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Digital twins, as precise digital representations of physical systems, have evolved from passive simulation tools into intelligent and autonomous entities through the integration of artificial intelligence technologies. This paper presents…

Cardiac digital twins are computational tools capturing key functional and anatomical characteristics of patient hearts for investigating disease phenotypes and predicting responses to therapy. When paired with large-scale computational…

Computational Engineering, Finance, and Science · Computer Science 2024-01-19 Julia Camps , Zhinuo Jenny Wang , Ruben Doste , Maxx Holmes , Brodie Lawson , Jakub Tomek , Kevin Burrage , Alfonso Bueno-Orovio , Blanca Rodriguez

Understanding user identity and behavior is central to applications such as personalization, recommendation, and decision support. Most existing approaches rely on deterministic embeddings or black-box predictive models, offering limited…

Machine Learning · Computer Science 2025-12-23 Daniel David

Optimizing modern wireless networks is exceptionally challenging due to their high dynamism and complexity. While the agentic artificial intelligence (AI) powered by reinforcement learning (RL) offers a promising solution, its practical…

Systems and Control · Electrical Eng. & Systems 2025-11-26 Zhenyu Tao , Wei Xu , Xiaohu You

Proprietary workflow modeling languages such as Smart Forms & Smart Flow hamper interoperability and reuse because they lock process knowledge into closed formats. To address this vendor lock-in and ease migration to open standards, we…

Software Engineering · Computer Science 2025-11-18 Francisco Abreu , Luís Cruz , Sérgio Guerreiro

Despite the growing popularity of digital twin (DT) developments, there is a lack of common understanding and definition for important concepts of DT. It is needed to address this gap by building a shared understanding of DT before it…

Software Engineering · Computer Science 2023-12-08 Zhengyu Liu , Sina Namaki Araghi , Arkopaul Sarkar , Mohamed Hedi Karray

Digital twins (DT) are often defined as a pairing of a physical entity and a corresponding virtual entity (VE), mimicking certain aspects of the former depending on the use-case. In recent years, this concept has facilitated numerous…

Secure and interoperable integration of heterogeneous medical data remains a grand challenge in digital health. Current federated learning (FL) frameworks offer privacy-preserving model training but lack standardized mechanisms to…

Cryptography and Security · Computer Science 2025-10-03 Aueaphum Aueawatthanaphisut

Recently, there has been a growing interest in Multimodal Large Language Models (MLLMs) due to their remarkable potential in various tasks integrating different modalities, such as image and text, as well as applications such as image…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Jihen Amara , Birgitta König-Ries , Sheeba Samuel

This chapter describes a semantic dialogue system for radiologists in a comprehensive case study within the large-scale MEDICO project. MEDICO addresses the need for advanced semantic technologies in the search for medical image and patient…

Human-Computer Interaction · Computer Science 2017-01-26 Daniel Sonntag , Martin Huber , Manuel Möller , Alassane Ndiaye , Sonja Zillner , Alexander Cavallaro

The development of Digital Twins (DTs) represents a transformative advance for simulating and optimizing complex systems in a controlled digital space. Despite their potential, the challenge of constructing DTs that accurately replicate and…

Systems and Control · Electrical Eng. & Systems 2024-06-21 Longfei Ma , Nan Cheng , Xiucheng Wang , Jiong Chen , Yinjun Gao , Dongxiao Zhang , Jun-Jie Zhang

In modern healthcare, addressing the complexities of accurate disease prediction and personalized recommendations is both crucial and challenging. This research introduces MLtoGAI, which integrates Semantic Web technology with Machine…

Artificial Intelligence · Computer Science 2024-07-31 Shyam Dongre , Ritesh Chandra , Sonali Agarwal

There has been much progress in data-driven artificial intelligence technology for medical image analysis in the last decades. However, it still remains challenging due to its distinctive complexity of acquiring and annotating image data,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Chao Gou , Tianyu Shen , Wenbo Zheng , Huadan Xue , Hui Yu , Qiang Ji , Zhengyu Jin , Fei-Yue Wang

Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to…

Digital Twin (DT) technology is far from being comprehensive and mature, resulting in their piecemeal implementation in practice where some functions are automated by DTs, and others are still performed by humans. This piecemeal…

Human-Computer Interaction · Computer Science 2023-01-10 Ashwin Agrawal , Robert Thiel , Pooja Jain , Vishal Singh , Martin Fischer

Digital twin technology is a transformative innovation driving the digital transformation and intelligent optimization of manufacturing systems. By integrating real-time data with computational models, digital twins enable continuous…

Emerging Technologies · Computer Science 2025-03-05 Linyao Yang , Shi Luo , Xi Cheng , Lei Yu

The Internet of things (IoT) can significantly enhance the quality of human life, specifically in healthcare, attracting extensive attentions to IoT-healthcare services. Meanwhile, the human digital twin (HDT) is proposed as an innovative…

Human-Computer Interaction · Computer Science 2024-07-01 Jiayuan Chen , You Shi , Changyan Yi , Hongyang Du , Jiawen Kang , Dusit Niyato

Large language models (LLMs) are used as "digital twins" to replace human respondents, yet their psychometric comparability to humans is uncertain. We propose a construct-validity framework spanning construct representation and the…

Computers and Society · Computer Science 2026-01-23 Yufei Zhang , Zhihao Ma

The inherent multimodality and heterogeneous temporal structures of medical data pose significant challenges for modeling. We propose MedM2T, a time-aware multimodal framework designed to address these complexities. MedM2T integrates: (i)…

Machine Learning · Computer Science 2026-03-26 Yu-Chen Kuo , Yi-Ju Tseng

Duplicate records pose significant challenges in customer relationship management (CRM)and healthcare, often leading to inaccuracies in analytics, impaired user experiences, and compliance risks. Traditional deduplication methods rely…

Machine Learning · Computer Science 2026-03-27 Mohammed Omer Shakeel Ahmed