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Investigating conformational landscapes of proteins is a crucial way to understand their biological functions and properties. AlphaFlow stands out as a sequence-conditioned generative model that introduces flexibility into structure…

Machine Learning · Computer Science 2024-07-18 Shaoning Li , Mingyu Li , Yusong Wang , Xinheng He , Nanning Zheng , Jian Zhang , Pheng-Ann Heng

Atmospheric retrievals (AR) characterize exoplanets by estimating atmospheric parameters from observed light spectra, typically by framing the task as a Bayesian inference problem. However, traditional approaches such as nested sampling are…

Instrumentation and Methods for Astrophysics · Physics 2023-12-14 Timothy D. Gebhard , Jonas Wildberger , Maximilian Dax , Daniel Angerhausen , Sascha P. Quanz , Bernhard Schölkopf

Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction are extensively used to reveal structural information on macromolecular complexes. Aiming at the highest achievable resolution, state of the art electron…

Fluorescence microscopy is a widely used method among cell biologists for studying the localization and co-localization of fluorescent protein. For microbial cell biologists, these studies often include tedious and time-consuming manual…

Computer Vision and Pattern Recognition · Computer Science 2020-09-29 Jonathan Reiner , Guy Azran , Gal Hyams

The Auto-ICell system, a novel, and cost-effective integrated droplet microfluidic system, is introduced for real-time analysis of single-cell morphology and apoptosis. This system integrates a 3D-printed microfluidic chip with image…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Yuanyuan Wei , Meiai Lin , Shanhang Luo , Syed Muhammad Tariq Abbasi , Liwei Tan , Guangyao Cheng , Bijie Bai , Yi-Ping Ho , Scott Wu Yuan , Ho-Pui Ho

We present a fast and accurate analytical method for fluorescence lifetime imaging microscopy (FLIM) using the extreme learning machine (ELM). We used extensive metrics to evaluate ELM and existing algorithms. First, we compared these…

Biological Physics · Physics 2022-03-28 Zhenya Zang , Dong Xiao , Quan Wang , Zinuo Li , Wujun Xie , Yu Chen , David Day Uei Li

A three-dimensional (3D) scanning velocimetry system is developed to quantify the 3D configurations of particles and their surrounding volumetric, three-component velocity fields. The approach uses a translating laser sheet to rapidly scan…

Fluid Dynamics · Physics 2021-08-04 Matt K. Fu , Isabel A. Houghton , John O. Dabiri

Photoemission orbital tomography provides direct access from laboratory measurements to the real-space molecular orbitals of well-ordered organic semiconductor layers. Specifically, the application of phase retrieval algorithms to…

Materials Science · Physics 2024-04-29 Thi Lan Dinh , G. S. Matthijs Jansen , D. Russell Luke , Wiebke Bennecke , Stefan Mathias

Investigating the dynamics of growing cell populations is crucial for unraveling key biological mechanisms in living organisms, with many important applications in therapeutics and biochemical engineering. Classical agent-based simulation…

Quantitative Methods · Quantitative Biology 2025-01-22 Shaoqing Chen , Zhou Fang , Zheng Hu , Da Zhou

Involved in mitotic condensation, interaction of transcriptional regulatory elements or isolation of structural domains, understanding loop formation is becoming a paradigm in the deciphering of chromatin architecture and its functional…

Quantitative Methods · Quantitative Biology 2024-09-17 Michaël Liefsoens , Timothy Földes , Maria Barbi

Event cameras are novel bio-inspired sensors that offer advantages over traditional cameras (low latency, high dynamic range, low power, etc.). Optical flow estimation methods that work on packets of events trade off speed for accuracy,…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Shintaro Shiba , Yoshimitsu Aoki , Guillermo Gallego

Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment in fields such as cardiology and ophthalmology. Such applications can be further facilitated by deep learning-based…

Medical Physics · Physics 2023-07-24 Xueshen Li , Zhenxing Dong , Hongshan Liu , Jennifer J. Kang-Mieler , Yuye Ling , Yu Gan

Ultrafast Electron Microscopy (UEM) has been demonstrated to be an effective table-top technique for imaging the temporally-evolving dynamics of matter with subparticle spatial resolution on the time scale of atomic motion. However, imaging…

Optics · Physics 2017-08-02 M. Th. Hassan , J. S. Baskin , B. Liao , A. H. Zewail

The absorption and emission of light by exoplanet atmospheres encode details of atmospheric composition, temperature, and dynamics. Fundamentally, simulating these processes requires detailed knowledge of the opacity of gases within an…

Instrumentation and Methods for Astrophysics · Physics 2024-08-07 Arjun B. Savel , Megan Bedell , Eliza M. -R. Kempton

Occlusions pose a significant challenge to optical flow algorithms that rely on local evidences. We consider an occluded point to be one that is imaged in the first frame but not in the next, a slight overloading of the standard definition…

Computer Vision and Pattern Recognition · Computer Science 2021-08-02 Shihao Jiang , Dylan Campbell , Yao Lu , Hongdong Li , Richard Hartley

Various microorganisms and some mammalian cells are able to swim in viscous fluids by performing nonreciprocal body deformations, such as rotating attached flagella or by distorting their entire body. In order to perform chemotaxis, i.e. to…

Biological Physics · Physics 2021-05-06 Benedikt Hartl , Maximilian Hübl , Gerhard Kahl , Andreas Zöttl

Learning to navigate to an image-specified goal is an important but challenging task for autonomous systems. The agent is required to reason the goal location from where a picture is shot. Existing methods try to solve this problem by…

Computer Vision and Pattern Recognition · Computer Science 2023-10-12 Xinyu Sun , Peihao Chen , Jugang Fan , Thomas H. Li , Jian Chen , Mingkui Tan

Crystal structure prediction is a long-standing challenge in materials science, with most data-driven methods developed for inorganic systems. This leaves an important gap for organic crystals, which are central to pharmaceuticals,…

Materials Science · Physics 2026-02-25 Mohammadmahdi Vahediahmar , Matthew A. McDonald , Feng Liu

Automatic detection and tracking of cells in microscopy images are major applications of computer vision technologies in both biomedical research and clinical practice. Though machine learning methods are increasingly common in these…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Nikomidisz Eftimiu , Michal Kozubek

Foam formation in Wastewater Treatment Plants (WTPs) is a major challenge that can reduce treatment efficiency and increase costs. The ability to automatically examine changes in real-time with respect to the percentage of foam can be of…

Computer Vision and Pattern Recognition · Computer Science 2025-11-13 Mehmet Batuhan Duman , Alejandro Carnero , Cristian Martín , Daniel Garrido , Manuel Díaz