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Risk prediction capitalizing on emerging human genome findings holds great promise for new prediction and prevention strategies. While the large amounts of genetic data generated from high-throughput technologies offer us a unique…

Methodology · Statistics 2021-01-29 Xiaoxi Shen , Xiaoran Tong , Qing Lu

The recent availability of quantum annealers as cloud-based services has enabled new ways to handle machine learning problems, and several relevant algorithms have been adapted to run on these devices. In a recent work, linear regression…

Quantum Physics · Physics 2025-03-18 Costantino Carugno , Maurizio Ferrari Dacrema , Paolo Cremonesi

Quantile regression provides a framework for modeling statistical quantities of interest other than the conditional mean. The regression methodology is well developed for linear models, but less so for nonparametric models. We consider…

Statistics Theory · Mathematics 2009-09-29 Mi-Ok Kim

Current mainstream post-training quantization methods for large language models typically apply a uniform quantization strategy across all network layers, overlooking the substantial differences in algorithmic suitability among layers. To…

Machine Learning · Computer Science 2026-01-09 Jinhao Zhang , Yunquan Zhang , Daning Chen , JunSun , Zicheng Yan

Quantum Machine Learning (QML) offers tremendous potential but is currently limited by the availability of qubits. We introduce an innovative approach that utilizes pre-trained neural networks to enhance Variational Quantum Circuits (VQC).…

Machine Learning · Computer Science 2024-11-14 Jun Qi , Chao-Han Yang , Samuel Yen-Chi Chen , Pin-Yu Chen , Hector Zenil , Jesper Tegner

Large scale Gaussian process (GP) regression is infeasible for larger data sets due to cubic scaling of flops and quadratic storage involved in working with covariance matrices. Remedies in recent literature focus on divide-and-conquer,…

Methodology · Statistics 2020-05-28 Adam M. Edwards , Robert B. Gramacy

We develop two new variants of alternating direction methods of multipliers (ADMM) and two parallel primal-dual decomposition algorithms to solve a wide range class of constrained convex optimization problems. Our approach relies on a novel…

Optimization and Control · Mathematics 2018-06-15 Quoc Tran-Dinh , Yuzixuan Zhu

Augmented Lagrangian Methods (ALMs) are widely employed in solving constrained optimizations, and some efficient solvers are developed based on this framework. Under the quadratic growth assumption, it is known that the dual iterates and…

Optimization and Control · Mathematics 2024-10-31 Feng-Yi Liao , Lijun Ding , Yang Zheng

We propose a new bundle-based augmented Lagrangian framework for solving constrained convex problems. Unlike the classical (inexact) augmented Lagrangian method (ALM) that has a nested double-loop structure, our framework features a…

Optimization and Control · Mathematics 2025-02-14 Feng-Yi Liao , Yang Zheng

Clinical antimicrobial therapy requires the dynamic integration of pathogen profiles,host factors, pharmacological properties of antimicrobials,and the severity of infection. This complexity imposes fundamental limitations on the…

Artificial Intelligence · Computer Science 2025-11-27 Zhe Li , Yehan Qiu , Yujie Chen , Xiang Zhou

Large language models (LLMs) show strong capabilities in general reasoning but typically lack reliability in scientific domains like quantum mechanics, which demand strict adherence to physical constraints. This limitation arises from the…

Artificial Intelligence · Computer Science 2026-04-21 Songxin Qu , Tai-Ping Sun , Yun-Jie Wang , Huan-Yu Liu , Cheng Xue , Xiao-Fan Xu , Han Fang , Yang Yang , Yu-Chun Wu , Guo-Ping Guo , Zhao-Yun Chen

A preconditioning strategy for the Powell-Hestenes-Rockafellar Augmented Lagrangian method (ALM) is presented. The scheme exploits the structure of the Augmented Lagrangian Hessian. It is a modular preconditioner consisting of two blocks.…

Optimization and Control · Mathematics 2017-02-24 AM Sajo-Castelli

In this paper, we aim to solve high dimensional convex quadratic programming (QP) problems with a large number of quadratic terms, linear equality and inequality constraints. In order to solve the targeted {\bf QP} problems to a desired…

Optimization and Control · Mathematics 2022-01-31 Ling Liang , Xudong Li , Defeng Sun , Kim-Chuan Toh

We develop a decomposition method based on the augmented Lagrangian framework to solve a broad family of semidefinite programming problems, possibly with nonlinear objective functions, nonsmooth regularization, and general linear…

Optimization and Control · Mathematics 2023-03-08 Yifei Wang , Kangkang Deng , Haoyang Liu , Zaiwen Wen

Monitoring changes inside a reservoir in real time is crucial for the success of CO2 injection and long-term storage. Machine learning (ML) is well-suited for real-time CO2 monitoring because of its computational efficiency. However, most…

Geophysics · Physics 2022-12-12 Yanhua Liu , Xitong Zhang , Ilya Tsvankin , Youzuo Lin

Shape-constrained convex regression problem deals with fitting a convex function to the observed data, where additional constraints are imposed, such as component-wise monotonicity and uniform Lipschitz continuity. This paper provides a…

Optimization and Control · Mathematics 2021-11-23 Meixia Lin , Defeng Sun , Kim-Chuan Toh

Reinforcement learning with verifiable rewards (RLVR) has become a trending paradigm for training reasoning large language models (LLMs). However, due to the autoregressive decoding nature of LLMs, the rollout process becomes the efficiency…

Machine Learning · Computer Science 2026-02-17 Yuhang Li , Reena Elangovan , Xin Dong , Priyadarshini Panda , Brucek Khailany

There is currently a huge effort to understand the potential and limitations of variational quantum machine learning (QML) based on the optimization of parameterized quantum circuits. Recent proposals toward dequantizing variational QML…

Quantum Physics · Physics 2025-04-01 Ryan Sweke , Seongwook Shin , Elies Gil-Fuster

This study presents an efficient incremental/decremental approach for big streams based on Kernel Ridge Regression (KRR), a frequently used data analysis in cloud centers. To avoid reanalyzing the whole dataset whenever sensors receive new…

Machine Learning · Computer Science 2017-11-10 Bo-Wei Chen , Nik Nailah Binti Abdullah , Sangoh Park

Kernel logistic regression (KLR) is a widely used supervised learning method for binary and multi-class classification, which provides estimates of the conditional probabilities of class membership for the data points. Unlike other kernel…

Machine Learning · Computer Science 2025-12-23 Antonio Consolo , Andrea Manno , Edoardo Amaldi
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