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Precision therapeutics require multimodal adaptive models that generate personalized treatment recommendations. We introduce TxAgent, an AI agent that leverages multi-step reasoning and real-time biomedical knowledge retrieval across a…

Artificial Intelligence · Computer Science 2025-03-17 Shanghua Gao , Richard Zhu , Zhenglun Kong , Ayush Noori , Xiaorui Su , Curtis Ginder , Theodoros Tsiligkaridis , Marinka Zitnik

While Large Language Models (LLMs) have demonstrated significant advancements in reasoning and agent-based problem-solving, current evaluation methodologies fail to adequately assess their capabilities: existing benchmarks either rely on…

Graphical User Interface (GUI) Agents, powered by multimodal large language models (MLLMs), have shown great potential for task automation on computing devices such as computers and mobile phones. However, existing agents face challenges in…

Artificial Intelligence · Computer Science 2025-01-09 Yuhang Liu , Pengxiang Li , Zishu Wei , Congkai Xie , Xueyu Hu , Xinchen Xu , Shengyu Zhang , Xiaotian Han , Hongxia Yang , Fei Wu

Humans solve problems by executing targeted plans, yet large language models (LLMs) remain unreliable for structured workflow execution. We propose RunAgent, a multi-agent plan execution platform that interprets natural-language plans while…

Machine Learning · Computer Science 2026-05-04 Arunabh Srivastava , Mohammad A. , Khojastepour , Srimat Chakradhar , Sennur Ulukus

Large Language Models (LLMs) have demonstrated remarkable capabilities in reasoning and generation, serving as the foundation for advanced persona simulation and Role-Playing Language Agents (RPLAs). However, achieving authentic alignment…

Computation and Language · Computer Science 2026-04-20 Xintao Wang , Jian Yang , Weiyuan Li , Rui Xie , Jen-tse Huang , Jun Gao , Shuai Huang , Yueping Kang , Yuanli Gou , Hongwei Feng , Yanghua Xiao

Long-horizon household tasks demand robust high-level planning and sustained reasoning capabilities, which are largely overlooked by existing embodied AI benchmarks that emphasize short-horizon navigation or manipulation and rely on fixed…

Artificial Intelligence · Computer Science 2026-05-19 Zilin Zhu , Longteng Guo , Yanghong Mei , Bowen Pang , Zongxun Zhang , Xingjian He , Ruyi Ji , Jing Liu

Recent advances in large language models have enabled AI systems to achieve expert-level performance on domain-specific scientific tasks, yet these systems remain narrow and handcrafted. We introduce SciAgent, a unified multi-agent system…

Aligning agentic AI with user intent is critical for delegating complex, socially embedded tasks, yet user preferences are often implicit, evolving, and difficult to specify upfront. We present DoubleAgents, a system for human-agent…

Human-Computer Interaction · Computer Science 2026-04-07 Tao Long , Xuanming Zhang , Sitong Wang , Zhou Yu , Lydia B Chilton

Due to the advantages in the cost-efficiency and reproducibility, user simulation has become a promising solution to the user-centric evaluation of information retrieval systems. Nonetheless, accurately simulating user search behaviors has…

Information Retrieval · Computer Science 2024-10-30 Erhan Zhang , Xingzhu Wang , Peiyuan Gong , Yankai Lin , Jiaxin Mao

Large Language Model (LLM) empowered agents have recently emerged as advanced paradigms that exhibit impressive capabilities in a wide range of domains and tasks. Despite their potential, current LLM agents often adopt a one-size-fits-all…

While Multimodal Large Language Models (MLLMs) show immense promise for achieving truly human-like interactions, progress is hindered by the lack of fine-grained evaluation frameworks for human-centered scenarios, encompassing both the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Zheng Qin , Ruobing Zheng , Yabing Wang , Tianqi Li , Yi Yuan , Jingdong Chen , Le Wang

Egocentric AI agents, such as smart glasses, rely on pointing gestures to resolve referential ambiguities in natural language commands. However, despite advancements in Multimodal Large Language Models (MLLMs), current systems often fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Chentao Li , Zirui Gao , Mingze Gao , Yinglian Ren , Jianjiang Feng , Jie Zhou

Evaluation insights are limited by the availability of high-quality benchmarks. As models evolve, there is a need to create benchmarks that can measure progress on new and complex generative capabilities. However, manually creating new…

Machine Learning · Computer Science 2025-10-08 Natasha Butt , Varun Chandrasekaran , Neel Joshi , Besmira Nushi , Vidhisha Balachandran

Recent advances in large language models (LLMs) have led to remarkable progress across domains, yet their capabilities in the humanities, particularly history, remain underexplored. Historical reasoning poses unique challenges for AI,…

Existing benchmarks for AI reasoning provide limited insight into how closely these capabilities resemble human reasoning in naturalistic contexts. We present an adaptation of the Watson & Holmes detective tabletop game as a new benchmark…

Artificial Intelligence · Computer Science 2026-02-24 Thatchawin Leelawat , Lewis D Griffin

The pace of scientific research, vital for improving human life, is complex, slow, and needs specialized expertise. Meanwhile, novel, impactful research often stems from both a deep understanding of prior work, and a cross-pollination of…

Computation and Language · Computer Science 2025-02-11 Jinheon Baek , Sujay Kumar Jauhar , Silviu Cucerzan , Sung Ju Hwang

We observe that MLRMs oriented toward human-centric service are highly susceptible to user emotional cues during the deep-thinking stage, often overriding safety protocols or built-in safety checks under high emotional intensity. Inspired…

Artificial Intelligence · Computer Science 2025-08-07 Yuan Xun , Xiaojun Jia , Xinwei Liu , Hua Zhang

An essential problem in artificial intelligence is whether LLMs can simulate human cognition or merely imitate surface-level behaviors, while existing datasets suffer from either synthetic reasoning traces or population-level aggregation,…

Computation and Language · Computer Science 2026-03-31 Yuxuan Gu , Lunjun Liu , Xiaocheng Feng , Kun Zhu , Weihong Zhong , Lei Huang , Bing Qin

Reasoning about the behaviour of physical objects is a key capability of agents operating in physical worlds. Humans are very experienced in physical reasoning while it remains a major challenge for AI. To facilitate research addressing…

Artificial Intelligence · Computer Science 2021-08-31 Cheng Xue , Vimukthini Pinto , Chathura Gamage , Peng Zhang , Jochen Renz

As we consider entrusting Large Language Models (LLMs) with key societal and decision-making roles, measuring their alignment with human cognition becomes critical. This requires methods that can assess how these systems represent…

Artificial Intelligence · Computer Science 2025-10-03 Mattson Ogg , Ritwik Bose , Jamie Scharf , Christopher Ratto , Michael Wolmetz