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Miscalibrated confidence scores are a practical obstacle to deploying AI in clinical settings. A model that is always overconfident offers no useful signal for deferral. We present a multi-agent framework that combines domain-specific…

Artificial Intelligence · Computer Science 2026-03-26 John Ray B. Martinez

Trustworthy biomedical question answering (QA) systems must not only provide accurate answers but also justify them with current, verifiable evidence. Retrieval-augmented approaches partially address this gap but lack mechanisms to…

Computation and Language · Computer Science 2026-03-31 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Diagnosing hepatic diseases accurately and interpretably is critical, yet it remains challenging in real-world clinical settings. Existing AI approaches for clinical diagnosis often lack transparency, structured reasoning, and…

Artificial Intelligence · Computer Science 2026-03-06 Zheng Li , Jiayi Xu , Zhikai Hu , Hechang Chen , Lele Cong , Yunyun Wang , Shuchao Pang

Recent advances in the intrinsic reasoning capabilities of large language models (LLMs) have given rise to LLM-based agent systems that exhibit near-human performance on a variety of automated tasks. However, although these systems share…

Artificial Intelligence · Computer Science 2025-08-26 Bingxi Zhao , Lin Geng Foo , Ping Hu , Christian Theobalt , Hossein Rahmani , Jun Liu

This work discusses how to build more rational language and multimodal agents and what criteria define rationality in intelligent systems. Rationality is the quality of being guided by reason, characterized by decision-making that aligns…

Artificial Intelligence · Computer Science 2025-02-18 Bowen Jiang , Yangxinyu Xie , Xiaomeng Wang , Yuan Yuan , Zhuoqun Hao , Xinyi Bai , Weijie J. Su , Camillo J. Taylor , Tanwi Mallick

Large language models (LLMs) are catalyzing the development of autonomous AI research agents for scientific and engineering discovery. We present FM Agent, a novel and general-purpose multi-agent framework that leverages a synergistic…

Multi-agent large language model frameworks are promising for complex multi step reasoning, yet existing systems remain weak for scientific and knowledge intensive domains due to static prompts and agent roles, rigid workflows, and…

Artificial Intelligence · Computer Science 2026-03-04 Yichao Feng , Haoran Luo , Zhenghong Lin , Yiqun Sun , Pengfei Wei , Lawrence B. Hsieh , Anh Tuan Luu

Multi-agent AI systems powered by large language models (LLMs) are increasingly applied to solve complex tasks. However, these systems often rely on fragile, manually designed prompts and heuristics, making optimization difficult. A key…

Artificial Intelligence · Computer Science 2025-02-10 Wanjia Zhao , Mert Yuksekgonul , Shirley Wu , James Zou

Financial fraud detection in real-world scenarios presents significant challenges due to the subtlety and dispersion of evidence across complex, multi-year financial disclosures. In this work, we introduce a novel multi-agent reasoning…

Artificial Intelligence · Computer Science 2025-10-02 Songran Bai , Bingzhe Wu , Yiwei Zhang , Chengke Wu , Xiaolong Zheng , Yaze Yuan , Ke Wu , Jianqiang Li

Large Language Models (LLMs) have enabled multi-agent systems to perform autonomous code generation for complex tasks. Despite the recent growth in research and industrial applications in this area, there is little work on synthesizing…

Software Engineering · Computer Science 2026-04-21 Zeeshan Rasheeda , Muhammad Waseema , Kai-Kristian Kemella , Mika Saari , Pekka Abrahamsson

In healthcare intelligence, the ability to fuse heterogeneous, multi-intent information from diverse clinical sources is fundamental to building reliable decision-making systems. Large Language Model (LLM)-driven information interaction…

Computation and Language · Computer Science 2025-07-04 Dingkang Yang , Jinjie Wei , Mingcheng Li , Jiyao Liu , Lihao Liu , Ming Hu , Junjun He , Yakun Ju , Wei Zhou , Yang Liu , Lihua Zhang

Translational medicine turns underspecified development goals into evidence synthesis that must combine literature, trials, patents, and quantitative multi-omics analysis while preserving identifiers, uncertainty, and retrievable…

Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by…

Human-Computer Interaction · Computer Science 2026-03-31 Peng Kuai , Yukun Yang , Shaolun Ruan , Junchi Xu , Yanjie Zhang , Lin Zhang , Min Zhu , Rui Sheng

Verification of biomedical claims is critical for healthcare decision-making, public health policy and scientific research. We present an interactive biomedical claim verification system by integrating LLMs, transparent model explanations,…

Human-Computer Interaction · Computer Science 2025-03-03 Siting Liang , Daniel Sonntag

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Large Language Models (LLMs) have demonstrated remarkable capabilities in various reasoning and generation tasks. However, their proficiency in complex causal reasoning, discovery, and estimation remains an area of active development, often…

Artificial Intelligence · Computer Science 2025-09-03 Adib Bazgir , Amir Habibdoust , Yuwen Zhang , Xing Song

Artificial intelligence is reshaping scientific exploration, but most methods automate procedural tasks without engaging in scientific reasoning, limiting autonomy in discovery. We introduce Materials Agents for Simulation and Theory in…

Recent multi-agent frameworks have broadened the ability to tackle oncology decision support tasks that require reasoning over dynamic, heterogeneous patient data. We propose Contribution-Aware Medical Multi-Agents (CoMMa), a decentralized…

Artificial Intelligence · Computer Science 2026-02-11 Yichen Wu , Yujin Oh , Sangjoon Park , Kailong Fan , Dania Daye , Hana Farzaneh , Xiang Li , Raul Uppot , Quanzheng Li

Large Language Models (LLMs) have shown remarkable reasoning capabilities in mathematical and scientific tasks. To enhance complex reasoning, multi-agent systems have been proposed to harness the collective intelligence of LLM agents.…

Artificial Intelligence · Computer Science 2025-10-22 Zhenyu Bi , Meng Lu , Yang Li , Swastik Roy , Weijie Guan , Morteza Ziyadi , Xuan Wang

Recent advancements in LLMs indicate potential for novel applications, as evidenced by the reasoning capabilities in the latest OpenAI and DeepSeek models. To apply these models to domain-specific applications beyond text generation,…

Cryptography and Security · Computer Science 2025-07-22 Felix Härer