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Related papers: DeepAf: One-Shot Spatiospectral Auto-Focus Model f…

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Autofocus (AF) methods are extensively used in biomicroscopy, for example to acquire timelapses, where the imaged objects tend to drift out of focus. AD algorithms determine an optimal distance by which to move the sample back into the…

Image and Video Processing · Electrical Eng. & Systems 2021-01-14 Adrian Shajkofci , Michael Liebling

Whole slide imaging (WSI) has moved digital pathology closer to diagnostic practice in recent years. Due to the inherent tissue topography variability, accurate autofocusing remains a critical challenge for WSI and automated microscopy…

Digital pathology enables remote access or consults and powerful image analysis algorithms. However, the slide digitization process can create artifacts such as out-of-focus (OOF). OOF is often only detected upon careful review, potentially…

Computer Vision and Pattern Recognition · Computer Science 2020-06-03 Timo Kohlberger , Yun Liu , Melissa Moran , Po-Hsuan , Chen , Trissia Brown , Craig H. Mermel , Jason D. Hipp , Martin C. Stumpe

In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Seyed Kahaki , Alexander R. Webber , Ghada Zamzmi , Adarsh Subbaswamy , Rucha Deshpande , Aldo Badano

Breast cancer diagnosis demands rapid and precise tools, yet traditional histopathological methods often fall short in intra-operative settings. Deep Ultraviolet (DUV) fluorescence imaging emerges as a transformative approach, offering…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Nagur Shareef Shaik , Teja Krishna Cherukuri , Dong Hye Ye

Whole slide imaging (WSI) is an emerging technology for digital pathology. The process of autofocusing is the main influence of the performance of WSI. Traditional autofocusing methods either are time-consuming due to repetitive mechanical…

Image and Video Processing · Electrical Eng. & Systems 2020-03-17 Qiang Li , Xianming Liu , Kaige Han , Cheng Guo , Xiangyang Ji , Xiaolin Wu

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

The scarcity of annotated surgical data poses a significant challenge for developing deep learning systems in computer-assisted interventions. While diffusion models can synthesize realistic images, they often suffer from data memorization,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Danush Kumar Venkatesh , Stefanie Speidel

Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Tarun G , Naman Malpani , Gugan Thoppe , Sridharan Devarajan

Automation in optical microscopy is critical for enabling high-throughput imaging across a wide range of biomedical applications. Among the essential components of automated systems, robust autofocusing plays a pivotal role in maintaining…

One of the main obstacles of adopting digital pathology is the challenge of efficient processing of hyperdimensional digitized biopsy samples, called whole slide images (WSIs). Exploiting deep learning and introducing compact WSI…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Azam Asilian Bidgoli , Shahryar Rahnamayan , Taher Dehkharghanian , Abtin Riasatian , H. R. Tizhoosh

Autofocus is necessary for high-throughput and real-time scanning in microscopic imaging. Traditional methods rely on complex hardware or iterative hill-climbing algorithms. Recent learning-based approaches have demonstrated remarkable…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Yongping Zhai , Xiaoxi Fu , Qiang Su , Jia Hu , Yake Zhang , Yunfeng Zhou , Chaofan Zhang , Xiao Li , Wenxin Wang , Dongdong Wu , Shen Yan

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Histopathological images contain abundant phenotypic information and pathological patterns, which are the gold standards for disease diagnosis and essential for the prediction of patient prognosis and treatment outcome. In recent years,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-26 Linhao Qu , Siyu Liu , Xiaoyu Liu , Manning Wang , Zhijian Song

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Pathology images are considered the ``gold standard" for cancer diagnosis and treatment, with gigapixel images providing extensive tissue and cellular information. Existing methods fail to simultaneously extract global structural and local…

Computer Vision and Pattern Recognition · Computer Science 2025-02-17 Haoming Luo , Xiaotian Yu , Shengxuming Zhang , Jiabin Xia , Yang Jian , Yuning Sun , Liang Xue , Mingli Song , Jing Zhang , Xiuming Zhang , Zunlei Feng

Quality assurance is a critical but underexplored area in digital pathology, where even minor artifacts can have significant effects. Artifacts have been shown to negatively impact the performance of AI diagnostic models. In current…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Meredith VandeHaar , M. Clinch , I. Yilmaz , M. A. Rahman , Y. Xiao , F. Dogany , H. M. Alazab , A. Nassar , Z. Akkus , B. Dangott

Supervised deep learning methods have achieved considerable success in medical image analysis, owing to the availability of large-scale and well-annotated datasets. However, creating such datasets for whole slide images (WSIs) in…

Computer Vision and Pattern Recognition · Computer Science 2024-06-10 Hao Wang , Euijoon Ahn , Jinman Kim

The AI-based assisted diagnosis programs have been widely investigated on medical ultrasound images. Complex scenario of ultrasound image, in which the coupled interference of internal and external factors is severe, brings a unique…

Image and Video Processing · Electrical Eng. & Systems 2025-10-15 Gongping Chen , Lei Zhao , Xiaotao Yin , Liang Cui , Jianxun Zhang , Yu Dai , Ningning Liu

Whole Slide Images (WSIs) play a crucial role in accurate cancer diagnosis and prognosis, as they provide tissue details at the cellular level. However, the rapid growth of computational tasks involving WSIs poses significant challenges.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Khang Nguyen , Yasuhiko Nakashima
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