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The metabolism of an organism is regulated at the cellular level, yet is strongly influenced by its environment. The precise metabolomic study of living organisms is currently hampered by measurement sensitivity: most metabolomic…

Quantitative Methods · Quantitative Biology 2017-07-28 Jan G. Korvink , Vlad Badilita , Lorenzo Bordonali , Mazin Jouda , Dario Mager , Neil MacKinnon

Statistical shape modeling (SSM) directly from 3D medical images is an underutilized tool for detecting pathology, diagnosing disease, and conducting population-level morphology analysis. Deep learning frameworks have increased the…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Jadie Adams , Shireen Elhabian

Extracting quantitative phenotypic information from whole-slide images presents significant challenges for investigators who are not experienced in developing image analysis algorithms. We present new software that enables rapid…

Mass spectrometry (MS) is used widely in biomolecular structural analysis and is particularly dominant in the study of proteins. Despite its considerable power, state-of-the-art protein MS frequently suffers from limited reliability of…

Accurate prediction of molecular metabolic stability (MS) is critical for drug research and development but remains challenging due to the complex interplay of molecular interactions. Despite recent advances in graph neural networks (GNNs)…

Machine Learning · Computer Science 2025-06-03 Peijin Guo , Minghui Li , Hewen Pan , Bowen Chen , Yang Wu , Zikang Guo , Leo Yu Zhang , Shengshan Hu , Shengqing Hu

Swift and accurate blood smear analysis is an effective diagnostic method for leukemia and other hematological malignancies. However, manual leukocyte count and morphological evaluation using a microscope is time-consuming and prone to…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Chandravardhan Singh Raghaw , Arnav Sharma , Shubhi Bansal , Mohammad Zia Ur Rehman , Nagendra Kumar

Robotic ultrasound (US) systems have shown great potential to make US examinations easier and more accurate. Recently, various machine learning techniques have been proposed to realize automatic US image interpretation for robotic US…

Robotics · Computer Science 2023-05-17 Keyu Li , Xinyu Mao , Chengwei Ye , Ang Li , Yangxin Xu , Max Q. -H. Meng

Small-molecule identification from tandem mass spectrometry (MS/MS) remains a bottleneck in untargeted settings where spectral libraries are incomplete. While deep learning offers a solution, current approaches typically fall into two…

Machine Learning · Computer Science 2026-03-05 Yinkai Wang , Yan Zhou Chen , Xiaohui Chen , Li-Ping Liu , Soha Hassoun

Identifying a small molecule from its mass spectrum is the primary open problem in computational metabolomics. This is typically cast as information retrieval: an unknown spectrum is matched against spectra predicted computationally from a…

Machine Learning · Computer Science 2023-01-30 Michael Murphy , Stefanie Jegelka , Ernest Fraenkel , Tobias Kind , David Healey , Thomas Butler

Magnetic resonance spectroscopy (MRS) is used to quantify metabolites in vivo and estimate biomarkers for conditions ranging from neurological disorders to cancers. Quantifying low-concentration metabolites such as GABA…

Signal Processing · Electrical Eng. & Systems 2026-02-25 Zien Ma , S. M. Shermer , Oktay Karakuş , Frank C. Langbein

Medical image segmentation plays a pivotal role in disease diagnosis and treatment planning, particularly in resource-constrained clinical settings where lightweight and generalizable models are urgently needed. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Chengqi Dong , Fenghe Tang , Rongge Mao , Xinpei Gao , S. Kevin Zhou

Molecular dynamics (MD) simulations have become indispensable for exploring tribological deformation patterns at the atomic scale. However, transforming the resulting high-dimensional data into interpretable deformation pattern maps remains…

Materials Science · Physics 2025-12-08 Hendrik J. Ehrich , Marvin C. May , Stefan J. Eder

Cross-domain Few-shot Medical Image Segmentation (CD-FSMIS) is a potential solution for segmenting medical images with limited annotation using knowledge from other domains. The significant performance of current CD-FSMIS models relies on…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Yazhou Zhu , Haofeng Zhang

Dual-energy computed tomography (DECT) utilizes separate X-ray energy spectra to improve multi-material decomposition (MMD) for various diagnostic applications. However accurate decomposing more than two types of material remains…

Image and Video Processing · Electrical Eng. & Systems 2023-11-02 Di Xu , Qihui Lyu , Dan Ruan , Ke Sheng

Tabular data have been extensively used in different knowledge domains. Convolutional neural networks (CNNs) have been successfully used in many applications where important information about data is embedded in the order of features…

Computer Vision and Pattern Recognition · Computer Science 2024-06-24 Vanesa Gómez-Martínez , Francisco J. Lara-Abelenda , Pablo Peiro-Corbacho , David Chushig-Muzo , Conceicao Granja , Cristina Soguero-Ruiz

Mass spectrometry-based metabolomics generates complex, high-dimensional data that holds vast potential for biological discovery but remains difficult to integrate and interpret. Knowledge graphs (KGs) unify this heterogeneous information…

Source camera model identification (CMI) and image manipulation detection are of paramount importance in image forensics. In this paper, we propose an L2-constrained Remnant Convolutional Neural Network (L2-constrained RemNet) for…

Image and Video Processing · Electrical Eng. & Systems 2020-09-15 Abdul Muntakim Rafi , Jonathan Wu , Md. Kamrul Hasan

Recent advances in multi-modal AI have demonstrated promising potential for generating the currently expensive spatial transcriptomics (ST) data directly from routine histology images, offering a means to reduce the high cost and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Junchao Zhu , Ruining Deng , Junlin Guo , Tianyuan Yao , Juming Xiong , Chongyu Qu , Mengmeng Yin , Yu Wang , Shilin Zhao , Haichun Yang , Daguang Xu , Yucheng Tang , Yuankai Huo

Accurate medical image segmentation allows for the precise delineation of anatomical structures and pathological regions, which is essential for treatment planning, surgical navigation, and disease monitoring. Both CNN-based and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Libin Lan , Yanxin Li , Xiaojuan Liu , Juan Zhou , Jianxun Zhang , Nannan Huang , Yudong Zhang

Despite recent progress on semantic segmentation, there still exist huge challenges in medical ultra-resolution image segmentation. The methods based on multi-branch structure can make a good balance between computational burdens and…

Computer Vision and Pattern Recognition · Computer Science 2020-02-20 Tong Wu , Yuan Xie , Yanyun Qu , Bicheng Dai , Shuxin Chen
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