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Biomedical Foundation Models (FMs) are rapidly transforming AI-enabled healthcare research and entering clinical validation. However, their susceptibility to learning non-biological technical features -- including variations in…

The predominant success of diffusion models in generative modeling has spurred significant interest in understanding their theoretical foundations. In this work, we propose a feature learning framework aimed at analyzing and comparing the…

Machine Learning · Statistics 2025-03-04 Andi Han , Wei Huang , Yuan Cao , Difan Zou

The field of computational pathology has recently seen rapid advances driven by the development of modern vision foundation models (FMs), typically trained on vast collections of pathology images. Recent studies demonstrate that increasing…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Mikhail Karasikov , Joost van Doorn , Nicolas Känzig , Melis Erdal Cesur , Hugo Mark Horlings , Robert Berke , Fei Tang , Sebastian Otálora

Unsupervised feature learning often finds low-dimensional embeddings that capture the structure of complex data. For tasks for which prior expert topological knowledge is available, incorporating this into the learned representation may…

Machine Learning · Computer Science 2022-03-08 Robin Vandaele , Bo Kang , Jefrey Lijffijt , Tijl De Bie , Yvan Saeys

One of the fundamental tasks in understanding genomics is the problem of predicting Transcription Factor Binding Sites (TFBSs). With more than hundreds of Transcription Factors (TFs) as labels, genomic-sequence based TFBS prediction is a…

Machine Learning · Computer Science 2017-11-13 Jack Lanchantin , Arshdeep Sekhon , Ritambhara Singh , Yanjun Qi

Tabular foundation models, such as TabPFNv2 and TabICL, have recently dethroned gradient-boosted trees at the top of predictive benchmarks, demonstrating the value of in-context learning for tabular data. We introduce TabICLv2, a new…

Machine Learning · Computer Science 2026-02-12 Jingang Qu , David Holzmüller , Gaël Varoquaux , Marine Le Morvan

Deep neural networks have demonstrated remarkable performance in various vision tasks, but their success heavily depends on the quality of the training data. Noisy labels are a critical issue in medical datasets and can significantly…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Yeonguk Yu , Minhwan Ko , Sungho Shin , Kangmin Kim , Kyoobin Lee

Recent tabular Foundational Models (FM) such as TabPFN and TabICL, leverage in-context learning to achieve strong performance without gradient updates or fine-tuning. However, their robustness to adversarial manipulation remains largely…

Machine Learning · Computer Science 2026-04-10 Mohamed Djilani , Thibault Simonetto , Karim Tit , Florian Tambon , Salah Ghamizi , Maxime Cordy , Mike Papadakis

The recent popularity of foundation models and the pre-train-and-adapt paradigm, where a large-scale model is transferred to downstream tasks, is gaining attention for volumetric medical image segmentation. However, current transfer…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Julio Silva-Rodríguez , Jose Dolz , Ismail Ben Ayed

Mass spectrometry is the dominant technology in the field of proteomics, enabling high-throughput analysis of the protein content of complex biological samples. Due to the complexity of the instrumentation and resulting data, sophisticated…

TabPFN v2 achieves better results than tree-based models on several tabular benchmarks, which is notable since tree-based models are usually the strongest choice for tabular data. However, it cannot handle more than 10K context tokens…

Machine Learning · Computer Science 2025-09-18 Renat Sergazinov , Shao-An Yin

Large-scale general domain pretraining followed by downstream-specific finetuning has become a predominant paradigm in machine learning. However, discrepancies between the pretraining and target domains can still lead to performance…

Machine Learning · Computer Science 2024-10-15 Ruiyi Zhang , Sai Ashish Somayajula , Pengtao Xie

With the wide adoption of functional magnetic resonance imaging (fMRI) by cognitive neuroscience researchers, large volumes of brain imaging data have been accumulated in recent years. Aggregating these data to derive scientific insights…

Applications · Statistics 2020-06-01 Ming Bo Cai , Michael Shvartsman , Anqi Wu , Hejia Zhang , Xia Zhu

The significance of multi-scale features has been gradually recognized by the edge detection community. However, the fusion of multi-scale features increases the complexity of the model, which is not friendly to practical application. In…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Yachuan Li , Zongmin Li , Xavier Soria P. , Chaozhi Yang , Qian Xiao , Yun Bai , Hua Li , Xiangdong Wang

The early detection and prediction of cardiovascular diseases are crucial for reducing the severe morbidity and mortality associated with these conditions worldwide. A multi-headed self-attention mechanism, widely used in natural language…

Pathology foundation models (PFMs) have become central to computational pathology, aiming to offer general encoders for feature extraction from whole-slide images (WSIs). Despite strong benchmark performance, PFM robustness to real-world…

Image and Video Processing · Electrical Eng. & Systems 2026-01-08 Erik Thiringer , Fredrik K. Gustafsson , Kajsa Ledesma Eriksson , Mattias Rantalainen

Pathology foundation models (PFMs) have emerged as powerful tools for analyzing whole slide images (WSIs). However, adapting these pretrained PFMs for specific clinical tasks presents considerable challenges, primarily due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-06-06 Neeraj Kumar , Swaraj Nanda , Siddharth Singi , Jamal Benhamida , David Kim , Jie-Fu Chen , Amir Momeni-Boroujeni , Gregory M. Goldgof , Gabriele Campanella , Chad Vanderbilt

In medical contexts, the imbalanced data distribution in long-tailed datasets, due to scarce labels for rare diseases, greatly impairs the diagnostic accuracy of deep learning models. Recent multimodal text-image supervised foundation…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Sirui Li , Li Lin , Yijin Huang , Pujin Cheng , Xiaoying Tang

The increase of available large clinical and experimental datasets has contributed to a substantial amount of important contributions in the area of biomedical image analysis. Image segmentation, which is crucial for any quantitative…

Computer Vision and Pattern Recognition · Computer Science 2022-03-29 Nikhil Kumar Tomar , Debesh Jha , Michael A. Riegler , Håvard D. Johansen , Dag Johansen , Jens Rittscher , Pål Halvorsen , Sharib Ali

Machine learning approaches have become popular for molecular modeling tasks, including molecular force fields and properties prediction. Traditional supervised learning methods suffer from scarcity of labeled data for particular tasks,…

Chemical Physics · Physics 2022-11-29 Xiang Gao , Weihao Gao , Wenzhi Xiao , Zhirui Wang , Chong Wang , Liang Xiang