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Quantum simulation of quantum chemistry is one of the most compelling applications of quantum computing. It is of particular importance in areas ranging from materials science, biochemistry and condensed matter physics. Here, we propose a…

Quantum Physics · Physics 2020-02-25 Shijie Wei , Hang Li , GuiLu Long

The limited number of qubits is a major bottleneck in Quantum Approximate Optimization Algorithm (QAOA) for large-scale combinatorial optimization in the Noisy Intermediate-Scale Quantum (NISQ) era. To make progress, existing techniques…

Emerging Technologies · Computer Science 2026-04-21 Xiaoyu Ma , Fang Fang , Ximing Xie , Xianbin Wang , Lajos Hanzo

As quantum processors grow, new performance benchmarks are required to capture the full quality of the devices at scale. While quantum volume is an excellent benchmark, it focuses on the highest quality subset of the device and so is unable…

The utility of effective model spaces in quantum simulations of non-relativistic quantum many-body systems is explored in the context of the Lipkin-Meshkov-Glick model of interacting fermions. We introduce an iterative…

Quantum Physics · Physics 2023-08-25 Caroline E. P. Robin , Martin J. Savage

Fully Homomorphic Encryption (FHE) enables computation directly on encrypted data but incurs massive computational and memory overheads, often exceeding plaintext execution by several orders of magnitude. While custom ASIC accelerators can…

Neural networks with sub-microsecond inference latency are required by many critical applications. Targeting such applications deployed on FPGAs, we present High Granularity Quantization (HGQ), a quantization-aware training framework that…

Machine Learning · Computer Science 2025-12-22 Chang Sun , Zhiqiang Que , Thea K. Årrestad , Vladimir Loncar , Jennifer Ngadiuba , Wayne Luk , Maria Spiropulu

Variational quantum algorithms (VQAs) are a modern family of quantum algorithms designed to solve optimization problems using a quantum computer. Typically VQAs rely on a feedback loop between the quantum device and a classical optimization…

Quantum Physics · Physics 2022-08-26 Alexey Uvarov

High Bandwidth Memory (HBM) provides massive aggregated memory bandwidth by exposing multiple memory channels to the processing units. To achieve high performance, an accelerator built on top of an FPGA configured with HBM (i.e., FPGA-HBM…

Hardware Architecture · Computer Science 2021-10-13 Kexin Li , Chenhao Liu , Zhiyuan Shao , Zeke Wang , Minkang Wu , Jiajie Chen , Xiaofei Liao , Hai Jin

Current quantum computers are limited in the number of qubits and coherence time, constraining the algorithms executable with sufficient fidelity. The variational quantum eigensolver (VQE) is an algorithm to find an approximate ground state…

Quantum Physics · Physics 2023-01-24 Luca Erhart , Kosuke Mitarai , Wataru Mizukami , Keisuke Fujii

Cloud-accessible quantum processors enable direct execution of quantum algorithms on heterogeneous hardware platforms. Unlike classical systems, however, identical quantum circuits may exhibit substantially different behavior across devices…

Quantum Physics · Physics 2026-01-12 Askar Oralkhan , Temirlan Zhaxalykov

Variational Quantum Eigensolvers (VQEs) are a powerful class of hybrid quantum-classical algorithms designed to approximate the ground state of a quantum system described by its Hamiltonian. VQEs hold promise for various applications,…

Quantum Physics · Physics 2025-02-04 Kim A. Nicoli , Luca J. Wagner , Lena Funcke

Researchers and industries are increasingly drawn to quantum computing for its computational potential. However, validating new quantum algorithms is challenging due to the limitations of current quantum devices. Software simulators are…

While quantum algorithms for simulation exhibit better asymptotic scaling than their classical counterparts, they currently cannot be implemented on real-world devices. Instead, chemists and computer scientists rely on costly classical…

Quantum Physics · Physics 2022-06-03 Christopher Kang , Nicholas P. Bauman , Sriram Krishnamoorthy , Karol Kowalski

The variational quantum eigensolver (or VQE) uses the variational principle to compute the ground state energy of a Hamiltonian, a problem that is central to quantum chemistry and condensed matter physics. Conventional computing methods are…

Variational quantum eigensolver (VQE) is promising to show quantum advantage on near-term noisy-intermediate-scale quantum (NISQ) computers. One central problem of VQE is the effect of noise, especially the physical noise on realistic…

Quantum Physics · Physics 2021-09-30 Jinfeng Zeng , Zipeng Wu , Chenfeng Cao , Chao Zhang , Shiyao Hou , Pengxiang Xu , Bei Zeng

AlphaFold has achieved groundbreaking advancements in protein structure prediction, exerting profound influence across biology, medicine, and drug discovery. However, its reliance on multiple sequence alignment (MSA) is inherently…

Quantum Physics · Physics 2025-06-03 Rong Chen , Quan-Xin Mei , Wen-Ding Zhao , Lin Yao , Hao-Xiang Yang , Shun-Yao Zhang , Jiao Chen , Hong-Lin Li

In this paper we present Quanrum Encoded Quantum Evolutionary Algorithm (QEQEA) and compare its performance against a a classical GPU accelerated Genetic Algorithm (GPUGA). The proposed QEQEA differs from existing quantum evolutionary…

Quantum Physics · Physics 2018-10-01 Georgiy Krylov , Martin Lukac

Efficiently encoding classical visual data into quantum states is essential for realizing practical quantum neural networks (QNNs). However, existing encoding schemes often discard spatial and semantic information when adapting…

Quantum Physics · Physics 2025-11-20 Yuhu Lu , Jinjing Shi

The rapid development of noisy intermediate-scale quantum (NISQ) devices has raised the question of whether or not these devices will find commercial use. Unfortunately, a major shortcoming of many proposed NISQ-amenable algorithms, such as…

Quantum Physics · Physics 2021-10-22 Amara Katabarwa , Alex Kunitsa , Borja Peropadre , Peter Johnson

The ability to simulate a fermionic system on a quantum computer is expected to revolutionize chemical engineering, materials design, nuclear physics, to name a few. Thus, optimizing the simulation circuits is of significance in harnessing…

Quantum Physics · Physics 2021-07-28 Qingfeng Wang , Ming Li , Christopher Monroe , Yunseong Nam
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