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AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

Quantum optimization allows for up to exponential quantum speedups for specific, possibly industrially relevant problems. As the key algorithm in this field, we motivate and discuss the Quantum Approximate Optimization Algorithm (QAOA),…

Quantum Physics · Physics 2025-11-18 Jonas Stein , Maximilian Zorn , Leo Sünkel , Thomas Gabor

Grover's algorithm can be employed in global optimization methods providing, in some cases, a quadratic speedup over classical algorithms. This paper describes a new method for continuous global optimization problems that uses a classical…

Optimization and Control · Mathematics 2013-01-22 Pedro Lara , Renato Portugal , Carlile Lavor

We assess the potential of quantum computing to accelerate computation of central tasks in genomics, focusing on often-neglected theoretical limitations. We discuss state-of-the-art challenges of quantum search, optimization, and machine…

Quantum Physics · Physics 2026-01-09 Aurora Maurizio , Guglielmo Mazzola

We report the implementation of Grover's quantum search algorithm in the scalable system of trapped atomic ion quantum bits. Any one of four possible states of a two-qubit memory is marked, and following a single query of the search space,…

Quantum Physics · Physics 2009-11-11 K. -A. Brickman , P. C. Haljan , P. J. Lee , M. Acton , L. Deslauriers , C. Monroe

Amplitude Amplification -- a key component of Grover's Search algorithm -- uses an iterative approach to systematically increase the probability of one or multiple target states. We present novel strategies to enhance the amplification…

Quantum Physics · Physics 2021-06-22 Austin Gilliam , Marco Pistoia , Constantin Gonciulea

We present a quantum feature-selection framework based on a higher-order unconstrained binary optimization (HUBO) formulation that explicitly incorporates multivariate dependencies beyond standard quadratic encodings. In contrast to…

We propose a general, fully gate-based quantum algorithm for counterdiabatic driving. The algorithm does not depend on heuristics as in previous variational methods, and exploits regularisation of the adiabatic gauge potential to suppress…

Quantum Physics · Physics 2024-10-10 Dyon van Vreumingen

Quantum computation promises to provide substantial speedups in many practical applications with a particularly exciting one being the simulation of quantum many-body systems. Adiabatic state preparation (ASP) is one way that quantum…

Quantum Physics · Physics 2022-01-05 Vladimir Kremenetski , Carlos Mejuto-Zaera , Stephen J. Cotton , Norm M. Tubman

Grover's algorithm searches for data satisfying a desired condition in an unstructured database. This algorithm can search a space of size $N$ in $\sqrt{N}$ queries, thereby achieving a quadratic speedup. However, within the Grover oracle…

Quantum Physics · Physics 2026-04-09 Yusuke Kimura , Yutaka Takita

Distributed quantum computing offers a potential solution to the complexity of superconducting chip hardware layouts and error correction algorithms. High-quality gates between distributed chips enable the simplification of existing error…

Quantum Physics · Physics 2025-11-04 Yunan Li , Xi Zhang , Weixin Zhang , Ruonan Guo , Yu Zhang , Xinsheng Tan , Yang Yu

In this work, we present a multi-layer quantum search method that generates an exponential speedup of the standard Grover's algorithm. As direct applications, any NP problems can be solved efficiently on a quantum circuit with only…

Quantum Physics · Physics 2020-04-28 Shan Jin , Xiaoting Wang , Bo Li

Quantum processors are potentially superior to their classical counterparts for many computational tasks including factorization. Circuit methods as well as adiabatic methods have already been proposed and implemented for finding the…

Quantum Physics · Physics 2019-09-25 Soham Pal , Saranyo Moitra , V. S. Anjusha , Anil Kumar , T. S. Mahesh

We demonstrate the possibility of (sub)exponential quantum speedup via a quantum algorithm that follows an adiabatic path of a gapped Hamiltonian with no sign problem. This strengthens the superpolynomial separation recently proved by…

Quantum Physics · Physics 2020-11-20 András Gilyén , Umesh Vazirani

The Hubbard model has occupied the minds of condensed matter physicists for most part of the last century. This model provides insight into a range of phenomena in correlated electron systems. We wish to examine the paradigm of quantum…

Quantum Physics · Physics 2026-05-12 Kunal Vyas , Fengping Jin , Hans De Raedt , Kristel Michielsen

The main approach to hybrid quantum-classical neural networks (QNN) is employing quantum computing to build a neural network (NN) that has quantum features, which is then optimized classically. Here, we propose a different strategy: to use…

Quantum Physics · Physics 2025-04-22 Stefan-Alexandru Jura , Mihai Udrescu

Today, hardware constraints are an important limitation on quantum adiabatic optimization algorithms. Firstly, computational problems must be formulated as quadratic unconstrained binary optimization (QUBO) in the presence of noisy coupling…

Quantum Physics · Physics 2018-12-06 Andrew Lucas

We give a quantum speedup for solving the canonical semidefinite programming relaxation for binary quadratic optimization. This class of relaxations for combinatorial optimization has so far eluded quantum speedups. Our methods combine…

Data Structures and Algorithms · Computer Science 2022-01-26 Fernando G. S L. Brandão , Richard Kueng , Daniel Stilck França

Finding a maximum or minimum is a fundamental building block in many mathematical models. Compared with classical algorithms, Durr, Hoyer's quantum algorithm (DHA) achieves quadratic speed. However, its key step, the quantum exponential…

Quantum Physics · Physics 2019-08-22 Yanhu Chen , Shijie Wei , Xiong Gao , Cen Wang , Jian Wu , Hongxiang Guo

Spin qubits in silicon are strong contenders for realizing a practical quantum computer. This technology has made remarkable progress with the demonstration of single and two-qubit gates above the fault-tolerant threshold and entanglement…