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Multi-omics studies often rely on pathway enrichment to interpret heterogeneous molecular changes, but pathway enrichment (PE)-based workflows inherit structural limitations of pathway resources, including curation lag, functional…

Computation and Language · Computer Science 2026-01-01 Sibo Wei , Peng Chen , Lifeng Dong , Yin Luo , Lei Wang , Peng Zhang , Wenpeng Lu , Jianbin Guo , Hongjun Yang , Dajun Zeng

The identification of reproducible biological patterns from high-dimensional data is a bottleneck for understanding the biology of complex illnesses such as schizophrenia. To address this, we developed a biologically informed, multi-stage…

Quantitative Methods · Quantitative Biology 2017-12-04 Junfang Chen , Emanuel Schwarz

Misinformation in healthcare, from vaccine hesitancy to unproven treatments, poses risks to public health and trust in medical systems. While machine learning and natural language processing have advanced automated fact-checking, validating…

Computation and Language · Computer Science 2025-09-18 Mariano Barone , Antonio Romano , Giuseppe Riccio , Marco Postiglione , Vincenzo Moscato

When addressing professional questions in the biomedical domain, humans typically acquire multiple pieces of information as evidence and engage in multifaceted analysis to provide high-quality answers. Current LLM-based question answering…

Computation and Language · Computer Science 2025-09-03 Chang Zong , Jian Wan , Siliang Tang , Lei Zhang

Understanding mechanistic relationships among genes and their impacts on biological pathways is essential for elucidating disease mechanisms and advancing precision medicine. Despite the availability of extensive molecular interaction and…

Molecular Networks · Quantitative Biology 2026-03-24 Fujian Jia , Jiwen Gu , Cheng Lu , Dezhi Zhao , Mengjiang Huang , Yuanzhi Lu , Xin Liu , Kang Liu

Motivation: The mapping of RNA-seq reads to their transcripts of origin is a fundamental task in transcript expression estimation and differential expression scoring. Where ambiguities in mapping exist due to transcripts sharing sequence,…

Genomics · Quantitative Biology 2015-01-28 James Hensman , Peter Glaus , Antti Honkela , Magnus Rattray

Laboratory workflows in pharmaceutical and biomedical research encode substantial tacit knowledge -- expert judgment about failure conditions, decision branching logic, and contextual dependencies -- that remains inaccessible to protocol…

In this paper, we introduce SciGen, a new challenge dataset for the task of reasoning-aware data-to-text generation consisting of tables from scientific articles and their corresponding descriptions. Describing scientific tables goes beyond…

Computation and Language · Computer Science 2021-04-20 Nafise Sadat Moosavi , Andreas Rücklé , Dan Roth , Iryna Gurevych

Large language models (LLMs) incorporated with Retrieval-Augmented Generation (RAG) have demonstrated powerful capabilities in generating counterspeech against misinformation. However, current studies rely on limited evidence and offer less…

Computation and Language · Computer Science 2025-09-16 Anirban Saha Anik , Xiaoying Song , Elliott Wang , Bryan Wang , Bengisu Yarimbas , Lingzi Hong

Engineered image-based biomarkers offer a clinically interpretable alternative to black-box AI in computational pathology, yet their discovery remains largely intuition-driven, guided by fragmented literature rather than rigorous biological…

Knowledge Graph-based Question Answering (KGQA) plays a pivotal role in complex reasoning tasks but remains constrained by two persistent challenges: the structural heterogeneity of Knowledge Graphs(KGs) often leads to semantic mismatch…

Computation and Language · Computer Science 2026-05-19 Peng Yu , En Xu , Bin Chen , Haibiao Chen , Yinfei Xu

Developing accurate biomedical Question Answering (QA) systems in low-resource languages remains a major challenge, limiting equitable access to reliable medical knowledge. This paper introduces BanglaMedQA and BanglaMMedBench, the first…

Computation and Language · Computer Science 2025-11-07 Sadia Sultana , Saiyma Sittul Muna , Mosammat Zannatul Samarukh , Ajwad Abrar , Tareque Mohmud Chowdhury

Understanding causal heterogeneity is essential for scientific discovery in domains such as biology and medicine. However, existing methods lack causal awareness, with insufficient modeling of heterogeneity, confounding, and observational…

Machine Learning · Computer Science 2025-10-29 Wenrui Li , Qinghao Zhang , Xiaowo Wang

We present a scalable, AI-powered system that identifies and extracts evidence-based behavioral nudges from unstructured biomedical literature. Nudges are subtle, non-coercive interventions that influence behavior without limiting choice,…

Referring Expression Comprehension (REC) is a popular multimodal task that aims to accurately detect target objects within a single image based on a given textual expression. However, due to the limitations of earlier models, traditional…

Machine Learning · Computer Science 2025-08-21 Guanghao Jin , Jingpei Wu , Tianpei Guo , Yiyi Niu , Weidong Zhou , Guoyang Liu

Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers, uncertainty, and retrievable…

Deep neural networks have achieved strong performance in genomic sequence classification; however, relating their predictions to biologically meaningful sequence patterns remains challenging. In this work, we present AttnGen, an…

Machine Learning · Computer Science 2026-05-15 Rayhaneh Shabani Nia , Ali Karkehabadi

Retrieval-Augmented Generation (RAG) effectively reduces hallucinations in Large Language Models (LLMs) but can still produce inconsistent or unsupported content. Although LLM-as-a-Judge is widely used for RAG hallucination detection due to…

Computation and Language · Computer Science 2025-02-27 Zhouyu Jiang , Mengshu Sun , Zhiqiang Zhang , Lei Liang

Biomedical entity linking (BEL) is the task of grounding entity mentions to a knowledge base. It plays a vital role in information extraction pipelines for the life sciences literature. We review recent work in the field and find that, as…

Computation and Language · Computer Science 2023-08-23 Samuele Garda , Leon Weber-Genzel , Robert Martin , Ulf Leser

While sequential reasoning enhances the capability of Vision-Language Models (VLMs) to execute complex multimodal tasks, their reliability in grounding these reasoning chains within actual visual evidence remains insufficiently explored. We…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Rory Driscoll , Alexandros Christoforos , Chadbourne Davis