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Electrocardiogram (ECG)-based models have achieved strong performance in diagnostic tasks, yet they remain limited in modeling how cardiac dynamics evolve under external interventions. In particular, existing approaches focus primarily on…

Artificial Intelligence · Computer Science 2026-05-19 Zhikang Chen , Yue Wang , Sen Cui , Yu Zhang , Changshui Zhang , Tianling Ren , Tingting Zhu

The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a scaffold, providing structural support to cells as well as…

The Extracellular-Membrane-Intracellular (EMI) model is a novel mathematical framework for cardiac electrophysiology simulations. The EMI model provides a more detailed description of the heart's electrical activity compared to traditional…

Numerical Analysis · Mathematics 2025-04-29 Carlos Ballesteros , Alexei Cheviakov , Raymond J. Spiteri

In vivo, eukaryotic cells are embedded in a matrix environment, where they grow and develop. Generally, this extracellular matrix (ECM) is an anisotropic fibrous structure, through which macromolecules and biochemical signaling molecules at…

Biological Physics · Physics 2020-01-06 David Gomez , Sari Natan , Yair Shokef , Ayelet Lesman

Background: Conventional electrocardiogram (ECG) analysis faces a persistent dichotomy: expert-driven features ensure interpretability but lack sensitivity to latent patterns, while deep learning offers high accuracy but functions as a…

Quantitative Methods · Quantitative Biology 2026-01-23 Deyun Zhang , Jun Li , Shijia Geng , Yue Wang , Shijie Chen , Sumei Fan , Qinghao Zha , Shenda Hong

Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the alignment and stretching of constituent fibers within the vicinity of cells. As a consequence, the matrix reorganizes to form thick bundles of aligned…

Cell Behavior · Quantitative Biology 2014-09-23 Abhilash Nair , Brendon M. Baker , Britta Trappmann , Christopher S. Chen , Vivek B. Shenoy

Computer models of cardiac electro-mechanics (EM) show promise as an effective means for quantitative analysis of clinical data and, potentially, for predicting therapeutic responses.realize such advanced applications methodological key…

Embedding vector operations are a key component of modern deep neural network workloads. Unlike matrix operations with deterministic access patterns, embedding vector operations exhibit input data-dependent and non-deterministic memory…

Hardware Architecture · Computer Science 2025-11-11 Sangun Choi , Yunho Oh

Introduction: The extracellular matrix (ECM) is a networkof proteins and carbohydrates that has a structural and bio-chemical function. The ECM plays an important role in dif-ferentiation, migration and signaling. Several studies…

Quantitative Methods · Quantitative Biology 2022-02-17 Mohamed Ghafoor , Anh Nguyen

This project addresses the need for efficient, real-time analysis of biomedical signals such as electrocardiograms (ECG) and electroencephalograms (EEG) for continuous health monitoring. Traditional methods rely on long-duration data…

Signal Processing · Electrical Eng. & Systems 2025-04-22 Jinhai Hu

Cardiovascular disease affects millions of people worldwide and its social and economic cost clearly motivates scientific research. Computer simulation can lead to a better understanding of cardiac physiology, and for pathology presents…

Biological Physics · Physics 2023-02-27 Toby Simpson

Electrocardiogram (ECG) is a widely used tool for assessing cardiac function due to its low cost and accessibility. Emergent research shows that ECGs can help make predictions on key outcomes traditionally derived from more complex…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Chris McIntosh

The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…

Numerical Analysis · Mathematics 2025-11-03 Gopika P B , Peter Bastian , Nagaiah Chamakuri

High failure rates in cardiac drug development necessitate virtual clinical trials via electrocardiogram (ECG) generation to reduce risks and costs. However, existing ECG generation models struggle to balance morphological realism with…

Machine Learning · Computer Science 2026-03-31 Qian Shao , Bang Du , Zepeng Li , Qiyuan Chen , Jiahe Chen , Hongxia Xu , Jimeng Sun , Jian Wu , Jintai Chen

Simulating the cardiac function requires the numerical solution of multi-physics and multi-scale mathematical models. This underscores the need for streamlined, accurate, and high-performance computational tools. Despite the dedicated…

Autonomous robots in endovascular operations have the potential to navigate circulatory systems safely and reliably while decreasing the susceptibility to human errors. However, there are numerous challenges involved with the process of…

Cardiac biosignals, such as electrocardiograms (ECG) and photoplethysmograms (PPG), are of paramount importance for the diagnosis, prevention, and management of cardiovascular diseases, and have been extensively used in a variety of…

With the rapid advancement of metasurfaces and the increasing demand for programmable metasurfaces to simplify information systems, wave-based computation using metasurfaces has emerged as an attractive research topic. To facilitate the…

Computational models are increasingly used for diagnosis and treatment of cardiovascular disease. To provide a quantitative hemodynamic understanding that can be effectively used in the clinic, it is crucial to quantify the variability in…

Computational Engineering, Finance, and Science · Computer Science 2021-02-02 Xue Li , Daniele E. Schiavazzi

We present FabSim, a toolkit developed to simplify a range of computational tasks for researchers in diverse disciplines. FabSim is flexible, adaptable, and allows users to perform a wide range of tasks with ease. It also provides a…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-09-21 Derek Groen , Agastya Bhati , James Suter , James Hetherington , Stefan Zasada , Peter Coveney
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