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The unprecedented availability of large-scale datasets in neuroscience has spurred the exploration of artificial deep neural networks (DNNs) both as empirical tools and as models of natural neural systems. Their appeal lies in their ability…

Computational Engineering, Finance, and Science · Computer Science 2024-03-22 Ahmed ElGazzar , Marcel van Gerven

Scientific Machine Learning is a new class of approaches that integrate physical knowledge and mechanistic models with data-driven techniques for uncovering governing equations of complex processes. Among the available approaches, Universal…

Machine Learning · Statistics 2024-06-14 Nina Schmid , David Fernandes del Pozo , Willem Waegeman , Jan Hasenauer

Universal differential equations (UDEs) leverage the respective advantages of mechanistic models and artificial neural networks and combine them into one dynamic model. However, these hybrid models can suffer from unrealistic solutions,…

Quantitative Methods · Quantitative Biology 2024-12-05 Maren Philipps , Antonia Körner , Jakob Vanhoefer , Dilan Pathirana , Jan Hasenauer

Inverse problems involving differential equations often require identifying unknown parameters or functions from data. Existing approaches, such as Physics-Informed Neural Networks (PINNs), Universal Differential Equations (UDEs) and…

Machine Learning · Computer Science 2025-05-23 Shalev Manor , Mohammad Kohandel

In the last decade, the scientific community has devolved its attention to the deployment of data-driven approaches in scientific research to provide accurate and reliable analysis of a plethora of phenomena. Most notably, Physics-informed…

Machine Learning · Computer Science 2023-06-21 Mattia Silvestri , Federico Baldo , Eleonora Misino , Michele Lombardi

Complex dynamic systems are typically either modeled using expert knowledge in the form of differential equations or via data-driven universal approximation models such as artificial neural networks (ANN). While the first approach has…

Optimization and Control · Mathematics 2024-09-09 Christoph Plate , Carl Julius Martensen , Sebastian Sager

Universal Differential Equations (UDEs), which blend neural networks with physical differential equations, have emerged as a powerful framework for scientific machine learning (SciML), enabling data-efficient, interpretable, and physically…

Machine Learning · Computer Science 2025-06-11 Tarushri N. S.

Equations, particularly differential equations, are fundamental for understanding natural phenomena and predicting complex dynamics across various scientific and engineering disciplines. However, the governing equations for many complex…

Machine Learning · Computer Science 2025-04-15 Junfeng Chen , Kailiang Wu , Dongbin Xiu

Augmenting mechanistic ordinary differential equation (ODE) models with machine-learnable structures is an novel approach to create highly accurate, low-dimensional models of engineering systems incorporating both expert knowledge and…

Dynamical Systems · Mathematics 2022-06-22 Sandor Beregi , David A. W. Barton , Djamel Rezgui , Simon A. Neild

A chemical reaction network (CRN) is composed of reactions that can be seen as interactions among entities called species, which exist within the system. Endowed with kinetics, CRN has a corresponding set of ordinary differential equations…

Dynamical Systems · Mathematics 2021-04-20 Bryan S. Hernandez , Ralph John L. De la Cruz

Modeling complex dynamical systems with only partial knowledge of their physical mechanisms is a crucial problem across all scientific and engineering disciplines. Purely data-driven approaches, which only make use of an artificial neural…

Fluid Dynamics · Physics 2023-10-04 Nilam Tathawadekar , Nguyen Anh Khoa Doan , Camilo F. Silva , Nils Thuerey

Simulations of complex physical systems are typically realized by discretizing partial differential equations (PDEs) on unstructured meshes. While neural networks have recently been explored for surrogate and reduced order modeling of PDE…

Machine Learning · Computer Science 2021-10-27 Jiayang Xu , Aniruddhe Pradhan , Karthik Duraisamy

In chemical reaction network theory, ordinary differential equations are used to model the temporal change of chemical species concentration. As the functional form of these ordinary differential equations systems is derived from an…

Molecular Networks · Quantitative Biology 2025-02-27 Anna C. M. Thöni , William E. Robinson , Yoram Bachrach , Wilhelm T. S. Huck , Tal Kachman

Fractional Differential Equations (FDEs) are essential tools for modelling complex systems in science and engineering. They extend the traditional concepts of differentiation and integration to non-integer orders, enabling a more precise…

Machine Learning · Computer Science 2025-03-27 C. Coelho , M. Fernanda P. Costa , L. L. Ferrás

Recent years have witnessed a growth in mathematics for deep learning--which seeks a deeper understanding of the concepts of deep learning with mathematics and explores how to make it more robust--and deep learning for mathematics, where…

Machine Learning · Computer Science 2023-10-31 Derick Nganyu Tanyu , Jianfeng Ning , Tom Freudenberg , Nick Heilenkötter , Andreas Rademacher , Uwe Iben , Peter Maass

Accurate prediction of diverse chemical properties is crucial for advancing molecular design and materials discovery. Here we present a versatile approach that uses the intermediate information of a universal neural network potential as a…

Quantum Physics · Physics 2024-07-17 Tomoya Shiota , Kenji Ishihara , Wataru Mizukami

Partial Differential Equations (PDE) are fundamental to model different phenomena in science and engineering mathematically. Solving them is a crucial step towards a precise knowledge of the behaviour of natural and engineered systems. In…

The conjoining of dynamical systems and deep learning has become a topic of great interest. In particular, neural differential equations (NDEs) demonstrate that neural networks and differential equation are two sides of the same coin.…

Machine Learning · Computer Science 2022-02-08 Patrick Kidger

Chemical reactions occur in energy, environmental, biological, and many other natural systems, and the inference of the reaction networks is essential to understand and design the chemical processes in engineering and life sciences. Yet,…

Molecular Networks · Quantitative Biology 2021-01-22 Weiqi Ji , Sili Deng

Embedding computation in biochemical environments incompatible with traditional electronics is expected to have wide-ranging impact in synthetic biology, medicine, nanofabrication and other fields. Natural biochemical systems are typically…

Machine Learning · Computer Science 2022-06-15 Marko Vasic , Cameron Chalk , Austin Luchsinger , Sarfraz Khurshid , David Soloveichik
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