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Musculoskeletal disorders (MSDs) are a leading cause of disability worldwide, requiring advanced diagnostic and therapeutic tools for personalised assessment and treatment. Effective management of MSDs involves the interaction of…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Martina Paccini , Simone Cammarasana , Giuseppe Patanè

Digital Twins (DT) are essentially dynamic data-driven models that serve as real-time symbiotic "virtual replicas" of real-world systems. DT can leverage fundamentals of Dynamic Data-Driven Applications Systems (DDDAS) bidirectional…

Artificial Intelligence · Computer Science 2024-02-01 Nan Zhang , Rami Bahsoon , Nikos Tziritas , Georgios Theodoropoulos

Currently, large language models (LLMs) have made significant progress in the field of psychological counseling. However, existing mental health LLMs overlook a critical issue where they do not consider the fact that different psychological…

Computation and Language · Computer Science 2024-12-19 Haojie Xie , Yirong Chen , Xiaofen Xing , Jingkai Lin , Xiangmin Xu

A digital health twin can be defined as a virtual model of a physical person, in this specific case, a patient. This virtual model is constituted by multidimensional data that can host from clinical, molecular and therapeutic parameters to…

Computers and Society · Computer Science 2022-12-02 Manuel Cossio

Exponential growth in heterogeneous healthcare data arising from electronic health records (EHRs), medical imaging, wearable sensors, and biomedical research has accelerated the adoption of data lakes and centralized architectures capable…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-10-08 Ritesh Chandra , Sonali Agarwal , Navjot Singh , Sadhana Tiwari

Cognitive Twins (CT) are proposed as Digital Twins (DT) with augmented semantic capabilities for identifying the dynamics of virtual model evolution, promoting the understanding of interrelationships between virtual models and enhancing the…

Systems and Control · Electrical Eng. & Systems 2020-01-15 Jinzhi Lu , Xiaochen Zheng , Ali Gharaei , Kostas Kalaboukas , Dimitris Kiritsis

The rise of digital platforms has led to an increasing reliance on technology-driven, home-based healthcare solutions, enabling individuals to monitor their health and share information with healthcare professionals as needed. However,…

Logic in Computer Science · Computer Science 2024-12-13 Subhashis Das , Debashis Naskar , Sara Rodriguez Gonzalez

Quantifying the uncertainty in predictive models is critical for establishing trust and enabling risk-informed decision making for personalized medicine. In contrast to one-size-fits-all approaches that seek to mitigate risk at the…

Computational Engineering, Finance, and Science · Computer Science 2025-05-15 Graham Pash , Umberto Villa , David A. Hormuth , Thomas E. Yankeelov , Karen Willcox

This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer patient prognosis through personalized radiopharmaceutical…

Other Quantitative Biology · Quantitative Biology 2025-11-07 Marc Ryhiner , Yangmeihui Song , Babak Saboury , Gerhard Glatting , Arman Rahmim , Kuangyu Shi

Digital Twins (DTs) are set to become a key enabling technology in future wireless networks, with their use in network management increasing significantly. We developed a DT framework that leverages the heterogeneity of network access…

Networking and Internet Architecture · Computer Science 2024-08-07 Roberto Morabito , Bivek Pandey , Paulius Daubaris , Yasith R Wanigarathna , Sasu Tarkoma

The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in…

With the continued growth of its core technologies, including the Internet of Things (IoT), artificial intelligence (AI), Big Data and data analytics, and edge computing, digital twin (DT) technology has witnessed a significant increase in…

Emerging Technologies · Computer Science 2025-04-23 Ghofran Khalaf , May Itani , Sanaa Sharafeddine

Colorectal cancer, inflammatory bowel disease, and diverticular disease are progressive conditions that affect millions of individuals worldwide and impose substantial clinical and economic burdens. Early detection and personalized…

Emerging Technologies · Computer Science 2026-03-20 Sayed Chhattan Shah , Andrea Townsend-Nicholson , Spiros Denaxas , Pablo Lamata , Manish Chand

While large language models (LLMs) afford new possibilities for user modeling and approximation of human behaviors, they often fail to capture the multidimensional nuances of individual users. In this work, we introduce PersonaTwin, a…

Computation and Language · Computer Science 2025-08-18 Sihan Chen , John P. Lalor , Yi Yang , Ahmed Abbasi

In this article, we present a novel user-centric service provision for immersive communications (IC) in 6G to deal with the uncertainty of individual user behaviors while satisfying unique requirements on the quality of multi-sensory…

Networking and Internet Architecture · Computer Science 2025-03-14 Conghao Zhou , Shisheng Hu , Jie Gao , Xinyu Huang , Weihua Zhuang , Xuemin Shen

Motivation: The importance of clinical data in understanding the pathophysiology of complex disorders has prompted the launch of multiple initiatives designed to generate patient-level data from various modalities. While these studies can…

Clinical trials are indispensable for medical research and the development of new treatments. However, clinical trials often involve thousands of participants and can span several years to complete, with a high probability of failure during…

Machine Learning · Computer Science 2024-07-02 Yue Wang , Tianfan Fu , Yinlong Xu , Zihan Ma , Hongxia Xu , Yingzhou Lu , Bang Du , Honghao Gao , Jian Wu

Digital twin (DT) technologies have emerged as a solution for real-time data-driven modeling of cyber physical systems (CPS) using the vast amount of data available by Internet of Things (IoT) networks. In this position paper, we elucidate…

Networking and Internet Architecture · Computer Science 2022-04-12 Jithin Jagannath , Keyvan Ramezanpour , Anu Jagannath

The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by extensive data collection and advancements in artificial intelligence (AI), alongside traditional biomedical methodologies. However, the reliance…

This review examines current and potential applications of DTs in healthcare, focusing on the integration of multi-omics data using multilayer network approaches in cancer research. We discuss methodologies, tools and platforms commonly…

Molecular Networks · Quantitative Biology 2024-10-11 Hugo Chenel , Malvina Marku , Tim James , Andrei Zinovyev , Vera Pancaldi