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Analyzing microscopy images to extract biological object properties (e.g., their morphological organization, temporal dynamics, and population density) is fundamental to various biomedical research. Yet conducting this manually is costly…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Xiaofei Hui , Haoxuan Qu , Hossein Rahmani , Shuohong Wang , Jeff W. Lichtman , Jun Liu

Artificial Intelligence (AI) technology is based on theory and development of computer systems able to perform tasks that normally require human intelligence. In this context, deep learning is a family of computational methods that allow an…

Computers and Society · Computer Science 2019-05-17 Mario Coccia

Fluorescence microscopy, widely used in the study of living cells, tissues, and organisms, often faces the challenge of photodamage. This is primarily caused by the interaction between light and biochemical components during the imaging…

Quantitative Methods · Quantitative Biology 2024-04-01 Estibaliz Gómez-de-Mariscal , Mario Del Rosario , Joanna W Pylvänäinen , Guillaume Jacquemet , Ricardo Henriques

Single-photon LiDAR achieves high-precision 3D imaging in extreme environments through quantum-level photon detection technology. Current research primarily focuses on reconstructing 3D scenes from sparse photon events, whereas the semantic…

Image and Video Processing · Electrical Eng. & Systems 2025-05-09 Zili Zhang , Ziting Wen , Yiheng Qiang , Hongzhou Dong , Wenle Dong , Xinyang Li , Xiaofan Wang , Xiaoqiang Ren

(Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of devices due to its time-intensive…

Computer-aided design for synthetic biology promises to accelerate the rational and robust engineering of biological systems; it requires both detailed and quantitative mathematical and experimental models of the processes to (re)design,…

Realistic environments for prototyping, studying and improving analysis workflows are a crucial element on the way towards user-friendly physics analysis at HL-LHC scale. The IRIS-HEP Analysis Grand Challenge (AGC) provides such an…

High Energy Physics - Experiment · Physics 2024-01-08 Alexander Held , Elliott Kauffman , Oksana Shadura , Andrew Wightman

Accurate segmentation of lung cancer in pathology slides is a critical step in improving patient care. We proposed the ACDC@LungHP (Automatic Cancer Detection and Classification in Whole-slide Lung Histopathology) challenge for evaluating…

Single-cell RNA-sequencing (scRNA-seq) has become a routinely used technique to quantify the gene expression profile of thousands of single cells simultaneously. Analysis of scRNA-seq data plays an important role in the study of cell states…

Genomics · Quantitative Biology 2022-10-13 Matthew Brendel , Chang Su , Zilong Bai , Hao Zhang , Olivier Elemento , Fei Wang

Fully automatic deep learning has become the state-of-the-art technique for many tasks including image acquisition, analysis and interpretation, and for the extraction of clinically useful information for computer-aided detection,…

Machine Learning · Computer Science 2021-05-06 Samuel Budd , Emma C Robinson , Bernhard Kainz

The integration of Artificial Intelligence (AI) with High-Performance Computing (HPC) is transforming scientific workflows from human-directed pipelines into adaptive systems capable of autonomous decision-making. Large language models…

Deep learning has significantly advanced medical imaging analysis (MIA), achieving state-of-the-art performance across diverse clinical tasks. However, its success largely depends on large-scale, high-quality labeled datasets, which are…

Computer Vision and Pattern Recognition · Computer Science 2025-05-09 Cheng Jin , Zhengrui Guo , Yi Lin , Luyang Luo , Hao Chen

Generative artificial intelligence (AI) is rapidly transforming medical imaging by enabling capabilities such as data synthesis, image enhancement, modality translation, and spatiotemporal modeling. This review presents a comprehensive and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Xuanru Zhou , Cheng Li , Shuqiang Wang , Ye Li , Tao Tan , Hairong Zheng , Shanshan Wang

Quantitative analysis of multidimensional biological images is useful for understanding complex cellular phenotypes and accelerating advances in biomedical research. As modern microscopy generates ever-larger 2D and 3D datasets, existing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-17 Alexandr A. Kalinin , Anne E. Carpenter , Shantanu Singh , Matthew J. O'Meara

This article addresses the challenge of modeling the amplitude of spatially indexed low frequency fluctuations (ALFF) in resting state functional MRI as a function of cortical structural features and a multi-task coactivation network in the…

Methodology · Statistics 2026-02-09 Yeseul Jeon , Rajarshi Guhaniyogi , Aaron Scheffler

Medical image computing software is essential for identifying imaging biomarkers that can support diagnosis, prognosis, treatment planning, and clinical research. However, the lack of standardized, user-friendly, and reproducible software…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Mohammad Salmanpour , Mehrdad Oveisi , Isaac Shiri , Arman Rahmim

Increasingly, scientific discovery requires sophisticated and scalable workflows. Workflows have become the ``new applications,'' wherein multi-scale computing campaigns comprise multiple and heterogeneous executable tasks. In particular,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-26 Shantenu Jha , Vincent R. Pascuzzi , Matteo Turilli

Performance uncertainty quantification is essential for reliable validation and eventual clinical translation of medical imaging artificial intelligence (AI). Confidence intervals (CIs) play a central role in this process by indicating how…

Learning generalizable policies for robotic manipulation increasingly relies on large-scale models that map language instructions to actions (L2A). However, this one-way paradigm often produces policies that execute tasks without deeper…

Robotics · Computer Science 2026-05-25 Youngjin Hong , Houjian Yu , Mingen Li , Changhyun Choi

Over the past two decades, exponential growth in data availability, computational power, and newly available modeling techniques has led to an expansion in interest, investment, and research in Artificial Intelligence (AI) applications.…

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