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Significant progress has been made for estimating optical flow using deep neural networks. Advanced deep models achieve accurate flow estimation often with a considerable computation complexity and time-consuming training processes. In this…

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Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are…

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Increasing demand for understanding the vast heterogeneity of cellular phenotypes has driven the development of imaging flow cytometry (IFC), that combines features of flow cytometry with fluorescence and bright field microscopy. IFC…

Quantitative Methods · Quantitative Biology 2019-02-06 Yuanyuan Han , Rui Tang , Yi Gu , Alex Ce Zhang , Wei Cai , Violet Castor , Sung Hwan Cho , William Alaynick , Yu-Hwa Lo

We present a fast general-purpose algorithm for high-throughput clustering of data "with a two dimensional organization". The algorithm is designed to be implemented with FPGAs or custom electronics. The key feature is a processing time…

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Phylogenetics is a branch of computational biology that studies the evolutionary relationships among biological entities. Its long history and numerous applications notwithstanding, inference of phylogenetic trees from sequence data remains…

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Motivation: Cellular Electron CryoTomography (CECT) is an emerging 3D imaging technique that visualizes subcellular organization of single cells at submolecular resolution and in near-native state. CECT captures large numbers of…

Quantitative Methods · Quantitative Biology 2018-05-16 Yixiu Zhao , Xiangrui Zeng , Qiang Guo , Min Xu

Frequency-resolved optical gating (FROG) is probably the most popular technique for complete characterization of ultrashort laser pulses. In FROG, a reconstruction algorithm retrieves the pulse from a measured spectrogram, yet current FROG…

Optics · Physics 2019-06-11 Pavel Sidorenko , Oren Lahav , Zohar Avnat , Oren Cohen

Living creatures exhibit a remarkable diversity of locomotion mechanisms, evolving structures specialised for interacting with their environment. In the vast majority of cases, locomotor behaviours such as flying, crawling, and running, are…

Biological Physics · Physics 2020-07-28 Kirsty Y. Wan

Cytometry enables precise single-cell phenotyping within heterogeneous populations. These cell types are traditionally annotated via manual gating, but this method suffers from a lack of reproducibility and sensitivity to batch-effect.…

Lichens are symbiotic organisms composed of fungi, algae, and/or cyanobacteria that thrive in a variety of environments. They play important roles in carbon and nitrogen cycling, and contribute directly and indirectly to biodiversity.…

Computer Vision and Pattern Recognition · Computer Science 2023-10-27 Safwen Naimi , Olfa Koubaa , Wassim Bouachir , Guillaume-Alexandre Bilodeau , Gregory Jeddore , Patricia Baines , David Correia , Andre Arsenault

Cells control fluid flows with a spatial and temporal precision that far exceeds the capabilities of current microfluidic technologies. Cells achieve this superior spatio-temporal control by harnessing dynamic networks of cytoskeleton and…

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Morphological traits are physical characteristics of biological organisms that provide vital clues on how organisms interact with their environment. Yet extracting these traits remains a slow, expert-driven process, limiting their use in…

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In the realm of Artificial Intelligence Generated Content (AIGC), flow-matching models have emerged as a powerhouse, achieving success due to their robust theoretical underpinnings and solid ability for large-scale generative modeling.…

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Quantifying fish community structure is essential for understanding biodiversity and ecosystem responses in a changing environment, yet existing survey methods provide limited high-frequency, quantitative observations. Conventional…

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Inferring the root cause of failures among thousands of components in a data center network is challenging, especially for "gray" failures that are not reported directly by switches. Faults can be localized through end-to-end measurements,…

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While generative modeling has achieved remarkable success on tasks like natural language-conditioned image generation, enabling model adaptation from example data points remains a relatively underexplored and challenging problem. To this…

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Harmful algae blooms (HABs), which produce lethal toxins, are a growing global concern since they negatively affect the quality of drinking water and have major negative impact on wildlife, the fishing industry, as well as tourism and…

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Preventing fluid penetration poses a challenging reliability concern in the context of power electronics, which is usually caused by unforeseen microfractures along the sealing joints. A better and more reliable product design heavily…

Photoplethysmography (PPG) refers to the measurement of variations in blood volume using light and is a feature of most wearable devices. The PPG signals provide insight into the body's circulatory system and can be employed to extract…

Signal Processing · Electrical Eng. & Systems 2024-01-17 Yuyang Miao , Harry J. Davies , Danilo P. Mandic

Simulating in silico cellular responses to interventions is a promising direction to accelerate high-content image-based assays, critical for advancing drug discovery and gene editing. To support this, we introduce MorphGen, a…

Quantitative Methods · Quantitative Biology 2025-10-13 Berker Demirel , Marco Fumero , Theofanis Karaletsos , Francesco Locatello