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In this paper we discuss Grover Adaptive Search (GAS) for Constrained Polynomial Binary Optimization (CPBO) problems, and in particular, Quadratic Unconstrained Binary Optimization (QUBO) problems, as a special case. GAS can provide a…

Quantum Physics · Physics 2021-06-08 Austin Gilliam , Stefan Woerner , Constantin Gonciulea

Protein design is a technique to engineer proteins by modifying their sequence to obtain novel functionalities. In this method, amino acids in the sequence are permutated to find the low energy states satisfying the configuration. However,…

Quantitative Methods · Quantitative Biology 2023-05-10 Mohammad Hassan Khatami , Udson C. Mendes , Nathan Wiebe , Philip M. Kim

In this paper, we propose a novel method of formulating an NP-hard wireless channel assignment problem as a higher-order unconstrained binary optimization (HUBO), where the Grover adaptive search (GAS) is used to provide a quadratic speedup…

Quantum Physics · Physics 2023-08-02 Yuki Sano , Masaya Norimoto , Naoki Ishikawa

Grover adaptive search (GAS) is a quantum exhaustive search algorithm designed to solve binary optimization problems. In this paper, we propose higher-order binary formulations that can simultaneously reduce the numbers of qubits and gates…

Quantum Physics · Physics 2024-05-14 Yuki Sano , Kosuke Mitarai , Naoki Yamamoto , Naoki Ishikawa

Quantum approaches to combinatorial optimization problems (COPs) are often limited by the resource demands of Quadratic Unconstrained Binary Optimization (QUBO) encodings, which enlarge circuits through penalty terms and increase qubit and…

Quantum Physics · Physics 2025-11-25 Frederik Koch , Shahram Panahiyan , Rick Mukherjee , Joseph Doetsch , Dieter Jaksch

The advent of quantum computing processors with possibility to scale beyond experimental capacities magnifies the importance of studying their applications. Combinatorial optimization problems can be one of the promising applications of…

Quantum Physics · Physics 2017-08-18 Ehsan Zahedinejad , Arman Zaribafiyan

It has previously been established that adiabatic quantum computation, operating based on a continuous Zeno effect due to dynamical phases between eigenstates, is able to realise an optimal Grover-like quantum speedup. In other words, is…

Quantum Physics · Physics 2024-11-20 Jesse Berwald , Nick Chancellor , Raouf Dridi

The Quantum Approximate Optimization Algorithm (QAOA) is among leading candidates for achieving quantum advantage on near-term processors. While typically implemented with a transverse-field mixer (XM-QAOA), the Grover-mixer variant…

Quantum Physics · Physics 2026-01-01 Evgeniy O. Kiktenko , Elizaveta V. Krendeleva , Aleksey K. Fedorov

We present a quantum algorithm that has rigorous runtime guarantees for several families of binary optimization problems, including Quadratic Unconstrained Binary Optimization (QUBO), Ising spin glasses ($p$-spin model), and $k$-local…

Simulated annealing (SA) is a key algorithm for solving combinatorial optimization problems, which model numerous real-world systems. While SA is commonly used to solve quadratic unconstrained binary optimization (QUBO) problems, many…

Statistical Mechanics · Physics 2026-05-05 Kohei Suzuki

We demonstrate that the search space of the quadratic assignment problem (QAP), known as an NP-hard combinatorial optimization problem, can be reduced using Grover adaptive search (GAS) with permutation preparation operator (PPO). To that…

Quantum control optimization algorithms are routinely used to generate optimal quantum gates or efficient quantum state transfers. However, there are two main challenges in designing efficient optimization algorithms, namely overcoming the…

Quantum Physics · Physics 2022-02-02 Priya Batra , M. Harshanth Ram , T. S. Mahesh

Cardinality-constrained binary optimization is a fundamental computational primitive with broad applications in machine learning, finance, and scientific computing. In this work, we introduce a Grover-based quantum algorithm that exploits…

Quantum Physics · Physics 2026-03-17 Haomu Yuan , Hanqing Wu , Kuan-Cheng Chen , Bin Cheng , Crispin H. W. Barnes

In this paper, we propose a quantum algorithm that supports a real-valued higher-order unconstrained binary optimization (HUBO) problem. This algorithm is based on the Grover adaptive search that originally supported HUBO with integer…

Signal Processing · Electrical Eng. & Systems 2023-02-17 Masaya Norimoto , Ryuhei Mori , Naoki Ishikawa

We investigate the use of amplitude amplification on the gate-based model of quantum computing as a means for solving combinatorial optimization problems. This study focuses primarily on QUBO (quadratic unconstrained binary optimization)…

Quantum Physics · Physics 2023-02-02 Daniel Koch , Massimiliano Cutugno , Saahil Patel , Laura Wessing , Paul M. Alsing

This paper proposes Genetic Algorithm with Border Trades (GAB), a novel modification of the standard genetic algorithm that enhances exploration by incorporating new chromosome patterns in the breeding process. This approach significantly…

Machine Learning · Computer Science 2025-06-27 Qingchuan Lyu

Quantum annealing aims at solving optimization problems of practical relevance using quantum-computing hardware. Problems of interest are typically formulated in terms of quadratic unconstrained binary optimization (QUBO) Hamiltonians.…

A pivotal task for quantum computing is to speed up solving problems that are both classically intractable and practically valuable. Among these, combinatorial optimization problems have attracted tremendous attention due to their broad…

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

Here we explore which heuristic quantum algorithms for combinatorial optimization might be most practical to try out on a small fault-tolerant quantum computer. We compile circuits for several variants of quantum accelerated simulated…

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