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Machine learning accelerates molecular property prediction, yet state-of-the-art Large Language Models and Graph Neural Networks operate as black boxes. In drug discovery, where safety is critical, this opacity risks masking false…

Machine Learning · Computer Science 2026-03-03 Oscar Rivera , Ziqing Wang , Matthieu Dagommer , Abhishek Pandey , Kaize Ding

This paper addresses explainable AI (XAI) through the lens of Concept Bottleneck Models (CBMs) that do not require explicit concept annotations, relying instead on concepts extracted using CLIP in a zero-shot manner. We show that CLIP,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Rémi Kazmierczak , Steve Azzolin , Eloïse Berthier , Goran Frehse , Gianni Franchi

Deep Neural Networks (DNNs) are often considered black boxes due to their opaque decision-making processes. To reduce their opacity Concept Models (CMs), such as Concept Bottleneck Models (CBMs), were introduced to predict human-defined…

Human-Computer Interaction · Computer Science 2025-12-02 Jack Furby , Dan Cunnington , Dave Braines , Alun Preece

As AI models grow larger, the demand for accountability and interpretability has become increasingly critical for understanding their decision-making processes. Concept Bottleneck Models (CBMs) have gained attention for enhancing…

Machine Learning · Computer Science 2024-10-10 Angelos Ragkousis , Sonali Parbhoo

We are concerned with the challenge of reliably classifying and assessing intracranial aneurysms using deep learning without compromising clinical transparency. While traditional black-box models achieve high predictive accuracy, their lack…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Toqa Khaled , Ahmad Al-Kabbany

Concept-based explanation methods, such as concept bottleneck models (CBMs), aim to improve the interpretability of machine learning models by linking their decisions to human-understandable concepts, under the critical assumption that such…

Artificial Intelligence · Computer Science 2025-02-03 Halil Ibrahim Aysel , Xiaohao Cai , Adam Prugel-Bennett

Concept Bottleneck Models (CBMs) and other concept-based interpretable models show great promise for making AI applications more transparent, which is essential in fields like medicine. Despite their success, we demonstrate that CBMs…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Jessica Bader , Leander Girrbach , Stephan Alaniz , Zeynep Akata

Concept Bottleneck Model (CBM) is a methods for explaining neural networks. In CBM, concepts which correspond to reasons of outputs are inserted in the last intermediate layer as observed values. It is expected that we can interpret the…

Machine Learning · Statistics 2024-03-15 Naoki Hayashi , Yoshihide Sawada

Concept-based eXplainable AI (C-XAI) is a rapidly growing research field that enhances AI model interpretability by leveraging intermediate, human-understandable concepts. This approach not only enhances model transparency but also enables…

Machine Learning · Computer Science 2025-04-08 Francesco De Santis , Gabriele Ciravegna , Philippe Bich , Danilo Giordano , Tania Cerquitelli

Catastrophic forgetting remains a fundamental challenge in continual learning, in which models often forget previous knowledge when fine-tuned on a new task. This issue is especially pronounced in class incremental learning (CIL), which is…

Machine Learning · Computer Science 2026-04-17 Amirhosein Javadi , Tuomas Oikarinen , Tara Javidi , Tsui-Wei Weng

Concept Bottleneck Models (CBMs) predict through human-interpretable concepts, but they typically output point concept probabilities that conflate epistemic uncertainty (reducible model underspecification) with aleatoric uncertainty…

Artificial Intelligence · Computer Science 2026-04-28 Tanmoy Mukherjee , Thomas Bailleux , Pierre Marquis , Zied Bouraoui

Recent concept-based interpretable models have succeeded in providing meaningful explanations by pre-defined concept sets. However, the dependency on the pre-defined concepts restricts the application because of the limited number of…

Artificial Intelligence · Computer Science 2025-02-19 Shin'ya Yamaguchi , Kosuke Nishida

Concept Bottleneck Models (CBMs) aim to enhance interpretability by structuring predictions around human-understandable concepts. However, unintended information leakage, where predictive signals bypass the concept bottleneck, compromises…

Machine Learning · Computer Science 2025-07-22 Mikael Makonnen , Moritz Vandenhirtz , Sonia Laguna , Julia E Vogt

We introduce the Concept Bottleneck Large Language Model (CB-LLM), a pioneering approach to creating inherently interpretable Large Language Models (LLMs). Unlike traditional black-box LLMs that rely on post-hoc interpretation methods with…

Computation and Language · Computer Science 2024-07-08 Chung-En Sun , Tuomas Oikarinen , Tsui-Wei Weng

Concept bottleneck models (CBM) aim to improve model interpretability by predicting human level "concepts" in a bottleneck within a deep learning model architecture. However, how the predicted concepts are used in predicting the target…

Machine Learning · Computer Science 2025-04-15 Matthew Shen , Aliyah Hsu , Abhineet Agarwal , Bin Yu

The opaque nature of Large Language Models (LLMs) has led to significant research efforts aimed at enhancing their interpretability, primarily through post-hoc methods. More recent in-hoc approaches, such as Concept Bottleneck Models…

Machine Learning · Computer Science 2025-02-20 Or Raphael Bidusa , Shaul Markovitch

The main challenges hindering the adoption of deep learning-based systems in clinical settings are the scarcity of annotated data and the lack of interpretability and trust in these systems. Concept Bottleneck Models (CBMs) offer inherent…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Cristiano Patrício , Luís F. Teixeira , João C. Neves

Large, publicly available clinical datasets have emerged as a novel resource for understanding disease heterogeneity and to explore personalization of therapy. These datasets are derived from data not originally collected for research…

Machine Learning · Computer Science 2025-08-14 Anish Narain , Ritam Majumdar , Nikita Narayanan , Dominic Marshall , Sonali Parbhoo

Concept bottleneck models (CBMs) ensure interpretability by decomposing predictions into human interpretable concepts. Yet the annotations used for training CBMs that enable this transparency are often noisy, and the impact of such…

Machine Learning · Computer Science 2026-02-02 Seonghwan Park , Jueun Mun , Donghyun Oh , Namhoon Lee

Interpreting and explaining the behavior of deep neural networks is critical for many tasks. Explainable AI provides a way to address this challenge, mostly by providing per-pixel relevance to the decision. Yet, interpreting such…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Bowen Wang , Liangzhi Li , Yuta Nakashima , Hajime Nagahara
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