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Large Language Models (LLMs) are increasingly deployed in healthcare, yet their communicative alignment with clinical standards remains insufficiently quantified. We conduct a multidimensional evaluation of general-purpose and…

Computation and Language · Computer Science 2026-04-23 Mariano Barone , Francesco Di Serio , Roberto Moio , Marco Postiglione , Giuseppe Riccio , Antonio Romano , Vincenzo Moscato

Psychological assessment tools have long helped humans understand behavioural patterns. While Large Language Models (LLMs) can generate content comparable to that of humans, we explore whether they exhibit personality traits. To this end,…

Computation and Language · Computer Science 2025-02-11 Pranav Bhandari , Usman Naseem , Amitava Datta , Nicolas Fay , Mehwish Nasim

Psychological constructs within individuals are widely believed to be interconnected. We investigated whether and how Large Language Models (LLMs) can model the correlational structure of human psychological traits from minimal quantitative…

Artificial Intelligence · Computer Science 2026-03-24 Yi-Fei Liu , Yi-Long Lu , Di He , Hang Zhang

Large language models (LLMs) have shown considerable potential in supporting medical diagnosis. However, their effective integration into clinical workflows is hindered by physicians' difficulties in perceiving and trusting LLM…

Human-Computer Interaction · Computer Science 2026-01-28 Yuansong Xu , Yichao Zhu , Haokai Wang , Yuchen Wu , Yang Ouyang , Hanlu Li , Wenzhe Zhou , Xinyu Liu , Chang Jiang , Quan Li

Despite the many use cases for large language models (LLMs) in creating personalized chatbots, there has been limited research on evaluating the extent to which the behaviors of personalized LLMs accurately and consistently reflect specific…

Computation and Language · Computer Science 2024-04-03 Hang Jiang , Xiajie Zhang , Xubo Cao , Cynthia Breazeal , Deb Roy , Jad Kabbara

A growing body of research examines personality traits in Large Language Models (LLMs), particularly in human-agent collaboration. Prior work has frequently applied the Big Five inventory to assess LLM behavior analogous to human…

Human-Computer Interaction · Computer Science 2026-03-20 Kim Zierahn , Cristina Cachero , Anna Korhonen , Nuria Oliver

Psychotherapy is a primary treatment for many mental health conditions, yet the interplay among therapist behaviors, client responses, and the therapeutic relationship remains difficult to untangle. This work advances a computational…

Computers and Society · Computer Science 2026-02-16 Angela Chen , Siwei Jin , Canwen Wang , Holly Swartz , Tongshuang Wu , Robert E Kraut , Haiyi Zhu

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

Machine Learning · Computer Science 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

The integration of Large Language Models (LLMs) into the healthcare domain has the potential to significantly enhance patient care and support through the development of empathetic, patient-facing chatbots. This study investigates an…

Computation and Language · Computer Science 2024-05-28 Man Luo , Christopher J. Warren , Lu Cheng , Haidar M. Abdul-Muhsin , Imon Banerjee

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes

Large language models (LLMs) often match or exceed clinician-level performance on medical benchmarks, yet very few are evaluated on real clinical data or examined beyond headline metrics. We present, to our knowledge, the first evaluation…

Large Language Models (LLMs) have demonstrated surprising performance across various natural language processing tasks. Recently, medical LLMs enhanced with domain-specific knowledge have exhibited excellent capabilities in medical…

Computation and Language · Computer Science 2024-09-24 Jinqiang Wang , Huansheng Ning , Yi Peng , Qikai Wei , Daniel Tesfai , Wenwei Mao , Tao Zhu , Runhe Huang

Effective patient-provider communication is difficult to assess at scale. We examine whether large language models (LLMs) can track 20 social behaviors from clinical transcripts without fine-tuning. Across three model families and multiple…

Computation and Language · Computer Science 2026-05-14 Manas Satish Bedmutha , Feng Chen , Andrea Hartzler , Trevor Cohen , Nadir Weibel

The escalating global mental health crisis, marked by persistent treatment gaps, availability, and a shortage of qualified therapists, positions Large Language Models (LLMs) as a promising avenue for scalable support. While LLMs offer…

Large Language Models (LLMs) have demonstrated impressive capabilities in role-playing scenarios, particularly in simulating domain-specific experts using tailored prompts. This ability enables LLMs to adopt the persona of individuals with…

Artificial Intelligence · Computer Science 2025-01-14 Xinyao Ma , Rui Zhu , Zihao Wang , Jingwei Xiong , Qingyu Chen , Haixu Tang , L. Jean Camp , Lucila Ohno-Machado

In this study, we aimed to determine if fine-tuned large language models (LLMs) can generate accurate, personalized impressions for whole-body PET reports. Twelve language models were trained on a corpus of PET reports using the…

Recent advances in psychotherapy have focused on treatment personalization, such as by selecting treatment modules based on personalized networks. However, estimating personalized networks typically requires intensive longitudinal data,…

Artificial Intelligence · Computer Science 2025-12-08 Clarissa W. Ong , Hiba Arnaout , Kate Sheehan , Estella Fox , Eugen Owtscharow , Iryna Gurevych

Large language models (LLMs) show promise for supporting clinicians in diagnostic communication by generating explanations and guidance for patients. Yet their ability to produce outputs that are both understandable and empathetic remains…

Computation and Language · Computer Science 2025-11-04 Jianzhou Yao , Shunchang Liu , Guillaume Drui , Rikard Pettersson , Alessandro Blasimme , Sara Kijewski

IMPORTANCE The response effectiveness of different large language models (LLMs) and various individuals, including medical students, graduate students, and practicing physicians, in pediatric ophthalmology consultations, has not been…

Computation and Language · Computer Science 2023-11-09 Jason Holmes , Rui Peng , Yiwei Li , Jinyu Hu , Zhengliang Liu , Zihao Wu , Huan Zhao , Xi Jiang , Wei Liu , Hong Wei , Jie Zou , Tianming Liu , Yi Shao
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