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Quantum heuristics have shown promise in solving various optimization problems, including lattice protein folding. Equally relevant is the inverse problem, protein design, where one seeks sequences that fold to a given target structure. The…

Simulating open quantum systems on quantum computers presents a fundamental challenge: open quantum dynamics are intrinsically nonunitary, whereas quantum computers operate through unitary evolution. Conventional approaches overcome this…

Quantum Physics · Physics 2025-10-27 Sameer Dambal , Akira Sone , Yu Zhang

In 2017, John Preskill defined Noisy Intermediate Scale Quantum (NISQ) computers as an intermediate step on the road to large scale error corrected fault-tolerant quantum computers (FTQC). The NISQ regime corresponds to noisy qubit quantum…

Quantum Physics · Physics 2023-06-13 Olivier Ezratty

Variational quantum algorithms (VQAs) offer the most promising path to obtaining quantum advantages via noisy intermediate-scale quantum (NISQ) processors. Such systems leverage classical optimization to tune the parameters of a…

Quantum Physics · Physics 2022-09-26 Sharu Theresa Jose , Osvaldo Simeone

Classical verification of quantum learning allows classical clients to reliably leverage quantum computing advantages by interacting with untrusted quantum servers. Yet, current quantum devices available in practice suffers from a variety…

Quantum Physics · Physics 2024-11-15 Yinghao Ma , Jiaxi Su , Dong-Ling Deng

Applications such as simulating complicated quantum systems or solving large-scale linear algebra problems are very challenging for classical computers due to the extremely high computational cost. Quantum computers promise a solution,…

Variational quantum algorithms have been one of the most intensively studied applications for near-term quantum computing applications. The noisy intermediate-scale quantum (NISQ) regime, where small enough algorithms can be run…

Quantum Physics · Physics 2023-01-19 Sebastian Brandhofer , Simon Devitt , Ilia Polian

Quantum computation holds the promise of solving certain complex problems exponentially faster than classical computers. However, the high prevalent noise in current quantum devices impedes the accurate execution of even basic algorithms.…

Quantum Physics · Physics 2026-05-13 Prithviraj Prabhu

Crosstalk is a major source of noise in Noisy Intermediate-Scale Quantum (NISQ) systems and is a fundamental challenge for hardware design. When multiple instructions are executed in parallel, crosstalk between the instructions can corrupt…

Quantum Physics · Physics 2020-01-10 Prakash Murali , David C. McKay , Margaret Martonosi , Ali Javadi-Abhari

Quantum computing has been moving from a theoretical phase to practical one, presenting daunting challenges in implementing physical qubits, which are subjected to noises from the surrounding environment. These quantum noises are ubiquitous…

Neutral atom Quantum Processing Units (QPUs) are emerging as a popular quantum computing technology due to their large qubit counts and flexible connectivity. However, performance challenges arise as large circuits experience significant…

Quantum Physics · Physics 2026-01-19 Francisco Romão , Daniel Vonk , Emmanuil Giortamis , Dennis Sprokholt , Pramod Bhatotia

Noise and errors are inevitable parts of any practical implementation of a quantum computer. As a result, large-scale quantum computation will require ways to detect and correct errors on quantum information. Here, we present such a quantum…

Variational quantum algorithms are suitable for use on noisy quantum systems. One of the most important use-cases is the quantum simulation of materials, using the variational quantum eigensolver (VQE). To optimize VQE performance, a…

Quantum Physics · Physics 2022-01-12 Waheeda Saib , Petros Wallden , Ismail Akhalwaya

Quantum annealing is a promising technique which leverages quantum mechanics to solve hard optimization problems. Considerable progress has been made in the development of a physical quantum annealer, motivating the study of methods to…

Quantum Physics · Physics 2017-04-21 Maritza Hernandez , Maliheh Aramon

Noise and imperfections are among the prevalent challenges in quantum software engineering for current NISQ systems. They will remain important in the post-NISQ area, as logical, error-corrected qubits will be based on software mechanisms.…

Quantum Physics · Physics 2025-09-17 Stefan Raimund Maschek , Jürgen Schwitalla , Maja Franz , Wolfgang Mauerer

Quantum machine learning, which involves running machine learning algorithms on quantum devices, has garnered significant attention in both academic and business circles. In this paper, we offer a comprehensive and unbiased review of the…

Quantum Physics · Physics 2024-10-21 Yunfei Wang , Junyu Liu

Quantum computing provides a powerful framework for tackling computational problems that are classically intractable. The goal of this paper is to explore the use of quantum computers for solving relevant problems in systems and control…

Systems and Control · Electrical Eng. & Systems 2025-12-23 Jan Schneider , Julian Berberich

Quantum computation and communication are important branches of quantum information science. However, noise in realistic quantum devices fundamentally limits the utility of these quantum technologies. A conventional approach towards…

Quantum Physics · Physics 2021-03-18 Kyungjoo Noh

Quantum computing (QC) is a new paradigm offering the potential of exponential speedups over classical computing for certain computational problems. Each additional qubit doubles the size of the computational state space available to a QC…

Quantum Physics · Physics 2021-03-22 Wei Tang , Teague Tomesh , Martin Suchara , Jeffrey Larson , Margaret Martonosi

This review is designed to introduce mathematicians and computational scientists to quantum computing (QC) through the lens of uncertainty quantification (UQ) by presenting a mathematically rigorous and accessible narrative for…

Quantum Physics · Physics 2026-03-30 Ryan Bennink , Olena Burkovska , Konstantin Pieper , Jorge Ramirez , Elaine Wong