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Timely identification and accurate risk stratification of cardiovascular disease (CVD) remain essential for reducing global mortality. While existing prediction models primarily leverage structured data, unstructured clinical notes contain…

Computation and Language · Computer Science 2025-07-16 Haowei Yang , Ziyu Shen , Junli Shao , Luyao Men , Xinyue Han , Jing Dong

Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited. This is likely due to their insufficient exposure to…

Tuberculosis (TB) is the leading cause of death from an infectious disease globally, with the highest burden in low- and middle-income countries. In these regions, limited healthcare access and high patient-to-provider ratios impede…

Artificial Intelligence · Computer Science 2025-03-03 Daniil Filienko , Mahek Nizar , Javier Roberti , Denise Galdamez , Haroon Jakher , Sarah Iribarren , Weichao Yuwen , Martine De Cock

While large language models (LLMs) have demonstrated impressive capabilities across various natural language processing tasks by acquiring rich factual knowledge from their broad training data, their ability to synthesize and logically…

Computation and Language · Computer Science 2024-07-31 Tianshi Zheng , Jiaxin Bai , Yicheng Wang , Tianqing Fang , Yue Guo , Yauwai Yim , Yangqiu Song

Despite the large number of patients in Electronic Health Records (EHRs), the subset of usable data for modeling outcomes of specific phenotypes are often imbalanced and of modest size. This can be attributed to the uneven coverage of…

Machine Learning · Computer Science 2021-03-25 Mohamed Ghalwash , Zijun Yao , Prithwish Chakraborty , James Codella , Daby Sow

Rare diseases present unique challenges in healthcare, often suffering from delayed diagnosis and fragmented information landscapes. The scarcity of reliable knowledge in these conditions poses a distinct challenge for Large Language Models…

Computation and Language · Computer Science 2024-11-06 Karthik Soman , Andrew Langdon , Catalina Villouta , Chinmay Agrawal , Lashaw Salta , Braian Peetoom , Gianmarco Bellucci , Orion J Buske

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as…

Machine Learning · Computer Science 2024-04-11 Hongru Du , Jianan Zhao , Yang Zhao , Shaochong Xu , Xihong Lin , Yiran Chen , Lauren M. Gardner , Hao Frank Yang

Clinical text is rich in information, with mentions of treatment, medication and anatomy among many other clinical terms. Multiple terms can refer to the same core concepts which can be referred as a clinical entity. Ontologies like the…

Computation and Language · Computer Science 2024-05-28 Akshit Achara , Sanand Sasidharan , Gagan N

Retrieval-augmented learning based on radiology reports has emerged as a promising direction to improve performance on long-tail medical imaging tasks, such as rare disease detection in chest X-rays. Most existing methods rely on comparing…

Machine Learning · Computer Science 2025-08-28 Felix Nützel , Mischa Dombrowski , Bernhard Kainz

Training large language models (LLMs) with synthetic reasoning data has become a popular approach to enhancing their reasoning capabilities, while a key factor influencing the effectiveness of this paradigm is the quality of the generated…

Artificial Intelligence · Computer Science 2026-03-24 Zhuojie Yang , Wentao Wan , Keze Wang

This paper addresses the challenges posed by the unstructured nature and high-dimensional semantic complexity of electronic health record texts. A deep learning method based on attention mechanisms is proposed to achieve unified modeling…

Computation and Language · Computer Science 2025-07-03 Ting Xu , Xiaoxiao Deng , Xiandong Meng , Haifeng Yang , Yan Wu

By adequate employing of complex event processing (CEP), valuable information can be extracted from the underlying complex system and used in controlling and decision situations. An example application area is management of IT systems for…

Software Engineering · Computer Science 2012-08-02 Istvan David

This paper explores the integration of Large Language Models (LLMs) in the engineering of a Parkinson's Disease (PD) monitoring and alerting ontology through four key methodologies: One Shot (OS) prompt techniques, Chain of Thought (CoT)…

Artificial Intelligence · Computer Science 2025-12-17 Georgios Bouchouras , Dimitrios Doumanas , Andreas Soularidis , Konstantinos Kotis , George A. Vouros

Recent advancements in reasoning-enhanced large language models (LLMs), such as DeepSeek-R1 and OpenAI-o3, have demonstrated significant progress. However, their application in professional medical contexts remains underexplored,…

Computation and Language · Computer Science 2025-03-11 Pengcheng Qiu , Chaoyi Wu , Shuyu Liu , Weike Zhao , Zhuoxia Chen , Hongfei Gu , Chuanjin Peng , Ya Zhang , Yanfeng Wang , Weidi Xie

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

Large language models (LLMs) have recently demonstrated impressive multimodal reasoning capabilities, yet their understanding of purely numerical time-series signals remains limited. Existing approaches mainly focus on forecasting or trend…

Machine Learning · Computer Science 2025-10-29 Ninghui Feng , Yiyan Qi

Large-scale tuberculosis (TB) screening is limited by the high cost and operational complexity of traditional diagnostics, creating a need for artificial-intelligence solutions. We propose DeepGB-TB, a non-invasive system that instantly…

Machine Learning · Computer Science 2026-02-03 Zhixiang Lu , Yulong Li , Feilong Tang , Zhengyong Jiang , Chong Li , Mian Zhou , Tenglong Li , Jionglong Su

Large language models (LLMs) have shown great potential in the medical domain. However, existing models still fall short when faced with complex medical diagnosis task in the real world. This is mainly because they lack sufficient reasoning…

Artificial Intelligence · Computer Science 2025-08-06 Qi Peng , Jialin Cui , Jiayuan Xie , Yi Cai , Qing Li

Research projects, including those focused on cancer, rely on the manual extraction of information from clinical reports. This process is time-consuming and prone to errors, limiting the efficiency of data-driven approaches in healthcare.…

Computation and Language · Computer Science 2025-05-16 J. Moreno-Casanova , J. M. Auñón , A. Mártinez-Pérez , M. E. Pérez-Martínez , M. E. Gas-López

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng
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