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Medical Large language models achieve strong scores on standard benchmarks; however, the transfer of those results to safe and reliable performance in clinical workflows remains a challenge. This survey reframes evaluation through a…

Evaluating large language models (LLMs) for clinical documentation tasks such as SOAP note generation remains challenging. Unlike standard summarization, these tasks require clinical abstraction, normalization of colloquial language, and…

Artificial Intelligence · Computer Science 2026-04-17 Bhavik Vachhani , Kush Shrisvastava , Pranshu Nema , Sai Chiranthan

In the United States, 25% or greater than 200 billion dollars of hospital spending accounts for administrative costs that involve services for medical coding and billing. With the increasing number of patient records, manual assignment of…

Computation and Language · Computer Science 2020-03-18 A. K. Bhavani Singh , Mounika Guntu , Ananth Reddy Bhimireddy , Judy W. Gichoya , Saptarshi Purkayastha

The advent of large language models trained on code (code LLMs) has led to significant progress in language-to-code generation. State-of-the-art approaches in this area combine LLM decoding with sample pruning and reranking using test cases…

Machine Learning · Computer Science 2023-09-04 Ansong Ni , Srini Iyer , Dragomir Radev , Ves Stoyanov , Wen-tau Yih , Sida I. Wang , Xi Victoria Lin

Cost models in healthcare research must balance interpretability, accuracy, and parameter consistency. However, interpretable models often struggle to achieve both accuracy and consistency. Ordinary least squares (OLS) models for…

Machine Learning · Computer Science 2025-11-10 Chi-Ken Lu , David Alonge , Nicole Richardson , Bruno Richard

Reliability in cell type annotation is challenging in single-cell RNA-sequencing data analysis because both expert-driven and automated methods can be biased or constrained by their training data, especially for novel or rare cell types.…

Quantitative Methods · Quantitative Biology 2024-09-25 Wenjin Ye , Yuanchen Ma , Junkai Xiang , Hongjie Liang , Tao Wang , Qiuling Xiang , Andy Peng Xiang , Wu Song , Weiqiang Li , Weijun Huang

Automating hardware design could obviate a significant amount of human error from the engineering process and lead to fewer errors. Verilog is a popular hardware description language to model and design digital systems, thus generating…

Programming Languages · Computer Science 2022-12-22 Shailja Thakur , Baleegh Ahmad , Zhenxing Fan , Hammond Pearce , Benjamin Tan , Ramesh Karri , Brendan Dolan-Gavitt , Siddharth Garg

A decade of rapid advances in artificial intelligence (AI) has opened new opportunities for clinical decision support systems (CDSS), with large language models (LLMs) demonstrating strong reasoning abilities on timely medical tasks.…

Computation and Language · Computer Science 2025-11-25 Heejoon Koo

Large Language Models (LLMs) have shown growing potential in molecular sciences, but they often produce chemically inaccurate descriptions and struggle to recognize or justify potential errors. This raises important concerns about their…

Chemical Physics · Physics 2025-10-29 Yuyang Wu , Jinhui Ye , Shuhao Zhang , Lu Dai , Yonatan Bisk , Olexandr Isayev

Matching cancer patients to clinical trials is essential for advancing treatment and patient care. However, the inconsistent format of medical free text documents and complex trial eligibility criteria make this process extremely…

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in…

Computation and Language · Computer Science 2026-01-19 Parker Seegmiller , Joseph Gatto , Sarah E. Greer , Ganza Belise Isingizwe , Rohan Ray , Timothy E. Burdick , Sarah Masud Preum

Veterinary medical records represent a large data resource for application to veterinary and One Health clinical research efforts. Use of the data is limited by interoperability challenges including inconsistent data formats and data…

Computation and Language · Computer Science 2025-08-22 Mayla R. Boguslav , Adam Kiehl , David Kott , G. Joseph Strecker , Tracy Webb , Nadia Saklou , Terri Ward , Michael Kirby

Large language models (LLMs) are increasingly applied in multilingual contexts, yet their capacity for consistent, logically grounded alignment across languages remains underexplored. We present a controlled evaluation framework for…

Computation and Language · Computer Science 2025-08-21 Samir Abdaljalil , Erchin Serpedin , Khalid Qaraqe , Hasan Kurban

While Large Language Models (LLMs) have demonstrated remarkable capabilities in code generation, they often produce solutions that lack guarantees of correctness, robustness, and efficiency. This limitation is particularly acute in domains…

Software Engineering · Computer Science 2025-09-04 Yueke Zhang , Yifan Zhang , Kevin Leach , Yu Huang

Large language models (LLMs) have demonstrated impressive capabilities across a wide range of coding tasks, including summarization, translation, completion, and code generation. Despite these advances, detecting code vulnerabilities…

Software Engineering · Computer Science 2026-02-05 Md Abdul Hannan , Ronghao Ni , Chi Zhang , Limin Jia , Ravi Mangal , Corina S. Pasareanu

Medical coding is a complex task, requiring assignment of a subset of over 72,000 ICD codes to a patient's notes. Modern natural language processing approaches to these tasks have been challenged by the length of the input and size of the…

Machine Learning · Computer Science 2022-08-17 Jay DeYoung , Han-Chin Shing , Luyang Kong , Christopher Winestock , Chaitanya Shivade

Real-world clinical text-to-SQL requires reasoning over heterogeneous EHR tables, temporal windows, and patient-similarity cohorts to produce executable queries. We introduce CLINSQL, a benchmark of 633 expert-annotated tasks on MIMIC-IV…

Computation and Language · Computer Science 2026-01-16 Yifei Shen , Yilun Zhao , Justice Ou , Tinglin Huang , Arman Cohan

In medical coding, experts map unstructured clinical notes to alphanumeric codes for diagnoses and procedures. We introduce Code Like Humans: a new agentic framework for medical coding with large language models. It implements official…

Artificial Intelligence · Computer Science 2025-10-09 Andreas Motzfeldt , Joakim Edin , Casper L. Christensen , Christian Hardmeier , Lars Maaløe , Anna Rogers

Large language models (LLMs) are increasingly used to create content in regulated domains such as pharmaceuticals, where outputs must be scientifically accurate and legally compliant. Manual quality control (QC) is slow, error prone, and…

Machine Learning · Computer Science 2026-02-13 Suyash Mishra , Qiang Li , Anubhav Girdhar

Large Language Models (LLMs) demonstrate remarkable performance in semantic understanding and generation, yet accurately assessing their output reliability remains a significant challenge. While numerous studies have explored calibration…

Artificial Intelligence · Computer Science 2024-12-18 Liangru Xie , Hui Liu , Jingying Zeng , Xianfeng Tang , Yan Han , Chen Luo , Jing Huang , Zhen Li , Suhang Wang , Qi He
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