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Functional magnetic resonance imaging (fMRI) data have become increasingly available and are useful for describing functional connectivity (FC), the relatedness of neuronal activity in regions of the brain. This FC of the brain provides…

Machine Learning · Statistics 2020-10-14 Andrew DiLernia , Karina Quevedo , Jazmin Camchong , Kelvin Lim , Wei Pan , Lin Zhang

Building comprehensive brain connectomes has proved of fundamental importance in resting-state fMRI (rs-fMRI) analysis. Based on the foundation of brain network, spatial-temporal-based graph convolutional networks have dramatically improved…

Machine Learning · Computer Science 2023-12-19 Rui Yang , Wenrui Dai , Huajun She , Yiping P. Du , Dapeng Wu , Hongkai Xiong

Finding an appropriate representation of dynamic activities in the brain is crucial for many downstream applications. Due to its highly dynamic nature, temporally averaged fMRI (functional magnetic resonance imaging) can only provide a…

Machine Learning · Computer Science 2022-08-18 Sikun Lin , Shuyun Tang , Scott Grafton , Ambuj Singh

This paper describes an approach of using dynamic Structural Equation Modeling (SEM) analysis to estimate the connectivity networks from resting-state fMRI data measured by a multiband EPI sequence. Two structural equation models were…

Neurons and Cognition · Quantitative Biology 2017-04-03 Jiancheng Zhuang

In this study, we explore the fundamental principles behind the architecture of the human brain's structural connectome, from the perspective of spectral analysis of Laplacian and adjacency matrices. Building on the idea that the brain…

Neurons and Cognition · Quantitative Biology 2024-05-28 Anna Bobyleva , Alexander Gorsky , Sergei Nechaev , Olga Valba , Nikita Pospelov

The brain is often studied from a network perspective, where functional activity is assessed using functional Magnetic Resonance Imaging (fMRI) to estimate connectivity between predefined neuronal regions. Functional connectivity can be…

Applications · Statistics 2025-07-22 Olivier Bisson , Yanis Aeschlimann , Samuel Deslauriers-Gauthier , Xavier Pennec

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

Modeling the behavior of coupled networks is challenging due to their intricate dynamics. For example in neuroscience, it is of critical importance to understand the relationship between the functional neural processes and anatomical…

Machine Learning · Computer Science 2021-04-20 Hongyuan You , Sikun Lin , Ambuj K. Singh

A major challenge in neuroscience is posed by the need for relating the emerging dynamical features of brain activity with the underlying modular structure of neural connections, hierarchically organized throughout several scales. The…

Neurons and Cognition · Quantitative Biology 2016-06-03 Pablo Villegas , Jorge Hidalgo , Paolo Moretti , Miguel A. Muñoz

We propose a method for estimating more reproducible functional networks that are more strongly associated with dynamic task activity by using recurrent neural networks with long short term memory (LSTMs). The LSTM model is trained in an…

Quantitative Methods · Quantitative Biology 2021-05-07 Nicha C. Dvornek , Pamela Ventola , James S. Duncan

The human brain is highly adaptive: its functional connectivity reconfigures on multiple timescales during cognition and learning, enabling flexible information processing. By contrast, artificial neural networks typically rely on…

Neural and Evolutionary Computing · Computer Science 2025-10-29 Peilin He , Tananun Songdechakraiwut

The estimation of sparse hierarchical components reflecting patterns of the brain's functional connectivity from rsfMRI data can contribute to our understanding of the brain's functional organization, and can lead to biomarkers of diseases.…

Machine Learning · Computer Science 2021-04-22 Dushyant Sahoo , Christos Davatzikos

Understanding the relationship between the structure and function of the human brain is one of the most important open questions in Neurosciences. In particular, Resting State Networks (RSN) and more specifically the Default Mode Network…

Neurons and Cognition · Quantitative Biology 2019-06-14 Julio A. Peraza-Goicolea , Eduardo Martínez-Montes , Eduardo Aubert , Pedro A. Valdés-Hernández , Roberto Mulet

We aimed to explore the capability of deep learning to approximate the function instantiated by biological neural circuits-the functional connectome. Using deep neural networks, we performed supervised learning with firing rate observations…

Neurons and Cognition · Quantitative Biology 2022-11-24 Sihao Liu , Augustine N Mavor-Parker , Caswell Barry

Brain network analysis is a useful approach to studying human brain disorders because it can distinguish patients from healthy people by detecting abnormal connections. Due to the complementary information from multiple modal neuroimages,…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Qiankun Zuo , Yanfei Zhu , Libin Lu , Zhi Yang , Yuhui Li , Ning Zhang

Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…

Neurons and Cognition · Quantitative Biology 2011-05-09 Paul Expert , Renaud Lambiotte , Dante R. Chialvo , Kim Christensen , Henrik Jeldtoft Jensen , David J. Sharp , Federico Turkheimer

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

Neurons and Cognition · Quantitative Biology 2023-08-24 Yihan Wu , Lana Vasung , Camilo Calixto , Ali Gholipour , Davood Karimi

The white matter of the brain is organised into axonal bundles that support long-range neural communication. Although diffusion MRI (dMRI) enables detailed mapping of these pathways through tractography, how white matter pathways directly…

Neurons and Cognition · Quantitative Biology 2026-02-24 Yifei Sun , James M. Shine , Robert D. Sanders , Robin F. H. Cash , Sharon L. Naismith , Fernando Calamante , Jinglei Lv

Little is currently known about the coordination of neural activity over longitudinal time-scales and how these changes relate to behavior. To investigate this issue, we used resting-state fMRI data from a single individual to identify the…

Neurons and Cognition · Quantitative Biology 2017-05-30 James M. Shine , Oluwasanmi Koyejo , Russell A. Poldrack

Current functional Magnetic Resonance Imaging technology is able to resolve billions of individual functional connections characterizing the human connectome. Classical statistical inferential procedures attempting to make valid inferences…

Quantitative Methods · Quantitative Biology 2023-01-11 Alfonso Nieto-Castanon