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Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst

While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation…

Computation and Language · Computer Science 2024-02-26 Guangzhi Xiong , Qiao Jin , Zhiyong Lu , Aidong Zhang

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

The recent mainstream adoption of large language model (LLM) technology is enabling novel applications in the form of chatbots and virtual assistants across many domains. With the aim of grounding LLMs in trusted domains and avoiding the…

Computation and Language · Computer Science 2025-07-08 Antoine Nzeyimana , Andre Niyongabo Rubungo

Retrieval-Augmented Generation (RAG) offers a well-established path to grounding large language model (LLM) outputs in external knowledge, yet the question of which retrieval strategy works best in a high-stakes domain such as biomedicine…

Computation and Language · Computer Science 2026-05-05 Devi Prasad Bal , Subhashree Puhan

Retrieval-Augmented Generation (RAG) is essential for integrating external knowledge into Large Language Model (LLM) outputs. While the literature on RAG is growing, it primarily focuses on systematic reviews and comparisons of new…

Computation and Language · Computer Science 2024-04-02 Matouš Eibich , Shivay Nagpal , Alexander Fred-Ojala

Retrieval-Augmented Generation (RAG) has recently demonstrated the performance of Large Language Models (LLMs) in the knowledge-intensive tasks such as Question-Answering (QA). RAG expands the query context by incorporating external…

Machine Learning · Computer Science 2024-06-18 Zijian Hei , Weiling Liu , Wenjie Ou , Juyi Qiao , Junming Jiao , Guowen Song , Ting Tian , Yi Lin

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

In the rapidly changing world of smart technology, searching for documents has become more challenging due to the rise of advanced language models. These models sometimes face difficulties, like providing inaccurate information, commonly…

Information Retrieval · Computer Science 2025-03-20 Julien Pierre Edmond Ghali , Kosuke Shima , Koichi Moriyama , Atsuko Mutoh , Nobuhiro Inuzuka

The emergent abilities of large language models (LLMs) have demonstrated great potential in solving medical questions. They can possess considerable medical knowledge, but may still hallucinate and are inflexible in the knowledge updates.…

Computation and Language · Computer Science 2024-10-14 Guangzhi Xiong , Qiao Jin , Xiao Wang , Minjia Zhang , Zhiyong Lu , Aidong Zhang

Retrieval-Augmented Generation (RAG) has been shown to enhance the factual accuracy of Large Language Models (LLMs), but existing methods often suffer from limited reasoning capabilities in effectively using the retrieved evidence,…

Computation and Language · Computer Science 2024-10-03 Shayekh Bin Islam , Md Asib Rahman , K S M Tozammel Hossain , Enamul Hoque , Shafiq Joty , Md Rizwan Parvez

Large Language Models (LLMs) have enabled a wide range of applications through their powerful capabilities in language understanding and generation. However, as LLMs are trained on static corpora, they face difficulties in addressing…

Computation and Language · Computer Science 2025-10-13 Yongjie Wang , Yue Yu , Kaisong Song , Jun Lin , Zhiqi Shen

Large language models (LLMs) have demonstrated strong capabilities in medical question answering; however, purely parametric models often suffer from knowledge gaps and limited factual grounding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2026-04-09 Nusrat Sultana , Abdullah Muhammad Moosa , Kazi Afzalur Rahman , Sajal Chandra Banik

Large language models (LLMs) often generate outdated or inaccurate information based on static training datasets. Retrieval-augmented generation (RAG) mitigates this by integrating outside data sources. While previous RAG systems used…

Given the growing trend of many organizations integrating Retrieval Augmented Generation (RAG) into their operations, we assess RAG on domain-specific data and test state-of-the-art models across various optimization techniques. We…

Artificial Intelligence · Computer Science 2024-11-14 Anum Afzal , Juraj Vladika , Gentrit Fazlija , Andrei Staradubets , Florian Matthes

Despite their remarkable capabilities, large language models (LLMs) often produce responses containing factual inaccuracies due to their sole reliance on the parametric knowledge they encapsulate. Retrieval-Augmented Generation (RAG), an ad…

Computation and Language · Computer Science 2023-10-19 Akari Asai , Zeqiu Wu , Yizhong Wang , Avirup Sil , Hannaneh Hajishirzi

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by incorporating external knowledge to generate a response within a context with improved accuracy and reduced hallucinations. However, multi-modal RAG systems face…

Machine Learning · Computer Science 2025-01-09 Matin Mortaheb , Mohammad A. Amir Khojastepour , Srimat T. Chakradhar , Sennur Ulukus

Large language models (LLMs) are very costly and inefficient to update with new information. To address this limitation, retrieval-augmented generation (RAG) has been proposed as a solution that dynamically incorporates external knowledge…

Computation and Language · Computer Science 2025-07-10 Sezen Perçin , Xin Su , Qutub Sha Syed , Phillip Howard , Aleksei Kuvshinov , Leo Schwinn , Kay-Ulrich Scholl
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