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The "reproducibility crisis" has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the…

Computers and Society · Computer Science 2018-04-24 Gopal P. Sarma

The presence of second-order smoothness for objective functions of optimization problems can provide valuable information about their stability properties and help us design efficient numerical algorithms for solving these problems. Such…

Optimization and Control · Mathematics 2023-08-04 N. T. V. Hang , M. E. Sarabi

The two-trials rule for drug approval requires "at least two adequate and well-controlled studies, each convincing on its own, to establish effectiveness". This is usually implemented by requiring two significant pivotal trials and is the…

Methodology · Statistics 2023-11-10 Leonhard Held

Chen and Cheng [Ann. Statist. 34 (2006) 546--558] discussed the method of doubling for constructing two-level fractional factorial designs. They showed that for $9N/32\le n\le 5N/16$, all minimum aberration designs with $N$ runs and $n$…

Statistics Theory · Mathematics 2008-12-18 Hongquan Xu , Ching-Shui Cheng

While extensive guidance exists for ensuring the reproducibility of one's own study, there is little discussion regarding the reproduction and replication of external studies within one's own research. To initiate this discussion, drawing…

Machine Learning · Computer Science 2024-01-10 Milton S. Gomez , Tom Beucler

When the co-recursion and co-dilation in the recurrence relation of certain sequences of orthogonal polynomials are not at the same level, the behaviour of the modified orthogonal polynomials is expected to have different properties…

Classical Analysis and ODEs · Mathematics 2024-05-14 Vinay Shukla , A. Swaminathan

This paper deals with the problem of evaluating the causal effect using observational data in the presence of an unobserved exposure/ outcome variable, when cause-effect relationships between variables can be described as a directed acyclic…

Methodology · Statistics 2012-06-18 Manabu Kuroki , Zhihong Cai

For every pattern $p$ over the alphabet $\{x,y,x^R,y^R\}$, we specify the least $k$ such that $p$ is $k$-avoidable.

Combinatorics · Mathematics 2015-08-24 James D. Currie , Philip Lafrance

Causal reversibility blends reversibility and causality for concurrent systems. It indicates that an action can be undone provided that all of its consequences have been undone already, thus making it possible to bring the system back to a…

Logic in Computer Science · Computer Science 2024-02-14 Marco Bernardo , Claudio A. Mezzina

Unreplicated two-level factorial designs are often used in screening experiments to determine which factors out of a large plausible set are active. A theorem regarding the generalized word count pattern is stated and proved for…

Methodology · Statistics 2025-10-14 Xietao Zhou , Steven G. Gilmour

The doubly-robust (DR) estimator is popular for evaluating causal effects in observational studies and is often perceived as more desirable than inverse probability weighting (IPW) or outcome modeling alone because it provides extra…

Methodology · Statistics 2026-02-03 Chengxin Yang , Laine E. Thomas , Fan Li

Suppose we are interested in the effect of variable $X$ on variable $Y$. If $X$ and $Y$ both influence, or are associated with variables that influence, a common outcome, called a collider, then conditioning on the collider (or on a…

Methodology · Statistics 2020-02-13 Trang Quynh Nguyen , Allan Dafoe , Elizabeth L. Ogburn

In the past two decades, psychological science has experienced an unprecedented replicability crisis which uncovered several issues. Among others, statistical inference is too often viewed as an isolated procedure limited to the analysis of…

The paper provides a simple test for deciding, from a given causal diagram, whether two sets of variables have the same bias-reducing potential under adjustment. The test requires that one of the following two conditions holds: either (1)…

Methodology · Statistics 2012-03-19 Judea Pearl , Azaria Paz

It is time to renew old ways of thinking about dimensional analysis. Specifically, more than $n-r$ invariants and more than one functional relation between invariants need to be considered simultaneously. Thus generalized, dimensional…

History and Overview · Mathematics 2014-11-12 Dan Jonsson

We consider the following novel variation on a classical avoidance problem from combinatorics on words: instead of avoiding repetitions in all factors of a word, we avoid repetitions in all factors where each individual factor is considered…

Formal Languages and Automata Theory · Computer Science 2013-03-19 Hamoon Mousavi , Jeffrey Shallit

In this paper, the problem of error control of stepwise multiple testing procedures is considered. For two-sided hypotheses, control of both type 1 and type 3 (or directional) errors is required, and thus mixed directional familywise error…

Statistics Theory · Mathematics 2016-02-10 Wenge Guo , Joseph P. Romano

The two-sample problem, which consists in testing whether independent samples on $\mathbb{R}^d$ are drawn from the same (unknown) distribution, finds applications in many areas. Its study in high-dimension is the subject of much attention,…

Statistics Theory · Mathematics 2023-02-09 Stephan Clémençon , Myrto Limnios , Nicolas Vayatis

In the field of road safety, it is common to use responsibility analyses to assess the effect of a given factor on the risk of being responsible for an accident, among drivers involved in an accident only. Even if this design is now widely…

Methodology · Statistics 2018-10-16 Marine Dufournet , Emilie Lanoy , Jean-Louis Martin , Vivian Viallon

We initiate a systematic investigation of distribution testing in the framework of algorithmic replicability. Specifically, given independent samples from a collection of probability distributions, the goal is to characterize the sample…

Machine Learning · Computer Science 2025-07-04 Ilias Diakonikolas , Jingyi Gao , Daniel Kane , Sihan Liu , Christopher Ye