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Proxy variables are commonly used in causal inference when unmeasured confounding exists. While most existing proximal methods assume a unidirectional causal relationship between two primary variables, many social and biological systems…

Methodology · Statistics 2025-07-21 Jiaqi Min , Xueyue Zhang , Shanshan Luo

We develop a likelihood-based inference for finite-state birth-death processes with composite birth rates, in which multiple distinct mechanisms contribute additively to the total birth intensity. Our main motivating example is an SIS…

Statistics Theory · Mathematics 2026-04-23 Marko Lalovic , Nicos Georgiou , Istvan Z. Kiss

Epidemiological models are best suitable to model an epidemic if the spread pattern is stationary. To deal with non-stationary patterns and multiple waves of an epidemic, we develop a hybrid model encompassing epidemic modeling, particle…

Machine Learning · Computer Science 2024-02-01 Naresh Kumar , Seba Susan

The investment of time and resources for better strategies and methodologies to tackle a potential pandemic is key to deal with potential outbreaks of new variants or other viruses in the future. In this work, we recreated the scene of a…

Machine Learning · Computer Science 2021-04-22 Andrés L. Suárez-Cetrulo , Ankit Kumar , Luis Miralles-Pechuán

In this paper, we propose a parameter identification methodology of the SIRD model, an extension of the classical SIR model, that considers the deceased as a separate category. In addition, our model includes one parameter which is the…

Machine Learning · Computer Science 2023-08-10 Marian Petrica , Ionel Popescu

We propose a high dimensional Bayesian inference framework for learning heterogeneous dynamics of a COVID-19 model, with a specific application to the dynamics and severity of COVID-19 inside and outside long-term care (LTC) facilities. We…

Methodology · Statistics 2021-08-04 Peng Chen , Keyi Wu , Omar Ghattas

Traditionally, the identification of parameters in the formulation and solution of inverse problems considers that models, variables and mathematical parameters are free of uncertainties. This aspect simplifies the estimation process, but…

Populations and Evolution · Quantitative Biology 2020-06-02 Gustavo Barbosa Libotte , Fran Sérgio Lobato , Gustavo Mendes Platt

Causal effect moderation investigates how the effect of interventions (or treatments) on outcome variables changes based on observed characteristics of individuals, known as potential effect moderators. With advances in data collection,…

Methodology · Statistics 2024-11-26 Soham Bakshi , Walter Dempsey , Snigdha Panigrahi

The relative case fatality rates (CFRs) between groups and countries are key measures of relative risk that guide policy decisions regarding scarce medical resource allocation during the ongoing COVID-19 pandemic. In the middle of an active…

Quantitative Methods · Quantitative Biology 2022-12-08 Anastasios Nikolas Angelopoulos , Reese Pathak , Rohit Varma , Michael I. Jordan

Adjusting for covariates is a well established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study there may be different adjustment…

Statistics Theory · Mathematics 2021-04-27 Jack Kuipers , Giusi Moffa

In epidemiology, identifying the effect of exposure variables in relation to a time-to-event outcome is a classical research area of practical importance. Incorporating propensity score in the Cox regression model, as a measure to control…

Methodology · Statistics 2019-06-11 Yingrui Yang , Molin Wang

In recent decades, event studies have emerged as a central methodology in health and social research for evaluating the causal effects of staggered interventions. In this paper, we analyze event studies from experimental design principles…

Methodology · Statistics 2024-11-25 Zhu Shen , Ambarish Chattopadhyay , Yuzhou Lin , Jose R. Zubizarreta

Machine learning applications for longitudinal electronic health records often forecast the risk of events at fixed time points, whereas survival analysis achieves dynamic risk prediction by estimating time-to-event distributions. Here, we…

Machine Learning · Computer Science 2024-11-26 Munib Mesinovic , Peter Watkinson , Tingting Zhu

There are nowadays a huge load of publications about dengue epidemic models, which mostly employ deterministic differential equations. The analytical properties of deterministic models are always of particular interest by many experts, but…

Dynamical Systems · Mathematics 2017-11-15 Karunia Putra Wijaya , Thomas Goetz

The estimate of the remaining time of an ongoing wave of epidemic spreading is a critical issue. Due to the variations of a wide range of parameters in an epidemic, for simple models such as Susceptible-Infected-Removed (SIR) model, it is…

Populations and Evolution · Quantitative Biology 2021-10-12 Anvesh Reddy , Hanesh Koganti , Sai Krishna , Suhas Reddy , Soumyajyoti Biswas

Numerous COVID-19 clinical decision support systems have been developed. However many of these systems do not have the merit for validity due to methodological shortcomings including algorithmic bias. Methods Logistic regression models were…

Machine Learning · Computer Science 2021-11-02 Yifan Li , Garrett Yoon , Mustafa Nasir-Moin , David Rosenberg , Sean Neifert , Douglas Kondziolka , Eric Karl Oermann

The SARS-CoV-2 pandemic has caused significant mortality and morbidity worldwide, sparing almost no community. As the disease will likely remain a threat for years to come, an understanding of the precise influences of human demographics…

Populations and Evolution · Quantitative Biology 2020-07-02 Niayesh Afshordi , Benjamin Holder , Mohammad Bahrami , Daniel Lichtblau

The abundance of modern health data provides many opportunities for the use of machine learning techniques to build better statistical models to improve clinical decision making. Predicting time-to-event distributions, also known as…

Machine Learning · Statistics 2020-12-15 Zidi Xiu , Chenyang Tao , Benjamin A. Goldstein , Ricardo Henao

Risk management is particularly concerned with extreme events, but analysing these events is often hindered by the scarcity of data, especially in a multivariate context. This data scarcity complicates risk management efforts. Various tools…

Methodology · Statistics 2026-01-15 Nisrine Madhar , Juliette Legrand , Maud Thomas

It is well recognised that animal and plant pathogens form complex ecological communities of interacting organisms within their hosts. Although community ecology approaches have been applied to determine pathogen interactions at the…

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