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The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF). To extract the mutational…

Methodology · Statistics 2022-11-02 Marta Pelizzola , Ragnhild Laursen , Asger Hobolth

Non-negative Matrix Factorization (NMF) is a popular tool for data exploration. Bayesian NMF promises to also characterize uncertainty in the factorization. Unfortunately, current inference approaches such as MCMC mix slowly and tend to get…

Machine Learning · Statistics 2016-10-28 M. Arjumand Masood , Finale Doshi-Velez

Non-negative Matrix Factorization (NMF) is an intensively used technique for obtaining parts-based, lower dimensional and non-negative representation. Researchers in biology, medicine, pharmacy and other fields often prefer NMF over other…

Machine Learning · Computer Science 2025-02-04 Matej Mihelčić , Pauli Miettinen

The Nonnegative Matrix Factorization (NMF) of the rating matrix has shown to be an effective method to tackle the recommendation problem. In this paper we propose new methods based on the NMF of the rating matrix and we compare them with…

Machine Learning · Computer Science 2019-08-30 Gianna M. Del Corso , Francesco Romani

In this paper we explore avenues for improving the reliability of dimensionality reduction methods such as Non-Negative Matrix Factorization (NMF) as interpretive exploratory data analysis tools. We first explore the difficulties of the…

Artificial Intelligence · Computer Science 2009-04-22 Nikolaos Vasiloglou , Alexander G. Gray , David V. Anderson

Diet plays a crucial role in health, and understanding the causal effects of dietary patterns is essential for informing public health policy and personalized nutrition strategies. However, causal inference in nutritional epidemiology faces…

Methodology · Statistics 2026-01-26 Dafne Zorzetto , Zizhao Xie , Julian Stamp , Arman Oganisian , Roberta De Vito

Nonnegative matrix factorization (NMF) has been widely used to learn low-dimensional representations of data. However, NMF pays the same attention to all attributes of a data point, which inevitably leads to inaccurate representation. For…

Machine Learning · Computer Science 2021-11-30 Jiao Wei , Can Tong , Bingxue Wu , Qiang He , Shouliang Qi , Yudong Yao , Yueyang Teng

Microbiome `omics approaches can reveal intriguing relationships between the human microbiome and certain disease states. Along with the identification of specific bacteria taxa associated with diseases, recent scientific advancements…

Applications · Statistics 2019-10-07 Shuang Jiang , Guanghua Xiao , Andrew Y. Koh , Qiwei Li , Xiaowei Zhan

Nonnegative matrix factorization (NMF) has an established reputation as a useful data analysis technique in numerous applications. However, its usage in practical situations is undergoing challenges in recent years. The fundamental factor…

Machine Learning · Computer Science 2016-05-04 Mariano Tepper , Guillermo Sapiro

Bayesian factor models are widely used for dimensionality reduction and pattern discovery in high-dimensional datasets across diverse fields. These models typically focus on imposing priors on factor loading to induce sparsity and improve…

Methodology · Statistics 2025-04-08 Yingjie Huang , Dafne Zorzetto , Roberta De Vito

Non-negative matrix factorization (NMF) is a fundamental matrix decomposition technique that is used primarily for dimensionality reduction and is increasing in popularity in the biological domain. Although finding a unique NMF is generally…

Information Theory · Computer Science 2021-08-23 Rami Nasser , Yonina C. Eldar , Roded Sharan

Microbiome research has immense potential for unlocking insights into human health and disease. A common goal in human microbiome research is identifying subgroups of individuals with similar microbial composition that may be linked to…

Methodology · Statistics 2025-08-21 Suppapat Korsurat , Matthew D. Koslovsky

In this work we perform some mathematical analysis on non-negative matrix factorizations (NMF) and apply NMF to some imaging and inverse problems. We will propose a sparse low-rank approximation of big positive data and images in terms of…

Optimization and Control · Mathematics 2015-04-24 Yat Tin Chow , Kazufumi Ito , Jun Zou

Dimensionality reduction and matrix factorization techniques are important and useful machine-learning techniques in many fields. Nonnegative matrix factorization (NMF) is particularly useful for spectral analysis and image processing in…

Instrumentation and Methods for Astrophysics · Physics 2016-12-20 Guangtun Zhu

Non-negative matrix factorisation (NMF) is a widely used tool for unsupervised learning and feature extraction, with applications ranging from genomics to text analysis and signal processing. Standard formulations of NMF are typically…

Machine Learning · Computer Science 2026-03-11 Elisabeth Sommer James , Asger Hobolth , Marta Pelizzola

Non-negative matrix factorization (NMF) is widely used for dimensionality reduction and interpretable analysis, but standard formulations are unsupervised and cannot directly exploit class labels. Existing supervised or semi-supervised…

Machine Learning · Computer Science 2025-10-14 Kenichi Satoh

This paper presents a new modeling strategy for joint unsupervised analysis of multiple high-throughput biological studies. As in Multi-study Factor Analysis, our goals are to identify both common factors shared across studies and…

Applications · Statistics 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

Collaborative filtering generates recommendations by exploiting user-item similarities based on rating data, which often contains numerous unrated items. To predict scores for unrated items, matrix factorization techniques such as…

Statistical Mechanics · Physics 2025-07-30 Yukino Terui , Yuka Inoue , Yohei Hamakawa , Kosuke Tatsumura , Kazue Kudo

Non-negative matrix factorization (NMF) is one of the most popular decomposition techniques for multivariate data. NMF is a core method for many machine-learning related computational problems, such as data compression, feature extraction,…

Numerical Analysis · Computer Science 2017-12-07 Gabriele Torre , Michael Graber

Non-negative matrix factorization (NMF) and non-negative tensor factorization (NTF) decompose non-negative high-dimensional data into non-negative low-rank components. NMF and NTF methods are popular for their intrinsic interpretability and…

Machine Learning · Computer Science 2024-12-02 Alexander Sietsema , Zerrin Vural , James Chapman , Yotam Yaniv , Deanna Needell