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Since last 2 decades, High Frequency Oscillations (HFOs) are studied as a promising biomarker to localize the epileptogenic zone of patients with refractory focal epilepsy. As HFOs visual detection is time consuming and subjective,…

Signal Processing · Electrical Eng. & Systems 2023-01-23 Gaëlle Milon-Harnois , Nisrine Jrad , Daniel Schang , Patrick van Bogaert , Pierre Chauvet

High frequency oscillations (HFOs) are a promising biomarker of epileptic brain tissue and activity. HFOs additionally serve as a prototypical example of challenges in the analysis of discrete events in high-temporal resolution,…

Neurons and Cognition · Quantitative Biology 2017-06-13 Stephen V. Gliske , Kevin R. Moon , William C. Stacey , Alfred O. Hero

To achieve seizure freedom, epilepsy surgery requires the complete resection of the epileptogenic brain tissue. In intraoperative ECoG recordings, high frequency oscillations (HFOs) generated by epileptogenic tissue can be used to tailor…

Signal Processing · Electrical Eng. & Systems 2021-08-24 Karla Burelo , Mohammadali Sharifshazileh , Niklaus Krayenbühl , Georgia Ramantani , Giacomo Indiveri , Johannes Sarnthein

In this work, we present a neuromorphic system that combines for the first time a neural recording headstage with a signal-to-spike conversion circuit and a multi-core spiking neural network (SNN) architecture on the same die for recording,…

Signal Processing · Electrical Eng. & Systems 2021-06-09 Mohammadali Sharifshazileh , Karla Burelo , Johannes Sarnthein , Giacomo Indiveri

High Frequency Oscillations (HFOs), rapid bursts of brain activity above 80 Hz, have emerged as a highly specific biomarker for epileptogenic tissue. Recent evidence suggests that HFOs are also present in Alzheimer's Disease (AD),…

Signal Processing · Electrical Eng. & Systems 2026-01-13 Samin Yaser , Mahad Ali , Yang Jiang , Phuc Nguyen , Jing Xiang , Laura J. Brattain

We develop a framework to uncover and analyze dynamical anomalies from massive, nonlinear and non-stationary time series data. The framework consists of three steps: preprocessing of massive data sets to eliminate erroneous data segments,…

Medical Physics · Physics 2016-12-26 Liang Huang , Xuan Ni , William L. Ditto , Mark Spano , Paul R. Carney , Ying-Cheng Lai

Epileptic biomarkers play a crucial role in identifying the origin of seizures, an essential aspect of pre-surgical planning for epilepsy treatment. These biomarkers can vary significantly over time. By studying these temporal fluctuations,…

Signal Processing · Electrical Eng. & Systems 2025-11-11 Mehdi Zekriyapanah Gashti , Mostafa Mohammadpour , Hassan Eshkiki , Vahid Ghanbarizadeh

Objective: The surgical resection of brain areas with high rates of visually identified high frequency oscillations (HFOs) on EEG has been correlated with improved seizure control. However, it can be difficult to distinguish normal from…

Neurons and Cognition · Quantitative Biology 2013-09-05 David Hsu , Murielle Hsu , Heidi L. Grabenstatter , Gregory A. Worrell , Thomas P. Sutula

Over the past decade, high-frequency oscillations (HFOs) have been studied as a promising biomarker for localizing epileptogenic areas in drug-resistant patients requiring pre-surgical intervention, while exploiting intracranial…

Signal Processing · Electrical Eng. & Systems 2024-12-24 Zayneb Sadek , Abir Hadriche , Rahma Maalej , Nawel Jmail

Most of the temporal lobe epilepsy detection approaches are based on hippocampus deformation and use complicated features, resulting, detection is done with complicated features extraction and pre-processing task. In this paper, a new…

Computer Vision and Pattern Recognition · Computer Science 2016-12-30 Zohreh Kohan , Hamidreza Farhidzadeh , Reza Azmi , Behrouz Gholizadeh

High finesse frequency combs (HFC) with large ratio of the frequency spacing to the width of the spectral components have demonstrated remarkable results in many applications such as precision spectroscopy and metrology. We found that low…

Epilepsy is a neurological disorder classified as the second most serious neurological disease known to humanity, after stroke. Localization of the epileptogenic zone is an important step for epileptic patient treatment, which starts with…

Epileptic seizures are neurological disorders characterized by abnormal and excessive electrical activity in the brain, resulting in recurrent seizure events. Electroencephalogram (EEG) signals are widely used for seizure diagnosis due to…

Machine Learning · Computer Science 2026-04-02 Ferdaus Anam Jibon , Fazlul Hasan Siddiqui , F. Deeba , Gahangir Hossain

This contribution reports an application of MultiFractal Detrended Fluctuation Analysis, MFDFA based novel feature extraction technique for automated detection of epilepsy. In fractal geometry, Multifractal Detrended Fluctuation Analysis…

Computer Vision and Pattern Recognition · Computer Science 2017-04-06 S Pratiher , S Chatterjee , R Bose

The diagnosis of epilepsy generally includes a visual inspection of EEG recorded data by the Neurologist, with the purpose of checking the occurrence of transient waveforms called interictal epileptiform discharges. These waveforms have…

Computer Vision and Pattern Recognition · Computer Science 2016-06-08 Andre Rosado , Agostinho C Rosa

Patient-independent detection of epileptic activities based on visual spectral representation of continuous EEG (cEEG) has been widely used for diagnosing epilepsy. However, precise detection remains a considerable challenge due to subtle…

Signal Processing · Electrical Eng. & Systems 2023-05-01 Ruizhe Zheng , Jun Li , Yi Wang , Tian Luo , Yuguo Yu

Real time seizure detection is a fundamental problem in computational neuroscience towards diagnosis and treatment's improvement of epileptic disease. We propose a real-time computational method for tracking and detection of epileptic…

Quantitative Methods · Quantitative Biology 2024-06-17 Ximena Fernández , Diego Mateos

In this paper, a genetic algorithm-based frequency-domain feature search (GAFDS) method is proposed for the electroencephalogram (EEG) analysis of epilepsy. In this method, frequency-domain features are first searched and then combined with…

Machine Learning · Computer Science 2017-01-24 Tingxi Wen , Zhongnan Zhang

The flicker-noise spectroscopy (FNS) approach is used to determine the dynamic characteristics of neuromagnetic responses by analyzing the magnetoencephalographic (MEG) signals recorded as the response of a group of control human subjects…

We investigate the nature of the modifications in the temporal dynamics manifested in the high-frequency EEG spectra of the normal human brain in comparison to the diseased brain undergoing epilepsy. For this purpose, the Fourier…

Chaotic Dynamics · Physics 2025-08-19 Jyotiraj Nath , Shreya Banerjee , Bhaswati Singha Deo , Mayukha Pal , Prasanta K. Panigrahi
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