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Objective: Many recent studies have suggested that brain deformation resulting from a head impact is linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even though several finite element (FE) head…

Traumatic brain injury (TBI) is a complex injury that is hard to predict and diagnose, with many studies focused on associating head kinematics to brain injury risk. Recently, there has been a push towards using computationally expensive…

Machine learning head models (MLHMs) are developed to estimate brain deformation for early detection of traumatic brain injury (TBI). However, the overfitting to simulated impacts and the lack of generalizability caused by distributional…

The surface morphology of the developing mammalian brain is crucial for understanding brain function and dysfunction. Computational modeling offers valuable insights into the underlying mechanisms for early brain folding. Recent findings…

Brain strain and strain rate are effective in predicting traumatic brain injury (TBI) caused by head impacts. However, state-of-the-art finite element modeling (FEM) demands considerable computational time in the computation, limiting its…

Brain tissue deformation resulting from head impacts is primarily caused by rotation and can lead to traumatic brain injury. To quantify brain injury risk based on measurements of kinematics on the head, finite element (FE) models and…

There is increasing evidence on the importance of brain morphology in predicting and classifying mental disorders. However, the vast majority of current shape approaches rely heavily on vertex-wise analysis that may not successfully capture…

Brain deformation caused by a head impact leads to traumatic brain injury (TBI). The maximum principal strain (MPS) was used to measure the extent of brain deformation and predict injury, and the recent evidence has indicated that…

Abnormal cortical folding patterns may be related to neurodevelopmental disorders such as lissencephaly and polymicrogyria. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain…

Strain and strain rate are effective traumatic brain injury predictors. Kinematics-based models estimating these metrics suffer from significant different distributions of both kinematics and the injury metrics across head impact types. To…

Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different types of head impacts (e.g., sports and car crashes) are widely used in risk evaluation.…

Mild traumatic brain injury (mTBI) is a complex syndrome that affects up to 600 per 100,000 individuals, with a particular concentration among military personnel. About half of all mTBI patients experience a diverse array of chronic…

Rotational head motions have been shown to play a key role in traumatic brain injury. There is great interest in developing methods to rapidly predict brain tissue strains and strain rates resulting from rotational head motions to estimate…

Traumatic brain injury (TBI) presents a significant public health challenge, often resulting in mortality or lasting disability. Predicting outcomes such as mortality and Functional Status Scale (FSS) scores can enhance treatment strategies…

Aim: This in silico study sought to identify specific biomarkers for mild traumatic brain injury (mTBI) through the analysis of publicly available gene and miRNA databases, hypothesizing their influence on neuronal structure, axonal…

Mild traumatic brain injury (mTBI, also known as concussion) caused by the head impact is a crucial global public health problem, but the physics of mTBI is still unclear. During the impact, the rapid movement of the head injures the brain,…

Head motion induced by impacts has been deemed as one of the most important measures in brain injury prediction, given that the majority of brain injury metrics use head kinematics as input. Recently, researchers have focused on using fast…

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…

Traumatic brain injuries (TBI) are considered a silent epidemic. It affects many people, from automobiles to sports to service members. In this study, we employed a musculoskeletal head-neck model to understand the effect of impact…

Traumatic brain injury can be caused by various types of head impacts. However, due to different kinematic characteristics, many brain injury risk estimation models are not generalizable across the variety of impacts that humans may…