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Medical large language models (LLMs) achieve impressive performance on standardized benchmarks, yet these evaluations fail to capture the complexity of real clinical encounters where patients exhibit memory gaps, limited health literacy,…

Artificial Intelligence · Computer Science 2026-04-14 Sina Mansouri , Mohit Marvania , Vibhavari Ashok Shihorkar , Han Ngoc Tran , Kazhal Shafiei , Mehrdad Fazli , Yikuan Li , Ziwei Zhu

Regulatory compliance reporting in the pharmaceutical industry relies on detailed tables, but these are often under-utilized beyond compliance due to their unstructured format and arbitrary content. Extracting and semantically representing…

Computation and Language · Computer Science 2024-10-08 Narayanan PP , Anantharaman Palacode Narayana Iyer

Network device and system health management is the foundation of modern network operations and maintenance. Traditional health management methods, relying on expert identification or simple rule-based algorithms, struggle to cope with the…

Networking and Internet Architecture · Computer Science 2026-03-24 Fengxiao Tang , Xiaonan Wang , Xun Yuan , Linfeng Luo , Ming Zhao , Tianchi Huang , Nei Kato

Large language models (LLMs) have achieved remarkable performance on diverse benchmarks, yet existing evaluation practices largely rely on coarse summary metrics that obscure underlying reasoning abilities. In this work, we propose novel…

Methodology · Statistics 2026-03-17 Jia Liu , Zhiyu Xu , Yuqi Gu

This research introduces a transformative framework for integrating Vision-Enhanced Large Language Models (LLMs) with advanced transformer-based architectures to tackle challenges in high-resolution image synthesis and multimodal data…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Karthikeya KV

Specializing large language models (LLMs) for local deployment in domain-specific use cases is necessary for strong performance while meeting latency and privacy constraints. However, conventional task-specific adaptation approaches do not…

Machine Learning · Computer Science 2024-12-20 Lanxiang Hu , Tajana Rosing , Hao Zhang

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

Large language models (LLMs) hold promise for transforming healthcare, from streamlining administrative and clinical workflows to enriching patient engagement and advancing clinical decision-making. However, their successful integration…

Computers and Society · Computer Science 2025-04-04 Mohammed Al-Garadi , Tushar Mungle , Abdulaziz Ahmed , Abeed Sarker , Zhuqi Miao , Michael E. Matheny

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

Interpretability remains a key challenge for deploying large language models (LLMs) in clinical settings such as Alzheimer's disease progression diagnosis, where early and trustworthy predictions are essential. Existing attribution methods…

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Electronic Health Records (EHRs) offer considerable potential for clinical prediction, but their complexity and heterogeneity challenge traditional machine learning. Domain-specific EHR foundation models trained on unlabeled EHR data have…

Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Structured data offers a sophisticated mechanism for the organization of information. Existing methodologies for the text-serialization of structured data in the context of large language models fail to adequately address the heterogeneity…

Computation and Language · Computer Science 2024-02-20 YiQiu Guo , Yuchen Yang , Ya Zhang , Yu Wang , Yanfeng Wang

Large language models (LLMs) have demonstrated broad utility across molecular domains, spanning drug discovery and materials design. Analyzing LLMs' latent representations is crucial for elucidating their underlying mechanisms, improving…

Machine Learning · Computer Science 2026-02-03 Zhuoran Li , Xu Sun , Wanyu Lin , Jiannong Cao

Recently, large language models (LLMs) have achieved remarkable breakthroughs, revolutionizing the natural language processing domain and beyond. Due to immense parameter sizes, fine-tuning these models with private data for diverse…

Machine Learning · Computer Science 2025-05-06 Zheng Lin , Yuxin Zhang , Zhe Chen , Zihan Fang , Xianhao Chen , Praneeth Vepakomma , Wei Ni , Jun Luo , Yue Gao

Large language models (LLMs) have demonstrated exceptional proficiency in understanding and generating human language, but efficient inference on resource-constrained embedded devices remains challenging due to large model sizes and…

Hardware Architecture · Computer Science 2025-07-15 Weihong Xu , Haein Choi , Po-kai Hsu , Shimeng Yu , Tajana Rosing

With the rapid advancement of generative artificial intelligence, large language models (LLMs) are increasingly adopted in industrial domains, offering new opportunities for Prognostics and Health Management (PHM). These models help address…

Artificial Intelligence · Computer Science 2025-08-05 Puyu Yang , Laifa Tao , Zijian Huang , Haifei Liu , Wenyan Cao , Hao Ji , Jianan Qiu , Qixuan Huang , Xuanyuan Su , Yuhang Xie , Jun Zhang , Shangyu Li , Chen Lu , Zhixuan Lian
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