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Brief Hospital Course (BHC) narratives must be clinically useful yet faithful to fragmented EHR evidence. LLM-based clinical summarizers still introduce unsupported statements, and alignment can encourage omissions ("say-less"…

Computation and Language · Computer Science 2026-03-12 Weixin Liu , Congning Ni , Qingyuan Song , Susannah L. Rose , Christopher Symons , Murat Kantarcioglu , Bradley A. Malin , Zhijun Yin

This study addresses the challenge of noise in training datasets for Direct Preference Optimization (DPO), a method for aligning Large Language Models (LLMs) with human preferences. We categorize noise into pointwise noise, which includes…

Machine Learning · Computer Science 2025-04-21 Junkang Wu , Yuexiang Xie , Zhengyi Yang , Jiancan Wu , Jiawei Chen , Jinyang Gao , Bolin Ding , Xiang Wang , Xiangnan He

Direct Preference Optimization (DPO) has emerged as a de-facto approach for aligning language models with human preferences. Recent work has shown DPO's effectiveness relies on training data quality. In particular, clear quality differences…

Machine Learning · Computer Science 2025-01-28 Nirav Diwan , Tolga Ergen , Dongsub Shim , Honglak Lee

Direct Preference Optimisation (DPO) is effective at significantly improving the performance of large language models (LLMs) on downstream tasks such as reasoning, summarisation, and alignment. Using pairs of preferred and dispreferred…

Computation and Language · Computer Science 2024-07-04 Arka Pal , Deep Karkhanis , Samuel Dooley , Manley Roberts , Siddartha Naidu , Colin White

Direct Preference Optimization (DPO), a standard method for aligning language models with human preferences, is traditionally applied to offline preferences. Recent studies show that DPO benefits from iterative training with online…

Computation and Language · Computer Science 2024-06-18 Jie Liu , Zhanhui Zhou , Jiaheng Liu , Xingyuan Bu , Chao Yang , Han-Sen Zhong , Wanli Ouyang

Large Language Model (LLM) fine tuning is underutilized in the field of medicine. Two of the most common methods of fine tuning are Supervised Fine Tuning (SFT) and Direct Preference Optimization (DPO), but there is little guidance…

Computation and Language · Computer Science 2024-12-16 Thomas Savage , Stephen Ma , Abdessalem Boukil , Vishwesh Patel , Ekanath Rangan , Ivan Lopez , Jonathan H Chen

The rapid progress in clinical data management systems and artificial intelligence approaches enable the era of personalized medicine. Intensive care units (ICUs) are the ideal clinical research environment for such development because they…

Computation and Language · Computer Science 2022-09-28 Thanh-Dung Le , Rita Noumeir , Jerome Rambaud , Guillaume Sans , Philippe Jouvet

Direct Preference Optimization (DPO) is an effective technique that leverages pairwise preference data (usually one chosen and rejected response pair per user prompt) to align LLMs to human preferences. In practice, multiple responses can…

Computation and Language · Computer Science 2024-11-11 Pulkit Pattnaik , Rishabh Maheshwary , Kelechi Ogueji , Vikas Yadav , Sathwik Tejaswi Madhusudhan

Direct Preference Optimization (DPO) have emerged as a popular method for aligning Large Language Models (LLMs) with human preferences. While DPO effectively preserves the relative ordering between chosen and rejected responses through…

Computation and Language · Computer Science 2025-06-05 Lin Sun , Chuang Liu , Peng Liu , Bingyang Li , Weijia Lu , Ning Wu

Aligning large language models (LLMs) is a central objective of post-training, often achieved through reward modeling and reinforcement learning methods. Among these, direct preference optimization (DPO) has emerged as a widely adopted…

Computation and Language · Computer Science 2026-03-03 Aladin Djuhera , Farhan Ahmed , Swanand Ravindra Kadhe , Syed Zawad , Heiko Ludwig , Holger Boche

Direct Preference Optimization (DPO) has become the de facto standard for offline preference alignment of large language models, but its reliance on a reference policy introduces a critical tension. DPO weighs each update relative to a…

Machine Learning · Computer Science 2026-02-13 Suqin Yuan , Xingrui Yu , Jiyang Zheng , Lei Feng , Dadong Wang , Ivor Tsang , Tongliang Liu

Direct Preference Optimization (DPO) is an effective framework for aligning large language models with human preferences, but it struggles with complex reasoning tasks. DPO optimizes for the likelihood of generating preferred over…

Artificial Intelligence · Computer Science 2026-04-23 Darsh Kachroo , Adriana Caraeni , Arjun Prasaath Anbazhagan , Brennan Lagasse , Kevin Zhu

Direct Preference Optimization (DPO) has emerged as a compelling approach for training Large Language Models (LLMs) to adhere to human preferences. However, the performance of DPO is sensitive to the fine-tuning of its trade-off parameter…

Artificial Intelligence · Computer Science 2024-10-15 Junkang Wu , Yuexiang Xie , Zhengyi Yang , Jiancan Wu , Jinyang Gao , Bolin Ding , Xiang Wang , Xiangnan He

General-purpose large language models (LLMs) have demonstrated remarkable generative and reasoning capabilities but remain limited in healthcare and caregiving applications due to two key deficiencies: factual unreliability and a lack of…

Computation and Language · Computer Science 2025-12-09 Emre Umucu , Guillermina Solis , Leon Garza , Emilia Rivas , Beatrice Lee , Anantaa Kotal , Aritran Piplai

Extractive question answering over clinical text is a crucial need to help deal with the deluge of clinical text generated in hospitals. While encoder models (e.g., BERT) have been popular for this reading comprehension task, recently…

Information Retrieval · Computer Science 2024-07-22 Md Sultan Al Nahian , Ramakanth Kavuluru

Direct Preference Optimization (DPO) simplifies reinforcement learning from human feedback (RLHF) for large language models (LLMs) by directly optimizing human preferences without an explicit reward model. We find that during DPO training,…

Computation and Language · Computer Science 2026-01-01 Junshu Pan , Wei Shen , Shulin Huang , Qiji Zhou , Yue Zhang

Aligning the output of Large Language Models (LLMs) with human preferences (e.g., by means of reinforcement learning with human feedback, or RLHF) is essential for ensuring their effectiveness in real-world scenarios. Despite significant…

Artificial Intelligence · Computer Science 2024-10-23 Pietro Bernardelle , Gianluca Demartini

Efficient preference optimization algorithms such as Direct Preference Optimization (DPO) have become a popular approach in aligning large language models (LLMs) with human preferences. These algorithms implicitly treat the LLM as a reward…

Computation and Language · Computer Science 2025-07-29 Tong Liu , Xiao Yu , Wenxuan Zhou , Jindong Gu , Volker Tresp

Large language models (LLMs) have shown remarkable performance across various tasks, yet their ability to handle long-context reading remains challenging. This study explores the effectiveness of leveraging high-quality academic peer review…

Computation and Language · Computer Science 2024-11-11 Shengzhi Li , Kittipat Kampa , Rongyu Lin , Bohang Li , Shichao Pei

Direct Preference Optimization (DPO) has emerged as a promising approach for aligning large language models with human preferences. While prior work mainly extends DPO from the aspect of the objective function, we instead improve DPO from…

Machine Learning · Computer Science 2026-02-17 Xun Deng , Han Zhong , Rui Ai , Fuli Feng , Zheng Wang , Xiangnan He
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