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Quantitative computational models play an increasingly important role in modern biology. Such models typically involve many free parameters, and assigning their values is often a substantial obstacle to model development. Directly measuring…

Quantitative Methods · Quantitative Biology 2011-11-09 Ryan N. Gutenkunst , Joshua J. Waterfall , Fergal P. Casey , Kevin S. Brown , Christopher R. Myers , James P. Sethna

The synthesis of complex materials through the self-assembly of particles at the nanoscale provides opportunities for the realization of novel material properties. However, the inverse design process to create experimentally feasible…

Soft Condensed Matter · Physics 2022-03-01 Carl S. Adorf , James Antonaglia , Julia Dshemuchadse , Sharon C. Glotzer

Inverse Patchy Colloids (IPCs) differ from conventional patchy particles because their patches repel (rather than attract) each other and attract (rather than repel) the part of the colloidal surface that is free of patches. These…

Soft Condensed Matter · Physics 2014-12-12 Silvano Ferrari , Emanuela Bianchi , Yura V. Kalyuzhnyi , Gerhard Kahl

Complex crystal structures are composed of multiple local environments, and how this type of order emerges spontaneously during crystal growth has yet to be fully understood. We study crystal growth across various structures and along…

Soft Condensed Matter · Physics 2024-06-03 Maya M. Martirossyan , Matthew Spellings , Hillary Pan , Julia Dshemuchadse

Patchy colloidal platelets with convex, non-spherical shapes have been realized with different materials at length scales ranging from nanometers to microns. While the assembly of these hard shapes tends to maximize edge-to-edge contacts,…

Soft Condensed Matter · Physics 2020-04-22 Carina Karner , Christoph Dellago , Emanuela Bianchi

We investigate the phase behaviour of 2D mixtures of bi-functional and three-functional patchy particles and 3D mixtures of bi-functional and tetra-functional patchy particles by means of Monte Carlo simulations and Wertheim theory. We…

Context. A porous and/or fractal description can generally be applied where particles have undergone coagulation into aggregates. Aims. To characterise finite-sized, porous and fractal particles and to understand the possible limitations of…

Disordered Systems and Neural Networks · Physics 2015-11-09 A. P. Jones

Isotropic pairwise interactions that promote the self assembly of complex particle morphologies have been discovered by inverse design strategies derived from the molecular coarse-graining literature. While such approaches provide an avenue…

Statistical Mechanics · Physics 2019-10-15 Beth A. Lindquist , Ryan B. Jadrich , Michael P. Howard , Thomas M. Truskett

While colloids are promising building blocks for the self-assembly of materials with novel microstructures, their numerous tunable parameters inhibit brute force searching for appropriate parameter combinations that yield self-assembly of a…

Soft Condensed Matter · Physics 2020-03-13 Beth A Lindquist

We calculate the configurational entropy of hard particles confined in a cavity using Monte Carlo integration. Multiple combinations of particle and cavity shapes are considered. For small numbers of particles $N$, we show that the entropy…

Soft Condensed Matter · Physics 2018-04-26 Duanduan Wan , Sharon C. Glotzer

The surface curvature of membranes, interfaces, and substrates plays a crucial role in shaping the self-assembly of particles adsorbed on these surfaces. However, little is known about the interplay between particle anisotropy and surface…

Soft Condensed Matter · Physics 2025-10-30 Gautam Bordia , Thomas P. Russell , Ahmad K. Omar

Biomolecular condensates are formed via liquid-liquid phase separation of proteins, often together with nucleic acids, typically driven by interactions between low-affinity binding sites. The computational study of such condensates that…

Soft Condensed Matter · Physics 2025-01-16 Alena Taskina , Devika Magan , Simon Dannenberg , Stefan Klumpp

Assembly of protein complexes like virus shells, the centriole, the nuclear pore complex or the actin cytoskeleton is strongly determined by their spatial structure. Moreover it is becoming increasingly clear that the reversible nature of…

Subcellular Processes · Quantitative Biology 2014-05-13 Heinrich C. R. Klein , Ulrich S. Schwarz

We study collections of point masses which move freely along the real line and stick together when they collide via perfectly inelastic collisions. We quantify the way particles stick together and explain how to associate a probability…

Analysis of PDEs · Mathematics 2019-12-30 Ryan Hynd

Designing reconfigurable materials based on deformable nanoparticles (NPs) hinges on an understanding of the energetically-favored shapes these NPs can adopt. Using simulations, we show that hollow, deformable patchy NPs tailored with…

Soft Condensed Matter · Physics 2021-01-04 Nicholas E. Brunk , JCS Kadupitiya , Vikram Jadhao

A simple model for functionalized disordered porous media is proposed and the effects of confinement on self-association, percolation and phase behavior of a fluid of patchy particles are studied. The media is formed by a randomly…

Soft Condensed Matter · Physics 2025-03-12 Yurij V. Kalyuzhnyi , Taras Patsahan , Myroslav Holovko , Peter T. Cummings

Adaptive quantum design identifies the best broken-symmetry configurations of atoms and molecules that enable a desired target function response. In this work, numerical optimization is used to design atomic clusters with specified…

Strongly Correlated Electrons · Physics 2009-11-10 Jason Thalken , Yu Chen , A. F. J. Levi , Stephan Haas

Mutually repelling particles form spontaneously ordered clusters when forced into confinement. The clusters may adopt similar spatial arrangements even if the underlying particle interactions are contrastingly different. Here we demonstrate…

Soft Condensed Matter · Physics 2026-02-13 P. D. S. de Lima , R. De La Cour , K. Gaff , J. M. de Araújo , S. J. Cox , M. S. Ferreira , S. Hutzler

Empty liquids represent a wide class of materials whose constituents arrange in a random network through reversible bonds. Many key insights on the physical properties of empty liquids have originated almost independently from the study of…

Soft Condensed Matter · Physics 2021-12-16 John Russo , Fabio Leoni , Fausto Martelli , Francesco Sciortino

We consider a physical system comprising discrete massive particles on the real line whose trajectories interact via perfectly inelastic collision, also known as sticky particles. It turns out that polygons formed in a convex "cumulative…

Dynamical Systems · Mathematics 2021-09-15 Chun-Kai Kevin Chien , Aidan Mager , Laurel Safranek , Jackson Zariski