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Missing modality issues are common in real-world applications, arising from factors such as equipment failures and privacy concerns. When fine-tuning pre-trained models on downstream datasets with missing modalities, performance can degrade…

Machine Learning · Computer Science 2025-03-04 Zirun Guo , Shulei Wang , Wang Lin , Weicai Yan , Yangyang Wu , Tao Jin

Synthesizing missing modalities in multi-modal magnetic resonance imaging (MRI) is vital for ensuring diagnostic completeness, particularly when full acquisitions are infeasible due to time constraints, motion artifacts, and patient…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Yue Zhang , Zhizheng Zhuo , Siyao Xu , Shan Lv , Zhaoxi Liu , Jun Qiu , Qiuli Wang , Yaou Liu , S. Kevin Zhou

An active challenge in developing multimodal machine learning (ML) models for healthcare is handling missing modalities during training and deployment. As clinical datasets are inherently temporal and sparse in terms of modality presence,…

Machine Learning · Computer Science 2026-05-08 Andrew Wang , Ellie Pavlick , Ritambhara Singh

The use of diverse modalities, such as omics, medical images, and clinical data can not only improve the performance of prognostic models but also deepen an understanding of disease mechanisms and facilitate the development of novel…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Maria Boyko , Aleksandra Beliaeva , Dmitriy Kornilov , Alexander Bernstein , Maxim Sharaev

Multimodal data collected from the real world are often imperfect due to missing modalities. Therefore multimodal models that are robust against modal-incomplete data are highly preferred. Recently, Transformer models have shown great…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Mengmeng Ma , Jian Ren , Long Zhao , Davide Testuggine , Xi Peng

Multimodal clinical records contain structured measurements and clinical notes recorded over time, offering rich temporal information about the evolution of patient health. Yet these observations are sparse, and whether they are recorded…

Machine Learning · Computer Science 2026-04-24 Zihan Liang , Ziwen Pan , Ruoxuan Xiong

Many healthcare sensing applications utilize multimodal time-series data from sensors embedded in mobile and wearable devices. Federated Learning (FL), with its privacy-preserving advantages, is particularly well-suited for health…

Machine Learning · Computer Science 2024-11-28 Adiba Orzikulova , Jaehyun Kwak , Jaemin Shin , Sung-Ju Lee

Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete…

Machine Learning · Computer Science 2026-05-13 Camillo Maria Caruso , Valerio Guarrasi , Paolo Soda

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Xiaogen Zhou , Yiyou Sun , Min Deng , Winnie Chiu Wing Chu , Qi Dou

Multi-modal learning has made significant advances across diverse pattern recognition applications. However, handling missing modalities, especially under imbalanced missing rates, remains a major challenge. This imbalance triggers a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Binyu Zhao , Wei Zhang , Zhaonian Zou

Multimodal deep learning systems which employ multiple modalities like text, image, audio, video, etc., are showing better performance in comparison with individual modalities (i.e., unimodal) systems. Multimodal machine learning involves…

Machine Learning · Computer Science 2022-01-19 Anil Rahate , Rahee Walambe , Sheela Ramanna , Ketan Kotecha

Combining multiple modalities carrying complementary information through multimodal learning (MML) has shown considerable benefits for diagnosing multiple pathologies. However, the robustness of multimodal models to missing modalities is…

Machine Learning · Computer Science 2024-07-31 Hava Chaptoukaev , Vincenzo Marcianó , Francesco Galati , Maria A. Zuluaga

Multimodal physiological data powers clinical AI systems from intensive care units to wearable devices, but sensors routinely fail in practice. Two failure modes are common: modality missing, where an entire channel is absent, and…

Machine Learning · Computer Science 2026-05-18 Wugeng Zheng , Ziwen Kan , Tianlong Chen , Chen Chen , Song Wang

Recently, multimodal prompting, which introduces learnable missing-aware prompts for all missing modality cases, has exhibited impressive performance. However, it encounters two critical issues: 1) The number of prompts grows exponentially…

Computer Vision and Pattern Recognition · Computer Science 2023-12-29 Jaehyuk Jang , Yooseung Wang , Changick Kim

Multimodal learning has demonstrated remarkable performance improvements over unimodal architectures. However, multimodal learning methods often exhibit deteriorated performances if one or more modalities are missing. This may be attributed…

Multimodal learning has demonstrated incredible successes by integrating diverse data sources, yet it often relies on the availability of all modalities - an assumption that rarely holds in real-world applications. Pretrained multimodal…

Machine Learning · Computer Science 2025-04-21 Duy A. Nguyen , Quan Huu Do , Khoa D. Doan , Minh N. Do

Multi-modal medical images provide complementary soft-tissue characteristics that aid in the screening and diagnosis of diseases. However, limited scanning time, image corruption and various imaging protocols often result in incomplete…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Yue Zhang , Chengtao Peng , Qiuli Wang , Dan Song , Kaiyan Li , S. Kevin Zhou

Multimodal models integrating natural language and visual information have substantially improved generalization of representation models. However, their effectiveness significantly declines in real-world situations where certain modalities…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Jiajun Chen , Sai Cheng , Yutao Yuan , Yirui Zhang , Haitao Yuan , Peng Peng , Yi Zhong

The missing modality problem poses a fundamental challenge in multimodal sentiment analysis, significantly degrading model accuracy and generalization in real world scenarios. Existing approaches primarily improve robustness through prompt…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Rongfei Chen , Tingting Zhang , Xiaoyu Shen , Wei Zhang

Multimodal sentiment analysis relies on textual, acoustic, and visual signals, yet real-world data often suffer from modality missing and quality imbalance. Existing methods generate features for modality missing from available ones, but…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Chenglizhao Chen , Yuchen Cao , Xinyu Liu , Mengke Song , Guisheng Zhang , Xiaomin Yu