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Image-based or morphological profiling is a rapidly expanding field wherein cells are "profiled" by extracting hundreds to thousands of unbiased, quantitative features from images of cells that have been perturbed by genetic or chemical…

Quantitative Methods · Quantitative Biology 2024-11-07 Erin Weisbart , Ankur Kumar , John Arevalo , Anne E. Carpenter , Beth A. Cimini , Shantanu Singh

The problem of cell association is considered for cellular users present in the field. This has become a challenging problem with the deployment of 5G networks which will share the sub-6 GHz bands with the legacy 4G networks. Instead of…

Signal Processing · Electrical Eng. & Systems 2019-10-31 Yinsong Wang , Hessam Mahdavifar , Kamran Entesari , Shahin Shahrampour

The cell cycle duration is a variable cellular phenotype that underlies long-term population growth and age structures. By analyzing the stationary solutions of a branching process with heritable cell division times, we demonstrate…

Populations and Evolution · Quantitative Biology 2021-01-04 Takashi Nozoe , Edo Kussell

The recent advances in single-cell technologies have enabled us to profile genomic features at unprecedented resolution and datasets from multiple domains are available, including datasets that profile different types of genomic features…

Machine Learning · Statistics 2020-06-09 Pengcheng Zeng , Zhixiang Lin

Understanding the higher-order interactions within network data is a key objective of network science. Surveys of metadata triangles (or patterned 3-cycles in metadata-enriched graphs) are often of interest in this pursuit. In this work, we…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-07-27 Trevor Steil , Tahsin Reza , Keita Iwabuchi , Benjamin W. Priest , Geoffrey Sanders , Roger Pearce

Our work targets automated analysis to quantify the growth dynamics of a population of bacilliform bacteria. We propose an innovative approach to frame-sequence tracking of deformable-cell motion by the automated minimization of a new,…

Computer Vision and Pattern Recognition · Computer Science 2022-07-12 Sorena Sarmadi , James J. Winkle , Razan N. Alnahhas , Matthew R. Bennett , Krešimir Josić , Andreas Mang , Robert Azencott

Coarse-graining microscopic models of biological neural networks to obtain mesoscopic models of neural activities is an essential step towards multi-scale models of the brain. Here, we extend a recent theory for mesoscopic population…

Neurons and Cognition · Quantitative Biology 2018-12-27 Valentin Schmutz , Wulfram Gerstner , Tilo Schwalger

For the Bio+Med-Vis Challenge 2024, we propose a visual analytics system as a redesign for the scatter pie chart visualization of cell type proportions of spatial transcriptomics data. Our design uses three linked views: a view of the…

Human-Computer Interaction · Computer Science 2024-09-12 David Hägele , Yuxuan Tang , Daniel Weiskopf

We have produced a new software package for the simulation of pulsar populations, \textsc{PsrPopPy}, based on the \textsc{Psrpop} package. The codebase has been re-written in Python (save for some external libraries, which remain in their…

Instrumentation and Methods for Astrophysics · Physics 2015-06-17 Sam Bates , Duncan Lorimer , Akshaya Rane , Joe Swiggum

Neighborhood graphs and clustering algorithms are fundamental structures in both computational geometry and data analysis. Visualizing them can help build insight into their behavior and properties. The Ipe extensible drawing editor,…

Living organisms rely on endogenous feedback mechanisms to maintain homeostasis in the presence of uncertainty and environmental fluctuations. An emerging challenge at the interface of control systems engineering and synthetic biology is…

Systems and Control · Electrical Eng. & Systems 2026-02-24 Mario di Bernardo

Systems biology is an inter-disciplinary field that studies systems of biological components at different scales, which may be molecules, cells or entire organism. In particular, systems biology methods are applied to understand functional…

Computational Engineering, Finance, and Science · Computer Science 2014-12-22 Thomas Cokelaer , Julio Saez-Rodriguez

The unrelenting increase in the population of mobile users and their traffic demands drive cellular network operators to densify their network infrastructure. Network densification shrinks the footprint of base stations (BSs) and reduces…

Information Theory · Computer Science 2016-07-22 Hazem Ibrahim , Hesham ElSawy , Uyen T. Nguyen , Mohamed-Slim Alouini

Results: We present an application that enables the quantitative analysis of multichannel 5-D (x, y, z, t, channel) and large montage confocal fluorescence microscopy images. The image sequences show stem cells together with blood vessels,…

Cataloging the neuronal cell types that comprise circuitry of individual brain regions is a major goal of modern neuroscience and the BRAIN initiative. Single-cell RNA sequencing can now be used to measure the gene expression profiles of…

Graph clustering has many important applications in computing, but due to the increasing sizes of graphs, even traditionally fast clustering methods can be computationally expensive for real-world graphs of interest. Scalability problems…

Social and Information Networks · Computer Science 2018-10-18 Kimon Fountoulakis , David F. Gleich , Michael W. Mahoney

Modelling, analysing and inferring triggering mechanisms in population reproduction is fundamental in many biological applications. It is also an active and growing research domain in mathematical biology. In this chapter, we review the…

Analysis of PDEs · Mathematics 2023-01-09 Marie Doumic , Marc Hoffmann

We present an application, Superplot, for calculating and plotting statistical quantities relevant to parameter inference from a "chain" of samples drawn from a parameter space, produced by e.g. MultiNest. A simple graphical interface…

Data Analysis, Statistics and Probability · Physics 2016-12-06 Andrew Fowlie , Michael Hugh Bardsley

The CellxGene project has enabled access to single-cell data in the scientific community, providing tools for browsed-based no-code analysis of more than 500 annotated datasets. However, single-cell data requires dimensional reduction to…

Human-Computer Interaction · Computer Science 2022-12-02 Luke Hyman , Ivo F. Sbalzarini , Stephen Quake , Ulrik Günther

We introduce a novel method for overlaying cell type proportion data onto tissue images. This approach preserves spatial context while avoiding visual clutter or excessively obscuring the underlying slide. Our proposed technique involves…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Lee Mason , Jonas Almeida
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