging due to the complex relationships between…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Muhammad Imran , Yugyung Lee

Neural methods of molecule property prediction require efficient encoding of structure and property relationship to be accurate. Recent work using graph algorithms shows limited generalization in the latent molecule encoding space. We build…

Quantitative Methods · Quantitative Biology 2020-11-26 Prateeth Nayak , Andrew Silberfarb , Ran Chen , Tulay Muezzinoglu , John Byrnes

Existing works based on molecular knowledge neglect the 3D geometric structure of molecules and fail to learn the high-dimensional information of medications, leading to structural confusion. Additionally, it does not extract key…

Machine Learning · Computer Science 2024-11-13 Shi Mu , Chen Li , Xiang Li , Shunpan Liang

The adoption of Deep Learning algorithms in the medical imaging field is a prominent area of research, with high potential for advancing AI-based Computer-aided diagnosis (AI-CAD) solutions. However, current solutions face challenges due to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-30 Iury B. de A. Santos , André C. P. L. F. de Carvalho

Although interpretable prototype networks have improved the transparency of deep learning image classification, the need for multiple prototypes in collaborative decision-making increases cognitive complexity and hinders user understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Yitao Peng , Lianghua He , Hongzhou Chen

Large Language Models (LLMs) have shown remarkable capabilities in processing various data structures, including graphs. While previous research has focused on developing textual encoding methods for graph representation, the emergence of…

Machine Learning · Computer Science 2024-09-16 Zhiqiang Zhong , Davide Mottin

We view molecular optimization as a graph-to-graph translation problem. The goal is to learn to map from one molecular graph to another with better properties based on an available corpus of paired molecules. Since molecules can be…

Machine Learning · Computer Science 2019-01-30 Wengong Jin , Kevin Yang , Regina Barzilay , Tommi Jaakkola

Multimodal Large Language Models (MLLMs) have demonstrated remarkable capabilities in representing and understanding diverse modalities. However, they typically focus on modality alignment in a pairwise manner while overlooking structural…

Machine Learning · Computer Science 2025-06-13 Jiajin Liu , Dongzhe Fan , Jiacheng Shen , Chuanhao Ji , Daochen Zha , Qiaoyu Tan

Molecular Property Prediction (MPP) plays a pivotal role across diverse domains, spanning drug discovery, material science, and environmental chemistry. Fueled by the exponential growth of chemical data and the evolution of artificial…

Machine Learning · Computer Science 2024-08-23 Tanya Liyaqat , Tanvir Ahmad , Chandni Saxena

Understanding molecular structure and related knowledge is crucial for scientific research. Recent studies integrate molecular graphs with their textual descriptions to enhance molecular representation learning. However, they focus on the…

Artificial Intelligence · Computer Science 2025-06-02 Yibo Li , Yuan Fang , Mengmei Zhang , Chuan Shi

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

Machine Learning · Computer Science 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao

The integration of deep learning, particularly AI-Generated Content, with high-quality data derived from ab initio calculations has emerged as a promising avenue for transforming the landscape of scientific research. However, the challenge…

Machine Learning · Computer Science 2024-12-11 Kaiwei Zhang , Yange Lin , Guangcheng Wu , Yuxiang Ren , Xuecang Zhang , Bo wang , Xiaoyu Zhang , Weitao Du

How to effectively represent molecules is a long-standing challenge for molecular property prediction and drug discovery. This paper studies this problem and proposes to incorporate chemical domain knowledge, specifically related to…

Machine Learning · Computer Science 2023-05-04 Liang Zeng , Lanqing Li , Jian Li

Designing accurate deep learning models for molecular property prediction plays an increasingly essential role in drug and material discovery. Recently, due to the scarcity of labeled molecules, self-supervised learning methods for learning…

Biomolecules · Quantitative Biology 2022-06-08 Han Li , Dan Zhao , Jianyang Zeng

Vision-Language Models (VLMs) have shown strong performance in tasks like visual question answering and multimodal text generation, but their effectiveness in scientific domains such as materials science remains limited. While some machine…

Machine Learning · Computer Science 2025-11-11 An Vuong , Minh-Hao Van , Prateek Verma , Chen Zhao , Xintao Wu

Prediction of toxicity levels of chemical compounds is an important issue in Quantitative Structure-Activity Relationship (QSAR) modeling. Although toxicity prediction has achieved significant progress in recent times through deep learning,…

Machine Learning · Computer Science 2019-07-22 Abdul Karim , Jaspreet Singh , Avinash Mishra , Abdollah Dehzangi , M. A. Hakim Newton , Abdul Sattar

Multimodal learning has been a field of increasing interest, aiming to combine various modalities in a single joint representation. Especially in the area of visiolinguistic (VL) learning multiple models and techniques have been developed,…

Machine Learning · Computer Science 2024-03-26 Maria Lymperaiou , Giorgos Stamou

Learning holistic computational representations in physical, chemical or biological systems requires the ability to process information from different distributions and modalities within the same model. Thus, the demand for multimodal…

Machine Learning · Computer Science 2025-04-17 Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik
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