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Denoising diffusion models have emerged as the go-to generative framework for solving inverse problems in imaging. A critical concern regarding these models is their performance on out-of-distribution tasks, which remains an under-explored…

Computer Vision and Pattern Recognition · Computer Science 2025-01-29 Riccardo Barbano , Alexander Denker , Hyungjin Chung , Tae Hoon Roh , Simon Arridge , Peter Maass , Bangti Jin , Jong Chul Ye

Diffusion-based image generators are promising priors for ill-posed inverse problems like sparse-view X-ray Computed Tomography (CT). As most studies consider synthetic data, it is not clear whether training data mismatch (``domain shift'')…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Nelas J. Thomsen , Xinyuan Wang , Felix Lucka , Ezgi Demircan-Tureyen

Deep learning-based reconstruction of positron emission tomography(PET) data has gained increasing attention in recent years. While these methods achieve fast reconstruction,concerns remain regarding quantitative accuracy and the presence…

PET super-resolution is highly under-constrained because paired multi-resolution scans from the same subject are rarely available, and effective resolution is determined by scanner-specific physics (e.g., PSF, detector geometry, and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Liutao Yang , Zi Wang , Peiyuan Jing , Xiaowen Wang , Javier A. Montoya-Zegarra , Kuangyu Shi , Daoqiang Zhang , Guang Yang

Multi-modal foundation models are typically trained on millions of pairs of natural images and text captions, frequently obtained through web-crawling approaches. Although such models depict excellent generative capabilities, they do not…

Computer Vision and Pattern Recognition · Computer Science 2023-01-03 Pierre Chambon , Christian Bluethgen , Curtis P. Langlotz , Akshay Chaudhari

Diffusion models (DMs) have recently been introduced as a regularizing prior for PET image reconstruction, integrating DMs trained on high-quality PET images with unsupervised schemes that condition on measured data. While these approaches…

Medical Physics · Physics 2026-03-18 George Webber , Alexander Hammers , Andrew P King , Andrew J Reader

Deep MRI reconstruction is commonly performed with conditional models that de-alias undersampled acquisitions to recover images consistent with fully-sampled data. Since conditional models are trained with knowledge of the imaging operator,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Alper Güngör , Salman UH Dar , Şaban Öztürk , Yilmaz Korkmaz , Gokberk Elmas , Muzaffer Özbey , Tolga Çukur

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Tengyue Zhang , Ruiwen Ding , Luoting Zhuang , Yuxiao Wu , Erika F. Rodriguez , William Hsu

Positron emission tomography (PET) is widely utilized for cancer detection due to its ability to visualize functional and biological processes in vivo. PET images are usually reconstructed from histogrammed raw data (sinograms) using…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yiran Sun , Osama Mawlawi

Diffusion models have demonstrated impressive abilities in generating photo-realistic and creative images. To offer more controllability for the generation process, existing studies, termed as early-constraint methods in this paper,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Chang Liu , Rui Li , Kaidong Zhang , Xin Luo , Dong Liu

Diffusion models has underpinned much recent advances of dataset augmentation in various computer vision tasks. However, when involving generating multi-object images as real scenarios, most existing methods either rely entirely on text…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Haoyu Wang , Lei Zhang , Wei Wei , Chen Ding , Yanning Zhang

Positron Emission Tomography (PET) image reconstruction is inherently challenged by Poisson noise and physical degradation factors, which are further exacerbated in limited-angle acquisitions. While deep learning methods demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Rüveyda Yilmaz , Yuli Wu , Johannes Stegmaier , Volkmar Schulz

Conditional generative models typically demand large annotated training sets to achieve high-quality synthesis. As a result, there has been significant interest in designing models that perform plug-and-play generation, i.e., to use a…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Nithin Gopalakrishnan Nair , Anoop Cherian , Suhas Lohit , Ye Wang , Toshiaki Koike-Akino , Vishal M. Patel , Tim K. Marks

Deep learning has significantly advanced PET image re-construction, achieving remarkable improvements in image quality through direct training on sinogram or image data. Traditional methods often utilize masks for inpainting tasks, but…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Bin Huang , Binzhong He , Yanhan Chen , Zhili Liu , Xinyue Wang , Binxuan Li , Qiegen Liu

Cross-modal image translation remains brittle and inefficient. Standard diffusion approaches often rely on a single, global linear transfer between domains. We find that this shortcut forces the sampler to traverse off-manifold, high-cost…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Zihao Wang , Yuzhou Chen , Shaogang Ren

This study introduces a novel approach for image reconstruction based on a diffusion model conditioned on the native data domain. Our method is applied to multi-coil MRI and quantitative MRI reconstruction, leveraging the domain-conditioned…

Machine Learning · Computer Science 2023-09-06 Wanyu Bian , Albert Jang , Fang Liu

Diffusion models have demonstrated remarkable generative capabilities in image processing tasks. We propose a Sparse condition Temporal Rewighted Integrated Distribution Estimation guided diffusion model (STRIDE) for sparse-view CT…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Zekun Zhou , Yanru Gong , Liu Shi , Qiegen Liu

The recent success of transformer-based image generative models in object-centric learning highlights the importance of powerful image generators for handling complex scenes. However, despite the high expressiveness of diffusion models in…

Computer Vision and Pattern Recognition · Computer Science 2023-11-06 Jindong Jiang , Fei Deng , Gautam Singh , Sungjin Ahn

Radiation hazards associated with standard-dose positron emission tomography (SPET) images remain a concern, whereas the quality of low-dose PET (LPET) images fails to meet clinical requirements. Therefore, there is great interest in…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Jiaqi Cui , Xinyi Zeng , Pinxian Zeng , Bo Liu , Xi Wu , Jiliu Zhou , Yan Wang

Scaling by training on large datasets has been shown to enhance the quality and fidelity of image generation and manipulation with diffusion models; however, such large datasets are not always accessible in medical imaging due to cost and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-14 Yousef Yeganeh , Azade Farshad , Ioannis Charisiadis , Marta Hasny , Martin Hartenberger , Björn Ommer , Nassir Navab , Ehsan Adeli
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