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Engineering problem solving is central to real-world decision-making, requiring mathematical formulations that not only represent complex problems but also produce feasible solutions under data and physical constraints. Unlike mathematical…

Artificial Intelligence · Computer Science 2026-05-05 Xiyuan Zhou , Ruixi Zou , Xinlei Wang , Yuheng Cheng , Yan Xu , Junhua Zhao , Jinjin Gu

Modern enterprise environments demand intelligent systems capable of handling complex, dynamic, and multi-faceted tasks with high levels of autonomy and adaptability. However, traditional single-purpose AI systems often lack sufficient…

Computation and Language · Computer Science 2025-08-26 Siyi Wu , Zeyu Wang , Xinyuan Song , Zhengpeng Zhou , Lifan Sun , Tianyu Shi

We introduce the concept of "Design Agents" for engineering applications, particularly focusing on the automotive design process, while emphasizing that our approach can be readily extended to other engineering and design domains. Our…

Artificial Intelligence · Computer Science 2025-12-04 Mohamed Elrefaie , Janet Qian , Raina Wu , Qian Chen , Angela Dai , Faez Ahmed

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Creating end-to-end bioinformatics workflows requires diverse domain expertise, which poses challenges for both junior and senior researchers as it demands a deep understanding of both genomics concepts and computational techniques. While…

Agent-based simulation is an indispensable paradigm for studying complex systems. These systems can comprise billions of agents, requiring the computing resources of multiple servers to simulate. Unfortunately, the state-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-30 Lukas Breitwieser , Ahmad Hesam , Abdullah Giray Yağlıkçı , Mohammad Sadrosadati , Fons Rademakers , Onur Mutlu

Background: Simulated patient systems are important in medical education and research, providing safe, integrative training environments and supporting clinical decision making. Advances in artificial intelligence (AI), especially large…

Agents built on large language models (LLMs) have excelled in turn-by-turn human-AI collaboration but struggle with simultaneous tasks requiring real-time interaction. Latency issues and the challenge of inferring variable human strategies…

Artificial Intelligence · Computer Science 2025-05-29 Shao Zhang , Xihuai Wang , Wenhao Zhang , Chaoran Li , Junru Song , Tingyu Li , Lin Qiu , Xuezhi Cao , Xunliang Cai , Wen Yao , Weinan Zhang , Xinbing Wang , Ying Wen

Agentic AI is rapidly advancing in healthcare and biomedical research. However, in medical image analysis, their performance and adoption remain limited due to the lack of a robust ecosystem, insufficient toolsets, and the absence of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Songhao Li , Jonathan Xu , Tiancheng Bao , Yuxuan Liu , Yuchen Liu , Yihang Liu , Lilin Wang , Wenhui Lei , Sheng Wang , Yinuo Xu , Yan Cui , Jialu Yao , Shunsuke Koga , Zhi Huang

Computational materials science and chemistry span vast knowledge domains and fractured software ecosystems. Although large language models (LLMs) have demonstrated research capabilities, scaling monolithic agents to manage the rigor and…

Recent studies have begun to explore proactive large language model (LLM) agents that provide unobtrusive assistance by automatically leveraging contextual information, such as in code editing and in-app suggestions. However, most focus on…

Artificial Intelligence · Computer Science 2026-05-08 Bufang Yang , Lilin Xu , Liekang Zeng , Yunqi Guo , Siyang Jiang , Wenrui Lu , Kaiwei Liu , Yixuan Li , Xiaofan Jiang , Guoliang Xing , Zhenyu Yan

Agents centered around Large Language Models (LLMs) are now capable of automating mobile device operations for users. After fine-tuning to learn a user's mobile operations, these agents can adhere to high-level user instructions online.…

Human-Computer Interaction · Computer Science 2024-01-18 Tinghe Ding

Atomistic simulations are essential tools in chemistry and materials science, accelerating the discovery of novel catalysts, energy storage materials, and pharmaceuticals. However, running these simulations remains challenging due to the…

Chemical Physics · Physics 2025-06-11 Thang D. Pham , Aditya Tanikanti , Murat Keçeli

Current tool-using AI agents suffer from limited action space, context inefficiency, and probabilistic instability that makes them unsuitable for handling repetitive tasks which are otherwise reliably and efficiently tackled by agentic…

Software Engineering · Computer Science 2025-12-19 Nishant Gaurav , Adit Akarsh , Tejas Ravishankar , Manoj Bajaj

Large language models have enabled agentic systems that reason, plan, and interact with tools and environments to accomplish complex tasks. As these agents operate over extended interaction horizons, their effectiveness increasingly depends…

Artificial Intelligence · Computer Science 2026-03-17 Yue Xu , Qian Chen , Zizhan Ma , Dongrui Liu , Wenxuan Wang , Xiting Wang , Li Xiong , Wenjie Wang

The deployment of Large Language Models (LLMs) in interactive systems necessitates a deep alignment with the nuanced and dynamic preferences of individual users. Current alignment techniques predominantly address universal human values or…

Computation and Language · Computer Science 2025-12-18 Xiaotian Zhang , Yuan Wang , Ruizhe Chen , Zeya Wang , Runchen Hou , Zuozhu Liu

Recent advancements in AI-driven conversational agents have exhibited immense potential of AI applications. Effective response generation is crucial to the success of these agents. While extensive research has focused on leveraging multiple…

Computation and Language · Computer Science 2025-03-26 Junfeng Liu , Christopher T. Symons , Ranga Raju Vatsavai

As large language models (LLMs) evolve into sophisticated autonomous agents capable of complex software development tasks, evaluating their real-world capabilities becomes critical. While existing benchmarks like…

Agentic systems, AI architectures that autonomously execute multi-step workflows to achieve complex goals, are often built using repeated large language model (LLM) calls for closed-set decision tasks such as routing, shortlisting, gating,…

Computation and Language · Computer Science 2026-02-19 Ido Levy , Eilam Shapira , Yinon Goldshtein , Avi Yaeli , Nir Mashkif , Segev Shlomov