English
Related papers

Related papers: M3ST-DTI: A multi-task learning model for drug-tar…

200 papers

Identification of drug-target interactions is an indispensable part of drug discovery. While conventional shallow machine learning and recent deep learning methods based on chemogenomic properties of drugs and target proteins have pushed…

Quantitative Methods · Quantitative Biology 2024-04-05 Yuanyuan Zhang , Yingdong Wang , Chaoyong Wu , Lingmin Zhana , Aoyi Wang , Caiping Cheng , Jinzhong Zhao , Wuxia Zhang , Jianxin Chen , Peng Li

Predicting the interaction between a compound and a target is crucial for rapid drug repurposing. Deep learning has been successfully applied in drug-target affinity (DTA) problem. However, previous deep learning-based methods ignore…

Machine Learning · Computer Science 2020-09-29 Tri Minh Nguyen , Thin Nguyen , Thao Minh Le , Truyen Tran

Drug-drug interaction (DDI) is a vital information when physicians and pharmacists intend to co-administer two or more drugs. Thus, several DDI databases are constructed to avoid mistakenly combined use. In recent years, automatically…

Computation and Language · Computer Science 2017-05-19 Zibo Yi , Shasha Li , Jie Yu , Qingbo Wu

Multiple object tracking (MOT) is a significant task in achieving autonomous driving. Traditional works attempt to complete this task, either based on point clouds (PC) collected by LiDAR, or based on images captured from cameras. However,…

Computer Vision and Pattern Recognition · Computer Science 2022-03-31 Guangming Wang , Chensheng Peng , Jinpeng Zhang , Hesheng Wang

This paper explores the development of a multimodal sentiment analysis model that integrates text, audio, and visual data to enhance sentiment classification. The goal is to improve emotion detection by capturing the complex interactions…

Computation and Language · Computer Science 2025-01-15 Hui Lee , Singh Suniljit , Yong Siang Ong

In online advertising, users may be exposed to a range of different advertising campaigns, such as natural search or referral or organic search, before leading to a final transaction. Estimating the contribution of advertising campaigns on…

Information Retrieval · Computer Science 2020-04-02 Dongdong Yang , Kevin Dyer , Senzhang Wang

End-to-end autonomous driving has witnessed remarkable progress. However, the extensive deployment of autonomous vehicles has yet to be realized, primarily due to 1) inefficient multi-modal environment perception: how to integrate data from…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Dongyang Xu , Haokun Li , Qingfan Wang , Ziying Song , Lei Chen , Hanming Deng

Multispectral oriented object detection faces challenges due to both inter-modal and intra-modal discrepancies. Recent studies often rely on transformer-based models to address these issues and achieve cross-modal fusion detection. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Minghang Zhou , Tianyu Li , Chaofan Qiao , Dongyu Xie , Guoqing Wang , Ningjuan Ruan , Lin Mei , Yang Yang

Drug-target interaction (DTI) prediction, which aims at predicting whether a drug will be bounded to a target, have received wide attention recently, with the goal to automate and accelerate the costly process of drug design. Most of the…

Biomolecules · Quantitative Biology 2023-06-27 Shengming Zhang , Yizhou Sun

Multimodal medical image fusion plays an instrumental role in several areas of medical image processing, particularly in disease recognition and tumor detection. Traditional fusion methods tend to process each modality independently before…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Lin Liu , Xinxin Fan , Chulong Zhang , Jingjing Dai , Yaoqin Xie , Xiaokun Liang

Assessing drug-target affinity is a critical step in the drug discovery and development process, but to obtain such data experimentally is both time consuming and expensive. For this reason, computational methods for predicting binding…

Machine Learning · Computer Science 2022-09-15 Elizaveta Vinogradova , Karina Pats , Ferdinand Molnár , Siamac Fazli

Multi-modal fusion methods often suffer from two types of representation collapse: feature collapse where individual dimensions lose their discriminative power (as measured by eigenspectra), and modality collapse where one dominant modality…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Seulgi Kim , Kiran Kokilepersaud , Mohit Prabhushankar , Ghassan AlRegib

In vivo cardiac diffusion tensor imaging (cDTI) is a promising Magnetic Resonance Imaging (MRI) technique for evaluating the micro-structure of myocardial tissue in the living heart, providing insights into cardiac function and enabling the…

Recent studies have shown that neural models can achieve high performance on several sequence labelling/tagging problems without the explicit use of linguistic features such as part-of-speech (POS) tags. These models are trained only using…

Machine Learning · Computer Science 2019-10-01 Isaac K. E. Ampomah , Sally McClean , Zhiwei Lin , Glenn Hawe

Early diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) utilizing multi-modal magnetic resonance imaging (MRI) is a pivotal area of research. While various regional and connectivity features from functional…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Xiongri Shen , Zhenxi Song , Linling Li , Min Zhang , Lingyan Liang Honghai Liu , Demao Deng , Zhiguo Zhang

We describe the accurate prediction of ligand-protein interaction (LPI) affinities, also known as drug-target interactions (DTI), with instruction fine-tuned pretrained generative small language models (SLMs). We achieved accurate…

Machine Learning · Computer Science 2024-07-02 Ben Fauber

Unsupervised domain adaptation object detection (UDAOD) research on Detection Transformer(DETR) mainly focuses on feature alignment and existing methods can be divided into two kinds, each of which has its unresolved issues. One-stage…

Computer Vision and Pattern Recognition · Computer Science 2024-01-19 Weixi Weng , Chun Yuan

Accurate extraction of molecular representations is a critical step in the drug discovery process. In recent years, significant progress has been made in molecular representation learning methods, among which multi-modal molecular…

Machine Learning · Computer Science 2025-05-13 Rong Yin , Ruyue Liu , Xiaoshuai Hao , Xingrui Zhou , Yong Liu , Can Ma , Weiping Wang

Drug-target binding affinity prediction plays an important role in the early stages of drug discovery, which can infer the strength of interactions between new drugs and new targets. However, the performance of previous computational models…

Machine Learning · Computer Science 2023-07-19 Xinxing Yang , Genke Yang , Jian Chu

Existing top-performance autonomous driving systems typically rely on the multi-modal fusion strategy for reliable scene understanding. This design is however fundamentally restricted due to overlooking the modality-specific strengths and…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Zeyu Yang , Nan Song , Wei Li , Xiatian Zhu , Li Zhang , Philip H. S. Torr