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Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Retrieval-Augmented Generation (RAG) aims to reduce hallucination by grounding answers in retrieved evidence, yet hallucinated answers remain common even when relevant documents are available. Existing evaluations focus on answer-level or…

Computation and Language · Computer Science 2026-05-21 Passant Elchafei , Monorama Swain , Shahed Masoudian , Markus Schedl

Medical question-answering (QA) systems can benefit from advances in large language models (LLMs), but directly applying LLMs to the clinical domain poses challenges such as maintaining factual accuracy and avoiding hallucinations. In this…

Computation and Language · Computer Science 2025-12-08 Tasnimul Hassan , Md Faisal Karim , Haziq Jeelani , Elham Behnam , Robert Green , Fayeq Jeelani Syed

Retrieval-Augmented Generation (RAG) significantly improves the factuality of Large Language Models (LLMs), yet standard pipelines often lack mechanisms to verify inter- mediate reasoning, leaving them vulnerable to hallucinations in…

Computation and Language · Computer Science 2026-03-12 Eeham Khan , Luis Rodriguez , Marc Queudot

Retrieval-augmented generation (RAG) appears as a promising method to alleviate the "hallucination" problem in large language models (LLMs), since it can incorporate external traceable resources for response generation. The essence of RAG…

Computation and Language · Computer Science 2024-10-16 Haosheng Qian , Yixing Fan , Ruqing Zhang , Jiafeng Guo

The rapid advancement of large language models (LLMs) has significantly impacted various domains, including healthcare and biomedicine. However, the phenomenon of hallucination, where LLMs generate outputs that deviate from factual accuracy…

Computation and Language · Computer Science 2024-08-27 Duy Khoa Pham , Bao Quoc Vo

Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

Information Retrieval · Computer Science 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Retrieval augmented generation (RAG) systems provide a method for factually grounding the responses of a Large Language Model (LLM) by providing retrieved evidence, or context, as support. Guided by this context, RAG systems can reduce…

Information Retrieval · Computer Science 2025-09-05 Shakiba Amirshahi , Amin Bigdeli , Charles L. A. Clarke , Amira Ghenai

Retrieval-Augmented Generation (RAG) has emerged as a crucial approach for enhancing the responses of large language models (LLMs) with external knowledge sources. Despite the impressive performance in complex question-answering tasks, RAG…

Information Retrieval · Computer Science 2025-10-14 Haosheng Qian , Yixing Fan , Jiafeng Guo , Ruqing Zhang , Qi Chen , Dawei Yin , Xueqi Cheng

Retrieval-augmented Generation (RAG) has demonstrated potential in enhancing medical question-answering systems through the integration of large language models (LLMs) with external medical literature. LLMs can retrieve relevant medical…

Computation and Language · Computer Science 2025-10-29 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bin Qin

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

Retrieval Augmented Generation (RAG) has emerged as a promising solution to address hallucination issues in Large Language Models (LLMs). However, the integration of multiple retrieval sources, while potentially more informative, introduces…

Information Retrieval · Computer Science 2025-08-12 Wenlong Wu , Haofen Wang , Bohan Li , Peixuan Huang , Xinzhe Zhao , Lei Liang

Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…

Computation and Language · Computer Science 2025-05-27 Yuxing Lu , Gecheng Fu , Wei Wu , Xukai Zhao , Sin Yee Goi , Jinzhuo Wang

Retrieval-augmented generation (RAG) improves large language models (LLMs) by using external knowledge to guide response generation, reducing hallucinations. However, RAG, particularly multi-modal RAG, can introduce new hallucination…

Machine Learning · Computer Science 2025-01-08 Matin Mortaheb , Mohammad A. Amir Khojastepour , Srimat T. Chakradhar , Sennur Ulukus

The emergent abilities of large language models (LLMs) have demonstrated great potential in solving medical questions. They can possess considerable medical knowledge, but may still hallucinate and are inflexible in the knowledge updates.…

Computation and Language · Computer Science 2024-10-14 Guangzhi Xiong , Qiao Jin , Xiao Wang , Minjia Zhang , Zhiyong Lu , Aidong Zhang

Large Language Models (LLMs)-based question answering (QA) systems play a critical role in modern AI, demonstrating strong performance across various tasks. However, LLM-generated responses often suffer from hallucinations, unfaithful…

Computation and Language · Computer Science 2026-01-29 Yuqing Zhao , Ziyao Liu , Yongsen Zheng , Kwok-Yan Lam

Despite the potential of Large Language Models (LLMs) in medicine, they may generate responses lacking supporting evidence or based on hallucinated evidence. While Retrieval Augment Generation (RAG) is popular to address this issue, few…

While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation…

Computation and Language · Computer Science 2024-02-26 Guangzhi Xiong , Qiao Jin , Zhiyong Lu , Aidong Zhang

Medical question answering requires extensive access to specialized conceptual knowledge. The current paradigm, Retrieval-Augmented Generation (RAG), acquires expertise medical knowledge through large-scale corpus retrieval and uses this…

Computation and Language · Computer Science 2025-02-20 Sichu Liang , Linhai Zhang , Hongyu Zhu , Wenwen Wang , Yulan He , Deyu Zhou
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