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Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

Medical image analysis is essential to clinical diagnosis and treatment, which is increasingly supported by multi-modal large language models (MLLMs). However, previous research has primarily focused on 2D medical images, leaving 3D images…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Fan Bai , Yuxin Du , Tiejun Huang , Max Q. -H. Meng , Bo Zhao

Developing an integrated many-to-many framework leveraging multimodal data for multiple tasks is crucial to unifying healthcare applications ranging from diagnoses to operations. In resource-constrained hospital environments, a scalable and…

Machine Learning · Computer Science 2024-06-11 Dimitris Bertsimas , Yu Ma

We present a systematic investigation of Multi-modal Retrieval Augmented Multi-modal Generation (M$^2$RAG), a novel task that enables foundation models to process multi-modal web content and generate multi-modal responses, which exhibits…

Computation and Language · Computer Science 2025-05-26 Zi-Ao Ma , Tian Lan , Rong-Cheng Tu , Yong Hu , Yu-Shi Zhu , Tong Zhang , Heyan Huang , Zhijing Wu , Xian-Ling Mao

Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Most organizational data in this world are stored as documents, and visual retrieval plays a crucial role in unlocking the collective intelligence from all these documents. However, existing benchmarks focus on English-only document…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Jian Chen , Ming Li , Jihyung Kil , Chenguang Wang , Tong Yu , Ryan Rossi , Tianyi Zhou , Changyou Chen , Ruiyi Zhang

Multimodal foundation models hold significant potential for automating radiology report generation, thereby assisting clinicians in diagnosing cardiac diseases. However, generated reports often suffer from serious factual inaccuracy. In…

Computation and Language · Computer Science 2025-02-07 Liwen Sun , James Zhao , Megan Han , Chenyan Xiong

Developing effective biomedical retrieval models is important for excelling at knowledge-intensive biomedical tasks but still challenging due to the deficiency of sufficient publicly annotated biomedical data and computational resources. We…

Computation and Language · Computer Science 2024-10-07 Ran Xu , Wenqi Shi , Yue Yu , Yuchen Zhuang , Yanqiao Zhu , May D. Wang , Joyce C. Ho , Chao Zhang , Carl Yang

Existing multimodal retrieval benchmarks primarily focus on evaluating whether models can retrieve and utilize external textual knowledge for question answering. However, there are scenarios where retrieving visual information is either…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Wenbo Hu , Jia-Chen Gu , Zi-Yi Dou , Mohsen Fayyaz , Pan Lu , Kai-Wei Chang , Nanyun Peng

Medical image retrieval is essential for clinical decision-making and translational research, relying on discriminative visual representations. Yet, current methods remain fragmented, relying on separate architectures and training…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Che Liu , Zheng Jiang , Chengyu Fang , Heng Guo , Yan-Jie Zhou , Jiaqi Qu , Le Lu , Minfeng Xu

Multimodal retrieval is becoming a crucial component of modern AI applications, yet its evaluation lags behind the demands of more realistic and challenging scenarios. Existing benchmarks primarily probe surface-level semantic…

Information Retrieval · Computer Science 2025-10-01 Junjie Zhou , Ze Liu , Lei Xiong , Jin-Ge Yao , Yueze Wang , Shitao Xiao , Fenfen Lin , Miguel Hu Chen , Zhicheng Dou , Siqi Bao , Defu Lian , Yongping Xiong , Zheng Liu

While Retrieval Augmented Generation (RAG) is now widely adopted to enhance LLMs, evaluating its true performance benefits in a reproducible and interpretable way remains a major hurdle. Existing methods often fall short: they lack domain…

Information Retrieval · Computer Science 2025-08-11 Jiaxuan Liang , Shide Zhou , Kailong Wang

Artificial Intelligence (AI) has demonstrated significant potential in healthcare, particularly in disease diagnosis and treatment planning. Recent progress in Medical Large Vision-Language Models (Med-LVLMs) has opened up new possibilities…

Machine Learning · Computer Science 2025-03-04 Peng Xia , Kangyu Zhu , Haoran Li , Tianze Wang , Weijia Shi , Sheng Wang , Linjun Zhang , James Zou , Huaxiu Yao

Retrieval-augmented generation (RAG) improves large language model reliability by grounding generated responses in external evidence. However, RAG performance depends on the relevance of retrieved passages, the quality of evidence ranking,…

Information Retrieval · Computer Science 2026-05-05 Fariba Afrin Irany , Sampson Akwafuo

Access to diverse, well-annotated medical images with interactive learning tools is fundamental for training practitioners in medicine and related fields to improve their diagnostic skills and understanding of anatomical structures. While…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Miguel Diaz Benito , Cecilia Diana Albelda , Alvaro Garcia Martin , Jesus Bescos Cano , Marcos Escudero-Vinolo , Juan C. SanMiguel

Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text…

Machine Learning · Computer Science 2025-12-12 Haolin Li , Tianjie Dai , Zhe Chen , Siyuan Du , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Retrieval-augmented generation (RAG) is a common way to ground language models in external documents and up-to-date information. Classical retrieval systems relied on lexical methods such as BM25, which rank documents by term overlap with…

Computation and Language · Computer Science 2026-03-05 Martin Asenov , Kenza Benkirane , Dan Goldwater , Aneiss Ghodsi

Objective: Applying large language models (LLMs) to the clinical domain is challenging due to the context-heavy nature of processing medical records. Retrieval-augmented generation (RAG) offers a solution by facilitating reasoning over…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Timothy A. Miller , Yanjun Gao , Matthew M. Churpek , Anoop Mayampurath , Dmitriy Dligach , Majid Afshar

Multimodal Retrieval-Augmented Generation (MRAG) enhances reasoning capabilities by integrating external knowledge. However, existing benchmarks primarily focus on simple image-text interactions, overlooking complex visual formats like…

Artificial Intelligence · Computer Science 2025-02-21 Yuming Yang , Jiang Zhong , Li Jin , Jingwang Huang , Jingpeng Gao , Qing Liu , Yang Bai , Jingyuan Zhang , Rui Jiang , Kaiwen Wei