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Prior-Fitted Networks (PFNs) amortize Bayesian prediction by meta-learning over a synthetic task prior, but their standard output is a posterior predictive distribution over noisy observations. For sequential decision-making, such as active…

Machine Learning · Statistics 2026-05-08 Richard Bergna , Stefan Depeweg , José Miguel Hernández-Lobato

We present a novel graphical framework for modeling non-negative sequential data with hierarchical structure. Our model corresponds to a network of coupled non-negative matrix factorization (NMF) modules, which we refer to as a positive…

Machine Learning · Computer Science 2009-07-16 Brian K. Vogel

Training neural networks on randomly generated artificial datasets yields Bayesian models that capture the prior defined by the dataset-generating distribution. Prior-data Fitted Networks (PFNs) are a class of methods designed to leverage…

Machine Learning · Computer Science 2025-06-02 Samuel Müller , Arik Reuter , Noah Hollmann , David Rügamer , Frank Hutter

Pathology foundation models (PFMs) have recently emerged as powerful pretrained encoders for computational pathology, enabling transfer learning across a wide range of downstream tasks. However, systematic comparisons of these models for…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Fredrik K. Gustafsson , Constance Boissin , Johan Vallon-Christersson , David A. Clifton , Mattias Rantalainen

Tabular data, owing to its ubiquitous presence in real-world domains, has garnered significant attention in machine learning research. While tree-based models have long dominated tabular machine learning tasks, the recently proposed deep…

Machine Learning · Computer Science 2025-05-23 Zi-Jian Cheng , Zi-Yi Jia , Zhi Zhou , Yu-Feng Li , Lan-Zhe Guo

Machine learning (ML) systems are utilized in critical sectors, such as healthcare, law enforcement, and finance. However, these systems are often trained on historical data that contains demographic biases, leading to ML decisions that…

Machine Learning · Computer Science 2025-06-10 Jake Robertson , Noah Hollmann , Samuel Müller , Noor Awad , Frank Hutter

Foundation models, often pre-trained with large-scale data, have achieved paramount success in jump-starting various vision and language applications. Recent advances further enable adapting foundation models in downstream tasks efficiently…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Dequan Wang , Xiaosong Wang , Lilong Wang , Mengzhang Li , Qian Da , Xiaoqiang Liu , Xiangyu Gao , Jun Shen , Junjun He , Tian Shen , Qi Duan , Jie Zhao , Kang Li , Yu Qiao , Shaoting Zhang

Feature selection is essential for high-dimensional biomedical data, enabling stronger predictive performance, reduced computational cost, and improved interpretability in precision medicine applications. Existing approaches face notable…

Machine Learning · Computer Science 2026-01-07 Xiaoyan Sun , Qingyu Meng , Yalu Wen

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

Existing fine-tuning methods either tune all parameters of the pre-trained model (full fine-tuning), which is not efficient, or only tune the last linear layer (linear probing), which suffers a significant accuracy drop compared to the full…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Dongze Lian , Daquan Zhou , Jiashi Feng , Xinchao Wang

Mitotic figures are classified into typical and atypical variants, with atypical counts correlating strongly with tumor aggressiveness. Accurate differentiation is therefore essential for patient prognostication and resource allocation, yet…

Image and Video Processing · Electrical Eng. & Systems 2025-09-19 Mieko Ochi , Bae Yuan

Despite progress, deep neural networks still suffer performance declines under distribution shifts between training and test domains, leading to a substantial decrease in Quality of Experience (QoE) for applications. Existing test-time…

Machine Learning · Computer Science 2025-06-10 Qinting Jiang , Chuyang Ye , Dongyan Wei , Bingli Wang , Yuan Xue , Jingyan Jiang , Zhi Wang

Over the past decades, computer-aided diagnosis tools for breast cancer have been developed to enhance screening procedures, yet their clinical adoption remains challenged by data variability and inherent biases. Although foundation models…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Elodie Germani , Ilayda Selin Türk , Fatima Zeineddine , Charbel Mourad , Shadi Albarqouni

Bioinformatics has witnessed a paradigm shift with the increasing integration of artificial intelligence (AI), particularly through the adoption of foundation models (FMs). These AI techniques have rapidly advanced, addressing historical…

Quantitative Methods · Quantitative Biology 2024-02-08 Qing Li , Zhihang Hu , Yixuan Wang , Lei Li , Yimin Fan , Irwin King , Le Song , Yu Li

Leveraging the in-context learning (ICL) capability of Large Language Models (LLMs) for tabular classification has gained significant attention for its training-free adaptability across diverse datasets. Recent advancements, like TabPFN,…

Machine Learning · Computer Science 2025-06-09 Yuchen Zeng , Tuan Dinh , Wonjun Kang , Andreas C Mueller

In-context learners like TabPFN are promising for biomolecule efficacy prediction, where established molecular feature sets and relevant experimental results can serve as powerful contextual examples. However, their performance is highly…

Machine Learning · Computer Science 2025-10-08 Jie Li , Andrew McCarthy , Zhizhuo Zhang , Stephen Young

Feature representations derived from models pre-trained on large-scale datasets have shown their generalizability on a variety of audio analysis tasks. Despite this generalizability, however, task-specific features can outperform if…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-13 Yun-Ning Hung , Alexander Lerch

Accurate prediction of conversion from Mild Cognitive Impairment (MCI) to Alzheimers Diseases (AD) is essential for early intervention, however, developing reliable conversion predictive models is difficult to develop due to limited…

Artificial Intelligence · Computer Science 2026-05-21 Brad Ye , Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

Tabular Foundation Models (TFMs) achieve state-of-the-art zero-shot accuracy on small tabular datasets by meta-learning over synthetic data-generating processes -- making them highly attractive for practitioners who cannot afford large…

Machine Learning · Computer Science 2026-04-29 Laure Berti-Equille

Foundation models have revolutionized the paradigm of digital pathology, as they leverage general-purpose features to emulate real-world pathological practices, enabling the quantitative analysis of critical histological patterns and the…

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