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While most of the studies on molecular machines have been performed in solution, interfacing these supramolecular systems with solid-state nanostructures and materials is very important in view of their utilization in sensing components…

Efficient machine learning inference is essential for the rapid adoption of artificial intelligence across various domains.On-chip optical computing has emerged as a transformative solution for accelerating machine learning tasks, owing to…

The application of closed-loop approaches in systems neuroscience and therapeutic stimulation holds great promise for revolutionizing our understanding of the brain and for developing novel neuromodulation therapies to restore lost…

Signal Processing · Electrical Eng. & Systems 2021-10-12 Bingzhao Zhu , Uisub Shin , Mahsa Shoaran

Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to its partially coherent illumination and common path…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Yuheng Jiao , Yuchen R. He , Mikhail E. Kandel , Xiaojun Liu , Wenlong Lu , Gabriel Popescu

Nanopores in two-dimensional (2D) materials, including graphene, can be used for a variety of applications, such as gas separations, water desalination, and DNA sequencing. So far, however, all plausible isomeric shapes of graphene…

Materials Science · Physics 2023-08-24 Sneha Thomas , Kevin S. Silmore , Ananth Govind Rajan

Resistive pulse sensing is used to characterize and count single particles in solution moving through channels under an electric bias, with nanoscale pores providing enough spatial resolution for single-molecule identification and…

Applied Physics · Physics 2025-10-16 Martin Charron , Zachary Roelen , Deekshant Wadhwa , Vincent Tabard-Cossa

Longitudinal resolution and lateral sensitivity are decisive characteristics that determine the suitability of a nanopore sensor for sequencing a strand of DNA as well as other important polymers. Previous modeling of DNA induced ionic…

Biological Physics · Physics 2012-05-18 Slaven Garaj , Song Liu , Daniel Branton , Jene A. Golovchenko

In the emerging field of molecular communication (MC), testbeds are needed to validate theoretical concepts, motivate applications, and guide further modeling efforts. To this end, this paper presents a flexible and extendable in-vessel…

The last decade, nanopores have emerged as a new and interesting tool for the study of biological macromolecules like proteins and DNA. While biological pores, especially alpha-hemolysin, have been promising for the detection of DNA, their…

Biological Physics · Physics 2015-03-13 Ronald Kox , Stella Deheryan , Chang Chen , Nima Arjmandi , Liesbet Lagae , Gustaaf Borghs

A microscopic physical analysis of the various resistive effects involved in the electronic detection of single biomolecules in a nanopore of a MoS2 nanoribbon is presented. The analysis relies on a combined experimental-theoretical…

Mesoscale and Nanoscale Physics · Physics 2020-04-23 Mingye Xiong , Michael Graf , Nagendra Athreya , Aleksandra Radenovic , Jean-Pierre Leburton

Efficient detection of harmful organic volatile compounds is a major health and environmental need in industrialized societies. Tailor-made metal-organic frameworks and other coordination polymers are emerging as promising sensing molecular…

Nanopore-based sensing platforms have transformed single-molecule detection and analysis. The foundation of nanopore translocation experiments lies in conductance measurements, yet existing models, which are largely phenomenological, are…

Biological Physics · Physics 2023-12-19 Arjav Shah , Shakul Pathak , Slaven Garaj , Martin Z. Bazant , Ankur Gupta , Patrick S. Doyle

Mixed Integer Programming (MIP) solvers rely on an array of sophisticated heuristics developed with decades of research to solve large-scale MIP instances encountered in practice. Machine learning offers to automatically construct better…

Molecular Communications (MC), transferring information via chemical signals, holds promise for transformative healthcare applications within the Internet of Bio-Nano Things (IoBNT) framework. Despite promising advances toward practical MC…

Emerging Technologies · Computer Science 2025-02-03 Maide Miray Albay , Eren Akyol , Fariborz Mirlou , Levent Beker , Murat Kuscu

On-chip optical interconnect has been widely accepted as a promising technology to realize future large-scale multiprocessors. Mode-division multiplexing (MDM) provides a new degree of freedom for optical interconnects to dramatically…

Optics · Physics 2020-04-07 Chunlei Sun , Yunhong Ding , Zhen Li , Wei Qi , Yu Yu , Xinliang Zhang

Polymers, composed of repeating structural units called monomers, are fundamental materials in daily life and industry. Accurate property prediction for polymers is essential for their design, development, and application. However, existing…

Machine Learning · Computer Science 2025-07-29 Jiaxi Wang , Yaosen Min , Xun Zhu , Miao Li , Ji Wu

Ultrathin nanopore membranes based on 2D materials have demonstrated ultimate resolution toward DNA sequencing. Among them, molybdenum disulphide (MoS2) shows long-term stability as well as superior sensitivity enabling high throughput…

Soft Condensed Matter · Physics 2023-07-19 J. Feng , K. Liu , M. Graf , M. Lihter , R. D. Bulushev , D. Dumcenco , D. T. L. Alexander , D. Krasnozhon , T. Vuletic , A. Kis , A. Radenovic

We demonstrate multimode optomechanical sensing of individual nanoparticles with radius of a hundred of nanometers. A semiconductor optomechanical disk resonator is optically driven and detected under ambient conditions, as nebulized…

On-chip spatial and polarization multiplexing have emerged as a powerful strategy to boost the bandwidth of integrated optical transceivers. State-of-the-art multiplexers require accurate control of the relative phase or the spatial…

This study presents the first implementation of multilayer neural networks on a memristor/CMOS integrated system on chip (SoC) to simultaneously detect multiple diseases. To overcome limitations in medical data, generative AI techniques are…

Hardware Architecture · Computer Science 2024-10-22 Zihan Wang , Daniel W. Yang , Zerui Liu , Evan Yan , Heming Sun , Ning Ge , Miao Hu , Wei Wu